Early life programming of skeletal health
Early life programming of skeletal health
Purpose of review: increasing bone mineral accrual during childhood might delay the onset of osteoporosis. We discuss the scientific evidence for early life approaches to optimising skeletal health.
Recent findings: there is an ever-growing body of evidence from observational studies suggesting associations between early life exposures, particularly during foetal development, and bone mineral density (BMD). The findings of such studies are often heterogeneous, and for some exposures, for example, maternal smoking and alcohol intake in pregnancy or age at conception, intervention studies are not feasible. The most frequently studied exposures in intervention studies are calcium or vitamin D supplementation in pregnancy, which overall suggest positive effects on offspring childhood BMD.
Summary: maternal calcium and/or vitamin D supplementation during pregnancy appear to have positive effects on offspring BMD during early childhood, but further long-term follow-up is required to demonstrate persistence of the effect into later life.
Bone mineral density, Calcium, Developmental programming, Epidemiology, Epigenetics, Osteoporosis, Vitamin D
433-446
Moon, Rebecca J
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Citeroni, Natasha L
fe42457c-fce7-469a-9c6d-538f12eadad6
Aihie, Riagbonse R
b4967d9c-15a7-4ef0-8d2e-dda090dbe17a
Harvey, Nicholas C
ce487fb4-d360-4aac-9d17-9466d6cba145
August 2023
Moon, Rebecca J
16ba3d3f-010f-4b11-a9c2-635979a27f4a
Citeroni, Natasha L
fe42457c-fce7-469a-9c6d-538f12eadad6
Aihie, Riagbonse R
b4967d9c-15a7-4ef0-8d2e-dda090dbe17a
Harvey, Nicholas C
ce487fb4-d360-4aac-9d17-9466d6cba145
Moon, Rebecca J, Citeroni, Natasha L, Aihie, Riagbonse R and Harvey, Nicholas C
(2023)
Early life programming of skeletal health.
Current Osteoporosis Reports, 21 (4), .
(doi:10.1007/s11914-023-00800-y).
Abstract
Purpose of review: increasing bone mineral accrual during childhood might delay the onset of osteoporosis. We discuss the scientific evidence for early life approaches to optimising skeletal health.
Recent findings: there is an ever-growing body of evidence from observational studies suggesting associations between early life exposures, particularly during foetal development, and bone mineral density (BMD). The findings of such studies are often heterogeneous, and for some exposures, for example, maternal smoking and alcohol intake in pregnancy or age at conception, intervention studies are not feasible. The most frequently studied exposures in intervention studies are calcium or vitamin D supplementation in pregnancy, which overall suggest positive effects on offspring childhood BMD.
Summary: maternal calcium and/or vitamin D supplementation during pregnancy appear to have positive effects on offspring BMD during early childhood, but further long-term follow-up is required to demonstrate persistence of the effect into later life.
Text
s11914-023-00800-y
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More information
Accepted/In Press date: 2 June 2023
Published date: August 2023
Additional Information:
© 2023. The Author(s).
Keywords:
Bone mineral density, Calcium, Developmental programming, Epidemiology, Epigenetics, Osteoporosis, Vitamin D
Identifiers
Local EPrints ID: 478528
URI: http://eprints.soton.ac.uk/id/eprint/478528
PURE UUID: cbd793b1-8cd0-4aa1-9117-3e83e567f42a
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Date deposited: 04 Jul 2023 17:47
Last modified: 17 Mar 2024 02:59
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Contributors
Author:
Rebecca J Moon
Author:
Natasha L Citeroni
Author:
Riagbonse R Aihie
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