The molecular determinants of microglial developmental dynamics
The molecular determinants of microglial developmental dynamics
Microglia constitute the largest population of parenchymal macrophages in the brain and are considered a unique subset of central nervous system glial cells owing to their extra-embryonic origins in the yolk sac. During development, microglial progenitors readily proliferate and eventually colonize the entire brain. In this Review, we highlight the origins of microglial progenitors and their entry routes into the brain and discuss the various molecular and non-molecular determinants of their fate, which may inform their specific functions. Specifically, we explore recently identified mechanisms that regulate microglial colonization of the brain, including the availability of space, and describe how the expansion of highly proliferative microglial progenitors facilitates the occupation of the microglial niche. Finally, we shed light on the factors involved in establishing microglial identity in the brain.
414-427
Barry-Carroll, Liam
2ea75b82-34cd-4283-9d28-8ac0f7a2bbde
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Barry-Carroll, Liam
2ea75b82-34cd-4283-9d28-8ac0f7a2bbde
Gomez-Nicola, Diego
0680aa66-9dee-47cf-a8d3-e39c988f85b5
Barry-Carroll, Liam and Gomez-Nicola, Diego
(2024)
The molecular determinants of microglial developmental dynamics.
Nature Reviews Neuroscience, 25, .
(doi:10.1038/s41583-024-00813-1).
Abstract
Microglia constitute the largest population of parenchymal macrophages in the brain and are considered a unique subset of central nervous system glial cells owing to their extra-embryonic origins in the yolk sac. During development, microglial progenitors readily proliferate and eventually colonize the entire brain. In this Review, we highlight the origins of microglial progenitors and their entry routes into the brain and discuss the various molecular and non-molecular determinants of their fate, which may inform their specific functions. Specifically, we explore recently identified mechanisms that regulate microglial colonization of the brain, including the availability of space, and describe how the expansion of highly proliferative microglial progenitors facilitates the occupation of the microglial niche. Finally, we shed light on the factors involved in establishing microglial identity in the brain.
Text
Barry-Carroll & Gomez-Nicola 2024
- Author's Original
More information
Accepted/In Press date: 21 March 2024
e-pub ahead of print date: 24 April 2024
Identifiers
Local EPrints ID: 488991
URI: http://eprints.soton.ac.uk/id/eprint/488991
ISSN: 1471-0048
PURE UUID: c2a1558e-cf61-4464-866f-9d7e5840ae8d
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Date deposited: 10 Apr 2024 16:56
Last modified: 02 Nov 2024 02:44
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Author:
Liam Barry-Carroll
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