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The prevalence of foot pain and association with baseline characteristics in people participating in education and supervised exercise for knee or hip osteoarthritis: a cross-sectional study of 26,003 participants from the GLA:D® registry

The prevalence of foot pain and association with baseline characteristics in people participating in education and supervised exercise for knee or hip osteoarthritis: a cross-sectional study of 26,003 participants from the GLA:D® registry
The prevalence of foot pain and association with baseline characteristics in people participating in education and supervised exercise for knee or hip osteoarthritis: a cross-sectional study of 26,003 participants from the GLA:D® registry
Background: osteoarthritis (OA) affecting the knee or hip is highly prevalent in the general population and has associated high disease burden. Early identification of modifiable risk factors that prevent, limit, or resolve disease symptoms is critical. Foot pain may represent a potentially modifiable factor however little is known about the prevalence of foot pain in people with knee or hip OA nor whether foot pain is associated with clinical characteristics. The main aim of this study was therefore to determine the prevalence of foot pain in people with knee or hip OA attending an education and supervised exercise-based intervention in Denmark (GLA:D®) and determine if baseline demographic or clinical characteristics are associated with foot pain.

Methods: analysis was conducted on baseline data of 26,003 people with symptomatic knee or hip OA completing a pain mannequin as part of the Good Life with osteoArthritis in Denmark (GLA:D®) primary care programme. Odds Ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the strength of association between baseline clinical characteristics (including pain severity in worst knee/hip joint, number of painful knee/hip joints, pain medication use and physical activity level) and the presence of baseline foot pain.

Results: twelve percent of participants (n=3,049) reported foot pain. In those people with index knee OA (n= 19,391), knee pain severity (OR 1.01 CI 1.00, 1.01), number of painful knee/hip joints (OR 1.67 CI 1.58, 1.79), and use of pain medication (OR 1.23 CI 1.12, 1.36) were statistically associated with foot pain. Excluding use of pain medication, similar associations were seen in those with index hip OA.

Conclusion: twelve percent of people with knee or hip OA participating in GLA:D® had foot pain. Those with worse knee/hip pain, and greater number of painful joints were more likely to report foot pain. This study is the first to demonstrate a significant relationship between clinical characteristics and foot pain in people with knee or hip OA participating in education and supervised exercise. Future investigation should consider the role that foot pain may play on knee and hip related outcomes following therapeutic intervention.
1757-1146
Gates, Lucy S.
bc67b8b8-110b-4358-8e1b-6f1d345bd503
Cherry, Lindsey
95256156-ce8c-4e7c-b04d-b6e459232441
Grønne, Dorte T.
47df5551-557c-46f5-9927-3c0ffc2eecf1
Roos, Ewa M.
b4e1df9a-f940-4a3d-aabd-81734a3c308c
Skou, Søren T.
4d6270f8-d980-4b80-a5ed-a2b7f06ca3d9
Gates, Lucy S.
bc67b8b8-110b-4358-8e1b-6f1d345bd503
Cherry, Lindsey
95256156-ce8c-4e7c-b04d-b6e459232441
Grønne, Dorte T.
47df5551-557c-46f5-9927-3c0ffc2eecf1
Roos, Ewa M.
b4e1df9a-f940-4a3d-aabd-81734a3c308c
Skou, Søren T.
4d6270f8-d980-4b80-a5ed-a2b7f06ca3d9

Gates, Lucy S., Cherry, Lindsey, Grønne, Dorte T., Roos, Ewa M. and Skou, Søren T. (2023) The prevalence of foot pain and association with baseline characteristics in people participating in education and supervised exercise for knee or hip osteoarthritis: a cross-sectional study of 26,003 participants from the GLA:D® registry. Journal of Foot and Ankle Research. (In Press)

Record type: Article

Abstract

Background: osteoarthritis (OA) affecting the knee or hip is highly prevalent in the general population and has associated high disease burden. Early identification of modifiable risk factors that prevent, limit, or resolve disease symptoms is critical. Foot pain may represent a potentially modifiable factor however little is known about the prevalence of foot pain in people with knee or hip OA nor whether foot pain is associated with clinical characteristics. The main aim of this study was therefore to determine the prevalence of foot pain in people with knee or hip OA attending an education and supervised exercise-based intervention in Denmark (GLA:D®) and determine if baseline demographic or clinical characteristics are associated with foot pain.

Methods: analysis was conducted on baseline data of 26,003 people with symptomatic knee or hip OA completing a pain mannequin as part of the Good Life with osteoArthritis in Denmark (GLA:D®) primary care programme. Odds Ratios (OR) and 95% confidence intervals (CI) were calculated to estimate the strength of association between baseline clinical characteristics (including pain severity in worst knee/hip joint, number of painful knee/hip joints, pain medication use and physical activity level) and the presence of baseline foot pain.

Results: twelve percent of participants (n=3,049) reported foot pain. In those people with index knee OA (n= 19,391), knee pain severity (OR 1.01 CI 1.00, 1.01), number of painful knee/hip joints (OR 1.67 CI 1.58, 1.79), and use of pain medication (OR 1.23 CI 1.12, 1.36) were statistically associated with foot pain. Excluding use of pain medication, similar associations were seen in those with index hip OA.

Conclusion: twelve percent of people with knee or hip OA participating in GLA:D® had foot pain. Those with worse knee/hip pain, and greater number of painful joints were more likely to report foot pain. This study is the first to demonstrate a significant relationship between clinical characteristics and foot pain in people with knee or hip OA participating in education and supervised exercise. Future investigation should consider the role that foot pain may play on knee and hip related outcomes following therapeutic intervention.

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Accepted/In Press date: 16 October 2023

Identifiers

Local EPrints ID: 483655
URI: http://eprints.soton.ac.uk/id/eprint/483655
ISSN: 1757-1146
PURE UUID: 03bbc314-ce5c-44b3-89bc-897f055f68d8
ORCID for Lucy S. Gates: ORCID iD orcid.org/0000-0002-8627-3418
ORCID for Lindsey Cherry: ORCID iD orcid.org/0000-0002-3165-1004

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Date deposited: 02 Nov 2023 18:25
Last modified: 03 Nov 2023 02:45

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Contributors

Author: Lucy S. Gates ORCID iD
Author: Lindsey Cherry ORCID iD
Author: Dorte T. Grønne
Author: Ewa M. Roos
Author: Søren T. Skou

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