T lymphocytes and their potential role in dementia with Lewy bodies
T lymphocytes and their potential role in dementia with Lewy bodies
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia. People with DLB have an inferior prognosis compared to Alzheimer’s disease (AD), but the diseases overlap in their neuropathology and clinical syndrome. It is imperative that we enhance our understanding of the aetiology and pathogenesis of DLB. The impact of peripheral inflammation on the brain in dementia has been increasingly explored in recent years, with T lymphocyte recruitment into brain parenchyma identified in AD and Parkinson’s disease. There is now a growing range of literature emerging on the potential role of innate and adaptive immune cells in DLB, including T lymphocytes. In this review, we examine the profile of T lymphocytes in DLB, focusing on studies of post-mortem brain tissue, cerebrospinal fluid, and the blood compartment. We present an integrated viewpoint on the results of these studies by proposing how changes to the T lymphocyte profile in the brain and periphery may relate to each other. Improving our understanding of T lymphocytes in DLB has the potential to guide the development of disease-modifying treatments.
T cells, adaptive immunity, dementia with Lewy bodies, inflammation, lymphocytes
Amin, Jay
692a8880-70ff-4b64-a7e9-7d0d53449a30
Gee, Claire
c5597f3b-2b82-4d59-999b-71cd292b4b08
Stowell, Kiran
29dc358e-4477-4913-af23-f14e9d7f51d5
Coulthard, Daisy
af30c0e5-7adc-4147-a2f6-14b86af6924a
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
15 September 2023
Amin, Jay
692a8880-70ff-4b64-a7e9-7d0d53449a30
Gee, Claire
c5597f3b-2b82-4d59-999b-71cd292b4b08
Stowell, Kiran
29dc358e-4477-4913-af23-f14e9d7f51d5
Coulthard, Daisy
af30c0e5-7adc-4147-a2f6-14b86af6924a
Boche, Delphine
bdcca10e-6302-4dd0-919f-67218f7e0d61
Amin, Jay, Gee, Claire, Stowell, Kiran, Coulthard, Daisy and Boche, Delphine
(2023)
T lymphocytes and their potential role in dementia with Lewy bodies.
Cells, 12 (18), [2283].
(doi:10.3390/cells12182283).
Abstract
Dementia with Lewy bodies (DLB) is the second most common neurodegenerative cause of dementia. People with DLB have an inferior prognosis compared to Alzheimer’s disease (AD), but the diseases overlap in their neuropathology and clinical syndrome. It is imperative that we enhance our understanding of the aetiology and pathogenesis of DLB. The impact of peripheral inflammation on the brain in dementia has been increasingly explored in recent years, with T lymphocyte recruitment into brain parenchyma identified in AD and Parkinson’s disease. There is now a growing range of literature emerging on the potential role of innate and adaptive immune cells in DLB, including T lymphocytes. In this review, we examine the profile of T lymphocytes in DLB, focusing on studies of post-mortem brain tissue, cerebrospinal fluid, and the blood compartment. We present an integrated viewpoint on the results of these studies by proposing how changes to the T lymphocyte profile in the brain and periphery may relate to each other. Improving our understanding of T lymphocytes in DLB has the potential to guide the development of disease-modifying treatments.
Text
T cells DLB review submitted revised clean
- Accepted Manuscript
Text
cells-12-02283
- Version of Record
More information
Accepted/In Press date: 12 September 2023
e-pub ahead of print date: 15 September 2023
Published date: 15 September 2023
Additional Information:
Funding Information:
This review was supported by funding from the University of Southampton.
Publisher Copyright:
© 2023 by the authors.
Keywords:
T cells, adaptive immunity, dementia with Lewy bodies, inflammation, lymphocytes
Identifiers
Local EPrints ID: 482038
URI: http://eprints.soton.ac.uk/id/eprint/482038
ISSN: 2073-4409
PURE UUID: cda8405e-7977-41fb-83c3-b52534754da9
Catalogue record
Date deposited: 18 Sep 2023 16:34
Last modified: 30 Nov 2024 02:50
Export record
Altmetrics
Contributors
Author:
Claire Gee
Author:
Kiran Stowell
Author:
Daisy Coulthard
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
