Aneuploidy and complex genomic rearrangements in cancer evolution
Aneuploidy and complex genomic rearrangements in cancer evolution
Mutational processes that alter large genomic regions occur frequently in developing tumors. They range from simple copy number gains and losses to the shattering and reassembly of entire chromosomes. These catastrophic events, such as chromothripsis, chromoplexy and the formation of extrachromosomal DNA, affect the expression of many genes and therefore have a substantial effect on the fitness of the cells in which they arise. In this review, we cover large genomic alterations, the mechanisms that cause them and their effect on tumor development and evolution.
228-239
Baker, Toby M.
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Waise, Sara
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Tarabichi, Maxime
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Van Loo, Peter
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February 2024
Baker, Toby M.
6c77fa83-e262-470c-9d1e-1841e39c5391
Waise, Sara
13f667c5-853e-4120-a2c6-bbc8324e3b2a
Tarabichi, Maxime
c2f05bf6-48eb-4df1-a2ed-a912b18cfdb6
Van Loo, Peter
8628fd72-0000-4110-a0d4-4f78eecfb800
Baker, Toby M., Waise, Sara, Tarabichi, Maxime and Van Loo, Peter
(2024)
Aneuploidy and complex genomic rearrangements in cancer evolution.
Nature cancer, 5 (2), .
(doi:10.1038/s43018-023-00711-y).
Abstract
Mutational processes that alter large genomic regions occur frequently in developing tumors. They range from simple copy number gains and losses to the shattering and reassembly of entire chromosomes. These catastrophic events, such as chromothripsis, chromoplexy and the formation of extrachromosomal DNA, affect the expression of many genes and therefore have a substantial effect on the fitness of the cells in which they arise. In this review, we cover large genomic alterations, the mechanisms that cause them and their effect on tumor development and evolution.
Text
Van_Loo_Review
- Accepted Manuscript
More information
Accepted/In Press date: 14 December 2023
e-pub ahead of print date: 29 January 2024
Published date: February 2024
Additional Information:
Publisher Copyright:
© Springer Nature America, Inc 2024.
Identifiers
Local EPrints ID: 489278
URI: http://eprints.soton.ac.uk/id/eprint/489278
ISSN: 2662-1347
PURE UUID: 239d9a03-0f78-4461-8335-0b69d2d0af00
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Date deposited: 19 Apr 2024 16:32
Last modified: 06 Jun 2024 16:52
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Contributors
Author:
Toby M. Baker
Author:
Sara Waise
Author:
Maxime Tarabichi
Author:
Peter Van Loo
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