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Optical diffraction-based silicon sensors for the detection of DNA sequences

Optical diffraction-based silicon sensors for the detection of DNA sequences
Optical diffraction-based silicon sensors for the detection of DNA sequences
This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays.
Weld, Andrew Mark
6cb1b99f-64b4-4f86-9fc7-b1283d45e699
Weld, Andrew Mark
6cb1b99f-64b4-4f86-9fc7-b1283d45e699

Weld, Andrew Mark (2007) Optical diffraction-based silicon sensors for the detection of DNA sequences. University of Southampton, Optoelectronic Research Centre, Doctoral Thesis, 249pp.

Record type: Thesis (Doctoral)

Abstract

This thesis describes the design, fabrication and characterisation of diffraction-based sensors on silicon (100) substrates for the detection of complementary DNA sequences using colloidal gold labels. In-depth analysis of variations of DNA sequence within the human genome and association with diseases is expected to lead to personalised medical treatment. There is a great need for DNA analysis technologies and for techniques to determine whether sequence variations occur on the same chromosomal strand with applications in disease screening and diagnosis. Novel two-dimensional diffraction structures are designed and fabricated. It is shown that two-dimensional diffraction approaches may potentially offer multiplexing of DNA detection assays.

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Published date: 29 June 2007
Organisations: University of Southampton

Identifiers

Local EPrints ID: 47762
URI: http://eprints.soton.ac.uk/id/eprint/47762
PURE UUID: a386888a-0cb0-4590-a8a5-1b77bfdaae61

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Date deposited: 15 Aug 2007
Last modified: 13 Mar 2019 20:59

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Contributors

Author: Andrew Mark Weld

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