Surfactin conjugated silver nanoparticles as an antibacterial and antibiofilm agent against pseudomonas aeruginosa
Surfactin conjugated silver nanoparticles as an antibacterial and antibiofilm agent against pseudomonas aeruginosa
The emergence of antimicrobial resistance is an alarming global health concern and has stimulated the development of novel functional nanomaterials to combat multi-drug-resistant (MDR) bacteria. In this work, we demonstrate for the first time the synthesis and application of surfactin-coated silver nanoparticles as an efficient antibacterial and antibiofilm agent against the drug-resistant bacteria Pseudomonas aeruginosa for safe dermal applications. Our in vivo studies showed no significant superficial dermal irritation, edema, and erythema, while microscopic analysis revealed that surfactin-coated silver nanoparticles caused no pathological alterations at the applied concentrations. These results support the potential use of surfactin-coated silver nanoparticles against drug-resistant bacterial biofilm infections and in skin wound dressing applications.
antimicrobial resistance, bacteria, cytotoxicity, dermal irritation, silver nanoparticles, surfactin
43321–43331
Rahman, Lutfur
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Yasra Sarwar, Yasra
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Khaliq, Shazia
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Inayatullah,
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Abbas, Wasim
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Mobeen, Ameena
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Ullah, Ata
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Hussain, Syed Zajif
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Khan, Waheed
615a9467-b265-49da-9f93-bfac450f1fd1
Kyriazi, Maria-Eleni
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Hussain, Irshad
f418e899-f0a5-4d57-af09-b16b5c641af3
Kanaras, Antonios
667ecfdc-7647-4bd8-be03-a47bf32504c7
Rehman, Asma
9852259e-a5ba-42f4-b112-e58834b606b8
5 September 2023
Rahman, Lutfur
4b7377d3-0944-4c40-b6e7-32eefc78664f
Yasra Sarwar, Yasra
5355dbf8-f70e-48dd-84b1-df64fd7a13d5
Khaliq, Shazia
a37a0d4a-2600-49a3-95d7-f9e39d890eff
Inayatullah,
99c24958-07e4-4db8-9242-7e9a3c46d7e1
Abbas, Wasim
2861dec0-a45e-4679-b115-ef0c1cd288be
Mobeen, Ameena
7f8e7db8-436e-4301-b9e6-65d9560e2c38
Ullah, Ata
9c3647c8-a2bd-4aa7-8f4e-b1594305f606
Hussain, Syed Zajif
4201eac6-4376-44b0-9634-191994650911
Khan, Waheed
615a9467-b265-49da-9f93-bfac450f1fd1
Kyriazi, Maria-Eleni
27777bbf-b79e-4908-8fb4-cba50b689bca
Hussain, Irshad
f418e899-f0a5-4d57-af09-b16b5c641af3
Kanaras, Antonios
667ecfdc-7647-4bd8-be03-a47bf32504c7
Rehman, Asma
9852259e-a5ba-42f4-b112-e58834b606b8
Rahman, Lutfur, Yasra Sarwar, Yasra, Khaliq, Shazia, Inayatullah, , Abbas, Wasim, Mobeen, Ameena, Ullah, Ata, Hussain, Syed Zajif, Khan, Waheed, Kyriazi, Maria-Eleni, Hussain, Irshad, Kanaras, Antonios and Rehman, Asma
(2023)
Surfactin conjugated silver nanoparticles as an antibacterial and antibiofilm agent against pseudomonas aeruginosa.
ACS Applied Materials and Interfaces, 15 (37), .
(doi:10.1021/acsami.3c07071).
Abstract
The emergence of antimicrobial resistance is an alarming global health concern and has stimulated the development of novel functional nanomaterials to combat multi-drug-resistant (MDR) bacteria. In this work, we demonstrate for the first time the synthesis and application of surfactin-coated silver nanoparticles as an efficient antibacterial and antibiofilm agent against the drug-resistant bacteria Pseudomonas aeruginosa for safe dermal applications. Our in vivo studies showed no significant superficial dermal irritation, edema, and erythema, while microscopic analysis revealed that surfactin-coated silver nanoparticles caused no pathological alterations at the applied concentrations. These results support the potential use of surfactin-coated silver nanoparticles against drug-resistant bacterial biofilm infections and in skin wound dressing applications.
Text
Rehman_Revised_Surfactin_Manuscript
- Accepted Manuscript
More information
Accepted/In Press date: 18 August 2023
e-pub ahead of print date: 5 September 2023
Published date: 5 September 2023
Additional Information:
Funding Information:
L.R. and A.R. gratefully acknowledge the financial support from the International Foundation for Science (IFS) Sweden (Grant No. 12-W-6706-1).
Publisher Copyright:
© 2023 American Chemical Society.
Keywords:
antimicrobial resistance, bacteria, cytotoxicity, dermal irritation, silver nanoparticles, surfactin
Identifiers
Local EPrints ID: 482212
URI: http://eprints.soton.ac.uk/id/eprint/482212
ISSN: 1944-8244
PURE UUID: cedaa9c0-b50d-40fc-961b-80fba7d1c90e
Catalogue record
Date deposited: 21 Sep 2023 16:43
Last modified: 12 Nov 2024 05:02
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Contributors
Author:
Lutfur Rahman
Author:
Yasra Yasra Sarwar
Author:
Shazia Khaliq
Author:
Inayatullah
Author:
Wasim Abbas
Author:
Ameena Mobeen
Author:
Ata Ullah
Author:
Syed Zajif Hussain
Author:
Waheed Khan
Author:
Maria-Eleni Kyriazi
Author:
Irshad Hussain
Author:
Asma Rehman
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