Artificial intelligence for neurodegenerative experimental models

Accepted/In Press date: 14 August 2023

e-pub ahead of print date: 28 September 2023

Published date: December 2023

Additional Information: Funding Information: This manuscript was facilitated by the Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment (ISTAART), through the AI for Precision Dementia Medicine Professional Interest Area (PIA). The views and opinions expressed by authors in this publication represent those of the authors and do not necessarily reflect those of the PIA membership, ISTAART, or the Alzheimer's Association. With thanks to the Deep Dementia Phenotyping (DEMON) Network State of the Science symposium participants (in alphabetical order): Peter Bagshaw, Robin Borchert, Magda Bucholc, James Duce, Charlotte James, David Llewellyn, Donald Lyall, Sarah Marzi, Danielle Newby, Neil Oxtoby, Janice Ranson, Tim Rittman, Nathan Skene, Eugene Tang, Michele Veldsman, Laura Winchester, Zhi Yao. This paper was the product of a DEMON Network State of the Science symposium entitled “Harnessing Data Science and AI in Dementia Research” funded by Alzheimer's Research UK. JMR and DJL are supported by Alzheimer's Research UK and the Alan Turing Institute/Engineering and Physical Sciences Research Council (EP/N510129/1). DJL also receives funding from the Medical Research Council (MR/X005674/1), National Institute for Health Research (NIHR) Applied Research Collaboration South West Peninsula, National Health and Medical Research Council (NHMRC), and National Institute on Aging/National Institutes of Health (RF1AG055654). SJM and AN are funded by the Edmond and Lily Safra Early Career Fellowship Program and the UK Dementia Research Institute, which receives its funding from UK DRI Ltd, funded by the UK Medical Research Council, Alzheimer's Society, and Alzheimer's Research UK. MB is supported by Alzheimer's Research UK, Economic and Social Research Council (ES/W010240/1), EU (SEUPB) INTERREG (ERDF/SEUPB), and HSC R&D (COM/5750/23). PAL acknowledges generous support from the Michael J. Fox Foundation and Parkinson's UK. CJ and LMW are supported by Alzheimer's Research UK. Publisher Copyright: © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Keywords: animal models artificial intelligence comparative biology dementia experimental models FAIR in silico in vitro in vivo iPSC machine learning neurodegeneration preclinical reproducibility translation, animal models, comparative biology, FAIR, reproducibility, iPSC, neurodegeneration, in silico, machine learning, artificial intelligence, experimental models, preclinical, in vitro, translation, dementia, in vivo

Local EPrints ID: 482711

URI: http://eprints.soton.ac.uk/id/eprint/482711

DOI: doi:10.1002/alz.13479

ISSN: 1552-5260

PURE UUID: 6e136ea0-db00-4d51-9a54-77578b2f8446

ORCID for Sandrine Willaime-Morawek: orcid.org/0000-0002-1121-6419

Date deposited: 11 Oct 2023 16:56

Last modified: 13 Apr 2024 01:42