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The impact of methylphenidate on pubertal maturation and bone age in ADHD children and adolescents: results from the ADHD drugs use chronic effects (ADDUCE) project

The impact of methylphenidate on pubertal maturation and bone age in ADHD children and adolescents: results from the ADHD drugs use chronic effects (ADDUCE) project
The impact of methylphenidate on pubertal maturation and bone age in ADHD children and adolescents: results from the ADHD drugs use chronic effects (ADDUCE) project

Objective: the short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.

Method: participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.

Results: the medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.

Conclusion: our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

ADHD, bone age, growth, methylphenidate, pubertal maturation
1087-0547
722-739
Carucci, Sara
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Zuddas, Alessandro
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Lampis, Angelico
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Man, Kenneth K.C.
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Balia, Carla
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Buitelaar, Jan
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Danckaerts, Marina
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Dittmann, Ralf W.
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Donno, Federica
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Falissard, Bruno
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Gagliano, Antonella
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Garas, Peter
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Häge, Alexander
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Hollis, Chris
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Inglis, Sarah K.
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Konrad, Kerstin
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Kovshoff, Hanna
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Liddle, Elizabeth
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McCarthy, Suzanne
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Neubert, Antje
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Nagy, Peter
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Rosenthal, Eric
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Sonuga-Barke, Edmund J.S.
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Wong, Ian C.K.
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Banaschewski, Tobias
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Coghill, David
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The ADDUCE consortium
Carucci, Sara
7eb10d48-a95d-40cc-8331-bf1bc4139b8f
Zuddas, Alessandro
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Lampis, Angelico
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Man, Kenneth K.C.
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Balia, Carla
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Buitelaar, Jan
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Danckaerts, Marina
cf604909-5567-4a95-a5ed-dc7b35657e38
Dittmann, Ralf W.
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Donno, Federica
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Falissard, Bruno
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Gagliano, Antonella
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Garas, Peter
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Häge, Alexander
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Hollis, Chris
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Inglis, Sarah K.
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Konrad, Kerstin
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Kovshoff, Hanna
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Liddle, Elizabeth
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McCarthy, Suzanne
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Neubert, Antje
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Nagy, Peter
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Rosenthal, Eric
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Sonuga-Barke, Edmund J.S.
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Wong, Ian C.K.
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Banaschewski, Tobias
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Coghill, David
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Carucci, Sara, Zuddas, Alessandro and Lampis, Angelico , The ADDUCE consortium (2024) The impact of methylphenidate on pubertal maturation and bone age in ADHD children and adolescents: results from the ADHD drugs use chronic effects (ADDUCE) project. Journal of Attention Disorders, 28 (5), 722-739. (doi:10.1177/10870547241226726).

Record type: Article

Abstract

Objective: the short-term safety of methylphenidate (MPH) has been widely demonstrated; however the long-term safety is less clear. The aim of this study was to investigate the safety of MPH in relation to pubertal maturation and to explore the monitoring of bone age.

Method: participants from ADDUCE, a two-year observational longitudinal study with three parallel cohorts (MPH group, no-MPH group, and a non-ADHD control group), were compared with respect to Tanner staging. An Italian subsample of medicated-ADHD was further assessed by the monitoring of bone age.

Results: the medicated and unmedicated ADHD groups did not differ in Tanner stages indicating no higher risk of sexual maturational delay in the MPH-treated patients. The medicated subsample monitored for bone age showed a slight acceleration of the bone maturation after 24 months, however their predicted adult height remained stable.

Conclusion: our results do not suggest safety concerns on long-term treatment with MPH in relation to pubertal maturation and growth.

Text
ADDUCE pubertal maturation and bone age 15 oct 23 revised tracked changes[1] - Accepted Manuscript
Available under License University of Southampton Accepted Manuscript Licence.
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e-pub ahead of print date: 17 February 2024
Published date: March 2024
Additional Information: Funding Information: The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The project received funding from the European Union’s Seventh Framework Program for research, technological development and demonstration under grant agreement no. 260576. The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. However, the team worked with the European Medicines Agency to ensure that the objectives of ADDUCE program are addressing the public health concerns raised by the CHMP.
Keywords: ADHD, bone age, growth, methylphenidate, pubertal maturation

Identifiers

Local EPrints ID: 487854
URI: http://eprints.soton.ac.uk/id/eprint/487854
DOI: doi:10.1177/10870547241226726
ISSN: 1087-0547
PURE UUID: a09650c3-0ef3-4d10-9202-f9cca8c5b1b6
ORCID for Hanna Kovshoff: ORCID iD orcid.org/0000-0001-6041-0376

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Date deposited: 07 Mar 2024 17:30
Last modified: 27 Apr 2024 01:40

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Contributors

Author: Sara Carucci
Author: Alessandro Zuddas
Author: Angelico Lampis
Author: Kenneth K.C. Man
Author: Carla Balia
Author: Jan Buitelaar
Author: Marina Danckaerts
Author: Ralf W. Dittmann
Author: Federica Donno
Author: Bruno Falissard
Author: Antonella Gagliano
Author: Peter Garas
Author: Alexander Häge
Author: Chris Hollis
Author: Sarah K. Inglis
Author: Kerstin Konrad
Author: Hanna Kovshoff ORCID iD
Author: Elizabeth Liddle
Author: Suzanne McCarthy
Author: Antje Neubert
Author: Peter Nagy
Author: Eric Rosenthal
Author: Edmund J.S. Sonuga-Barke
Author: Ian C.K. Wong
Author: Tobias Banaschewski
Author: David Coghill
Corporate Author: The ADDUCE consortium

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