Association of foot symptoms with decreased time to all-cause mortality: the Johnston County Osteoarthritis Project
Association of foot symptoms with decreased time to all-cause mortality: the Johnston County Osteoarthritis Project
Objective: adults with foot symptoms (ie, pain, aching, or stiffness) may be at increased risk of reduced time to all-cause mortality. The purpose of this study was to evaluate whether foot symptoms are independently associated with all-cause mortality in older adults.
Methods: we analyzed longitudinal data from 2613 participants from the Johnston County Osteoarthritis Project, a longitudinal population-based cohort of adults 45 years of age and older. Participants completed questionnaires at baseline to determine presence of foot symptoms and covariable status. Baseline walking speed was measured via an 8-foot walk test. To examine the association of foot symptoms with time to mortality, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression models, adjusted for potential confounders.
Results: we observed 813 deaths over 4 to 14.5 years of follow-up. At baseline, 37% of participants had foot symptoms, mean age was 63 years, mean body mass index was approximately 31 kg/m 2, 65% were women, and 33% were Black. Moderate to severe foot symptoms were associated with reduced time to mortality after adjustment for demographics, comorbidities, physical activity, and knee and hip symptoms (HR = 1.30, 95% CI 1.09–1.54). Importantly, this association was not modified by walking speed or diabetes.
Conclusion: individuals with foot symptoms had an increased hazard of all-cause mortality compared with those with no foot symptoms. These effects were independent of key confounders and were not moderated by walking speed. Effective interventions to identify and manage at least moderate foot symptoms may reduce the risk of decreased time to mortality.
Harmon, Skylar
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Alvarez, Carolina
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Hannan, Marian T.
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Callahan, Leigh F.
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Gates, Lucy S.
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Bowen, Catherine J.
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Menz, Hylton B.
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Nelson, Amanda E.
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Golightly, Yvonne M.
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3 November 2023
Harmon, Skylar
af116460-2ded-4722-b638-8a7fdf0d897b
Alvarez, Carolina
c8489acb-6cfe-4234-ae22-7f393368f00e
Hannan, Marian T.
33dedd86-72df-4e74-99a2-17cc044bd883
Callahan, Leigh F.
9a6582f6-a249-41df-9d45-f6739337c42f
Gates, Lucy S.
0cbba3d2-be6b-431a-a4bb-833da8322f16
Bowen, Catherine J.
fd85c3c5-96d9-49b8-86c6-caa94e1a222b
Menz, Hylton B.
d84b2aa7-9f46-45fd-98b2-f494ca4c5c83
Nelson, Amanda E.
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Golightly, Yvonne M.
a6f5eee3-9601-4e99-9210-c535bf01d72c
Harmon, Skylar, Alvarez, Carolina, Hannan, Marian T., Callahan, Leigh F., Gates, Lucy S., Bowen, Catherine J., Menz, Hylton B., Nelson, Amanda E. and Golightly, Yvonne M.
(2023)
Association of foot symptoms with decreased time to all-cause mortality: the Johnston County Osteoarthritis Project.
Arthritis Care and Research.
(doi:10.1002/acr.25186).
Abstract
Objective: adults with foot symptoms (ie, pain, aching, or stiffness) may be at increased risk of reduced time to all-cause mortality. The purpose of this study was to evaluate whether foot symptoms are independently associated with all-cause mortality in older adults.
Methods: we analyzed longitudinal data from 2613 participants from the Johnston County Osteoarthritis Project, a longitudinal population-based cohort of adults 45 years of age and older. Participants completed questionnaires at baseline to determine presence of foot symptoms and covariable status. Baseline walking speed was measured via an 8-foot walk test. To examine the association of foot symptoms with time to mortality, hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox regression models, adjusted for potential confounders.
Results: we observed 813 deaths over 4 to 14.5 years of follow-up. At baseline, 37% of participants had foot symptoms, mean age was 63 years, mean body mass index was approximately 31 kg/m 2, 65% were women, and 33% were Black. Moderate to severe foot symptoms were associated with reduced time to mortality after adjustment for demographics, comorbidities, physical activity, and knee and hip symptoms (HR = 1.30, 95% CI 1.09–1.54). Importantly, this association was not modified by walking speed or diabetes.
Conclusion: individuals with foot symptoms had an increased hazard of all-cause mortality compared with those with no foot symptoms. These effects were independent of key confounders and were not moderated by walking speed. Effective interventions to identify and manage at least moderate foot symptoms may reduce the risk of decreased time to mortality.
Text
363_Foot Symptoms are Associated with Decreased Time to All-Cause Mortality the Johnston County Osteoarthritis Project
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Arthritis Care Research - 2023 - Harmon - Association of Foot Symptoms With Decreased Time to All‐Cause Mortality The
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More information
Accepted/In Press date: 27 June 2023
e-pub ahead of print date: 29 June 2023
Published date: 3 November 2023
Additional Information:
Funding Information:
Supported by the CDC/Association of Schools of Public Health (grants S‐043, S‐1734, S‐3486, and U01‐DP‐003206), the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants P60‐AR‐30701, P60‐AR‐049465, P60‐AR‐064166, P30‐AR‐072580, and R01‐AR‐065937), the 2022 Medical Students in Aging Research program at University of North Carolina at Chapel Hill through the NIH/National Institute of Aging (grant 5T35‐AG‐038047).
Publisher Copyright:
© 2023 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology.
Identifiers
Local EPrints ID: 484642
URI: http://eprints.soton.ac.uk/id/eprint/484642
ISSN: 2151-464X
PURE UUID: a24421dc-70b1-4e46-b012-7f89209ee5af
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Date deposited: 17 Nov 2023 18:20
Last modified: 12 Apr 2024 01:37
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Contributors
Author:
Skylar Harmon
Author:
Carolina Alvarez
Author:
Marian T. Hannan
Author:
Leigh F. Callahan
Author:
Lucy S. Gates
Author:
Hylton B. Menz
Author:
Amanda E. Nelson
Author:
Yvonne M. Golightly
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