Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?
Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?
The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.
High sensitivity troponin, critical care, myocardial infarction
392 - 398
Hinton, Jonathan William
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Augustine, Maclyn
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Gabara, Lavinia
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Mariathas, Mark
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Allan, Rick
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Borca, Florina
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Nicholas, Zoe
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Gillett, Neil
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Kwok, Chun Shing
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Cook, Paul
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Grocott, Michael P.W.
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Mamas, Mamas A.
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Curzen, Nicholas
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30 March 2023
Hinton, Jonathan William
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Augustine, Maclyn
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Gabara, Lavinia
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Mariathas, Mark
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Allan, Rick
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Borca, Florina
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Nicholas, Zoe
98403583-c418-45ad-836b-1831517dcc5f
Gillett, Neil
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Kwok, Chun Shing
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Cook, Paul
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Grocott, Michael P.W.
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Mamas, Mamas A.
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Curzen, Nicholas
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Hinton, Jonathan William, Augustine, Maclyn, Gabara, Lavinia, Mariathas, Mark, Allan, Rick, Borca, Florina, Nicholas, Zoe, Gillett, Neil, Kwok, Chun Shing, Cook, Paul, Grocott, Michael P.W., Mamas, Mamas A. and Curzen, Nicholas
(2023)
Is high sensitivity troponin, taken regardless of a clinical indication, associated with 1 year mortality in critical care patients?
Journal of the Intensive Care Society, 24 (4), .
(doi:10.1177/17511437231160078).
Abstract
The aim of this study was to assess whether high sensitivity troponin (hs-cTnI) is associated with 1 year mortality in critical care (CC). One year mortality data were obtained from NHS Digital for a consecutive cohort of patients admitted to general CC unit (GCCU) and neuroscience CC unit (NCCU) who had hs-cTnI tests performed throughout their CC admission, regardless of whether the test was clinically indicated. Cox proportional hazards were used to estimate the risk of 1-year mortality. A landmark analysis was undertaken to assess whether any relationship at 1 year was driven by mortality within the first 30 days. A total of 1033 consecutive patients were included. At 1 year 254 (24.6%) patients had died. The admission log(10)hs-cTnI concentration in the entire cohort (HR 1.35 (95% CI 1.05–1.75) p = 0.009 with a bootstrap of 1000 samples) was independently associated with 1 year mortality. On landmark analysis the association with 1 year mortality was driven by 30 day mortality. These results indicate that admission hs-cTnI concentration is independently associated with 1 year mortality in CC and this relationship may be driven by differences in mortality at 30 days.
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e-pub ahead of print date: 30 March 2023
Published date: 30 March 2023
Additional Information:
Funding Information:
The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: M. P. W. Grocott—unrestricted research grants from Pharmacosmos Ltd and Sphere Medical Ltd as well honoraria for speaking and/or travel expenses from: Astra Zeneca, Edwards Lifescience, Fresenius-Kabi, BOC Medical (Linde Group), Ely-Lilly Critical Care and Cortex GmBH. N. Curzen—unrestricted research grants from: Boston Scientific; Heartflow; Beckman Coulter. Speaker fees/consultancy from: Abbot Vascular; Heartflow; Boston Scientific; travel sponsorship—Edwards; Biosensors, Abbot, Lilly/D-S; St Jude Medical, Medtronic.
Publisher Copyright:
© The Intensive Care Society 2023.
Keywords:
High sensitivity troponin, critical care, myocardial infarction
Identifiers
Local EPrints ID: 478771
URI: http://eprints.soton.ac.uk/id/eprint/478771
ISSN: 1751-1437
PURE UUID: 743aa2d6-1432-48f5-b58c-9527f8fe4ebe
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Date deposited: 10 Jul 2023 16:34
Last modified: 18 Mar 2024 03:01
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Contributors
Author:
Jonathan William Hinton
Author:
Maclyn Augustine
Author:
Lavinia Gabara
Author:
Mark Mariathas
Author:
Rick Allan
Author:
Florina Borca
Author:
Zoe Nicholas
Author:
Neil Gillett
Author:
Chun Shing Kwok
Author:
Paul Cook
Author:
Mamas A. Mamas
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