The impact of fish oil and/or probiotics on serum fatty acids and the interaction with low-grade inflammation in pregnant women with overweight and obesity: secondary analysis of a randomised controlled trial
The impact of fish oil and/or probiotics on serum fatty acids and the interaction with low-grade inflammation in pregnant women with overweight and obesity: secondary analysis of a randomised controlled trial
N-3 long-chain PUFA (LC-PUFA) and probiotics are generally considered to induce health benefits. The objective was to investigate (1) the impact of fish oil and/or probiotics on serum fatty acids (sFA), (2) the interaction of sFA with low-grade inflammation and (3) the relation of sFA to the onset of gestational diabetes mellitus (GDM). Pregnant women with overweight/obesity were allocated into intervention groups with fish oil + placebo, probiotics + placebo, fish oil + probiotics or placebo + placebo in early pregnancy (fish oil: 1·9 g DHA and 0·22 g EPA, probiotics: Lacticaseibacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420, 10
10 CFU, each daily). Blood samples were collected in early (n 431) and late pregnancy (n 361) for analysis of fatty acids in serum phosphatidylcholine (PC), cholesteryl esters (CE), TAG and NEFA with GC and high-sensitivity C-reactive protein and GlycA by immunoassay and NMR spectroscopy, respectively. GDM was diagnosed according to 2 h 75 g oral glucose tolerance test. EPA in PC, CE and TAG and DHA in PC, CE, TAG and NEFA were higher in fish oil and fish oil + probiotics groups compared with placebo. EPA in serum NEFA was lower in women receiving probiotics compared with women not receiving. Low-grade inflammation was inversely associated with n-3 LC-PUFA, which were related to an increased risk of GDM. Fish oil and fish oil + probiotics consumption increase serum n-3 LC-PUFA in pregnant women with overweight/obesity. Although these fatty acids were inversely related to inflammatory markers, n-3 LC-PUFA were linked with an increased risk for GDM.
Fish oil, gestational diabetes mellitus, low-grade inflammation, probiotics, serum fatty acids
296-311
Houttu, Noora
e1ffb9db-471b-4236-a6d4-99874dcdb99f
Vahlberg, Tero
85c7dd6e-3e83-4cba-a5be-1ab38694f69b
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Laitinen, Kirsi
69920c2f-412e-49f8-894a-4b5500bf9e7a
29 August 2023
Houttu, Noora
e1ffb9db-471b-4236-a6d4-99874dcdb99f
Vahlberg, Tero
85c7dd6e-3e83-4cba-a5be-1ab38694f69b
Miles, Elizabeth A.
20332899-ecdb-4214-95bc-922dde36d416
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Laitinen, Kirsi
69920c2f-412e-49f8-894a-4b5500bf9e7a
Houttu, Noora, Vahlberg, Tero, Miles, Elizabeth A., Calder, Philip C. and Laitinen, Kirsi
(2023)
The impact of fish oil and/or probiotics on serum fatty acids and the interaction with low-grade inflammation in pregnant women with overweight and obesity: secondary analysis of a randomised controlled trial.
British Journal of Nutrition, 131 (2), .
(doi:10.1017/S0007114523001915).
Abstract
N-3 long-chain PUFA (LC-PUFA) and probiotics are generally considered to induce health benefits. The objective was to investigate (1) the impact of fish oil and/or probiotics on serum fatty acids (sFA), (2) the interaction of sFA with low-grade inflammation and (3) the relation of sFA to the onset of gestational diabetes mellitus (GDM). Pregnant women with overweight/obesity were allocated into intervention groups with fish oil + placebo, probiotics + placebo, fish oil + probiotics or placebo + placebo in early pregnancy (fish oil: 1·9 g DHA and 0·22 g EPA, probiotics: Lacticaseibacillus rhamnosus HN001 and Bifidobacterium animalis ssp. lactis 420, 10
10 CFU, each daily). Blood samples were collected in early (n 431) and late pregnancy (n 361) for analysis of fatty acids in serum phosphatidylcholine (PC), cholesteryl esters (CE), TAG and NEFA with GC and high-sensitivity C-reactive protein and GlycA by immunoassay and NMR spectroscopy, respectively. GDM was diagnosed according to 2 h 75 g oral glucose tolerance test. EPA in PC, CE and TAG and DHA in PC, CE, TAG and NEFA were higher in fish oil and fish oil + probiotics groups compared with placebo. EPA in serum NEFA was lower in women receiving probiotics compared with women not receiving. Low-grade inflammation was inversely associated with n-3 LC-PUFA, which were related to an increased risk of GDM. Fish oil and fish oil + probiotics consumption increase serum n-3 LC-PUFA in pregnant women with overweight/obesity. Although these fatty acids were inversely related to inflammatory markers, n-3 LC-PUFA were linked with an increased risk for GDM.
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the-impact-of-fish-oil-andor-probiotics-on-serum-fatty-acids-and-the-interaction-with-low-grade-inflammation-in-pregnant-women-with-overweight-and-obesity-secondary-analysis-of-a-randomised-controlled
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Accepted/In Press date: 21 August 2023
e-pub ahead of print date: 29 August 2023
Published date: 29 August 2023
Additional Information:
Publisher Copyright:
© 2023 The Author(s). Published by Cambridge University Press on behalf of The Nutrition Society.
Keywords:
Fish oil, gestational diabetes mellitus, low-grade inflammation, probiotics, serum fatty acids
Identifiers
Local EPrints ID: 481401
URI: http://eprints.soton.ac.uk/id/eprint/481401
ISSN: 0007-1145
PURE UUID: b0e588b0-dbc9-4de7-97d7-7f2452d9b617
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Date deposited: 25 Aug 2023 16:35
Last modified: 18 Mar 2024 02:41
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Author:
Noora Houttu
Author:
Tero Vahlberg
Author:
Kirsi Laitinen
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