Microbiotoxicity: antibiotic usage and its unintended harm to the microbiome
Microbiotoxicity: antibiotic usage and its unintended harm to the microbiome
Purpose of review: antibiotic use is associated with development of antimicrobial resistance and dysregulation of the microbiome (the overall host microbial community). These changes have in turn been associated with downstream adverse health outcomes. This review analyses recent important publications in a rapidly evolving field, contextualizing the available evidence to assist clinicians weighing the potential risks of antibiotics on a patient's microbiome.
Recent finding: although the majority of microbiome research is observational, we highlight recent interventional studies probing the associations between antibiotic use, microbiome disruption, and ill-health. These studies include germ-free mouse models, antibiotic challenge in healthy human volunteers, and a phase III study of the world's first approved microbiome-based medicine.
Summary: the growing body of relevant clinical and experimental evidence for antibiotic-mediated microbiome perturbation is concerning, although further causal evidence is required. Within the limits of this evidence, we propose the novel term ‘microbiotoxicity’ to describe the unintended harms of antibiotics on a patient's microbiome. We suggest a framework for prescribers to weigh microbiotoxic effects against the intended benefits of antibiotic use
antimicrobial resistance, antimicrobial stewardship, dysbiosis, microbiome
371-378
Theodosiou, Anastasia A.
d0f2d7b5-6664-4b86-b738-25815681829b
Jones, Christine E .
48229079-8b58-4dcb-8374-d9481fe7b426
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Bogaert, Debby
ac4e1a3f-bbdd-4817-9647-bffe41ee3b2e
1 October 2023
Theodosiou, Anastasia A.
d0f2d7b5-6664-4b86-b738-25815681829b
Jones, Christine E .
48229079-8b58-4dcb-8374-d9481fe7b426
Read, Robert C.
b5caca7b-0063-438a-b703-7ecbb6fc2b51
Bogaert, Debby
ac4e1a3f-bbdd-4817-9647-bffe41ee3b2e
Theodosiou, Anastasia A., Jones, Christine E ., Read, Robert C. and Bogaert, Debby
(2023)
Microbiotoxicity: antibiotic usage and its unintended harm to the microbiome.
Current Opinion in Infectious Diseases, 36 (5), .
(doi:10.1097/QCO.0000000000000945).
Abstract
Purpose of review: antibiotic use is associated with development of antimicrobial resistance and dysregulation of the microbiome (the overall host microbial community). These changes have in turn been associated with downstream adverse health outcomes. This review analyses recent important publications in a rapidly evolving field, contextualizing the available evidence to assist clinicians weighing the potential risks of antibiotics on a patient's microbiome.
Recent finding: although the majority of microbiome research is observational, we highlight recent interventional studies probing the associations between antibiotic use, microbiome disruption, and ill-health. These studies include germ-free mouse models, antibiotic challenge in healthy human volunteers, and a phase III study of the world's first approved microbiome-based medicine.
Summary: the growing body of relevant clinical and experimental evidence for antibiotic-mediated microbiome perturbation is concerning, although further causal evidence is required. Within the limits of this evidence, we propose the novel term ‘microbiotoxicity’ to describe the unintended harms of antibiotics on a patient's microbiome. We suggest a framework for prescribers to weigh microbiotoxic effects against the intended benefits of antibiotic use
Text
microbiotoxicity__antibiotic_usage_and_its.12
- Version of Record
More information
Accepted/In Press date: 5 July 2023
e-pub ahead of print date: 25 July 2023
Published date: 1 October 2023
Additional Information:
Funding Information:
AT is funded by a Medical Research Council Clinical Research Training Fellowship (MR/V002015/1).D.B. is supported by a CSO Senior Scottish Clinical Fellowship (SCAF/16/03).
Keywords:
antimicrobial resistance, antimicrobial stewardship, dysbiosis, microbiome
Identifiers
Local EPrints ID: 484346
URI: http://eprints.soton.ac.uk/id/eprint/484346
ISSN: 0951-7375
PURE UUID: 2a4efe85-7044-4f76-a94a-f2f88a810494
Catalogue record
Date deposited: 15 Nov 2023 18:16
Last modified: 18 Mar 2024 03:21
Export record
Altmetrics
Contributors
Author:
Anastasia A. Theodosiou
Author:
Debby Bogaert
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics