Acquisition of peak bone mass in a Norwegian youth cohort: longitudinal findings from the Fit Futures study 2010-2022
Acquisition of peak bone mass in a Norwegian youth cohort: longitudinal findings from the Fit Futures study 2010-2022
Summary : in a Norwegian youth cohort followed from adolescence to young adulthood, bone mineral density (BMD) levels declined at the femoral neck and total hip from 16 to 27 years but continued to increase at the total body indicating a site-specific attainment of peak bone mass.
Purpose: to examine longitudinal trends in bone mineral density (BMD) levels in Norwegian adolescents into young adulthood.
Method: in a prospective cohort design, we followed 980 adolescents (473 (48%) females) aged 16–19 years into adulthood (age of 26–29) on three occasions: 2010–2011 (Fit Futures 1 (FF1)), 2012–2013 (FF2), and 2021–2022 (FF3), measuring BMD (g/cm 2) at the femoral neck, total hip, and total body with dual x-ray absorptiometry (DXA). We used linear mixed models to examine longitudinal BMD changes from FF1 to FF3.
Results: from the median age of 16 years (FF1), femoral neck BMD (mean g/cm 2 (95% CI)) slightly increased in females from 1.070 (1.059–1.082) to 1.076 (1.065–1.088, p = 0.015) at the median age of 18 years (FF2) but declined to 1.041 (1.029–1.053, p < 0.001) at the median age of 27 years (FF3). Similar patterns were observed in males: 16 years, 1.104 (1.091–1.116); 27 years, 1.063 (1.050–1.077, p < 0.001); and for the total hip in both sexes (both p < 0.001). Total body BMD increased from age 16 to 27 years in both sexes (females: 16 years, 1.141 (1.133–1.148); 27 years, 1.204 (1.196–1.212), p < 0.001; males: 16 years, 1.179 (1.170–1.188); 27 years, 1.310 (1.296–1.315), p < 0.001).
Conclusion: BMD levels increased from 16 to 18 years at the femoral and total hip sites in young Norwegian females and males, and a small decline was observed at the femoral sites when the participants were followed up to 27 years. Total body BMD continued to increase from adolescence to young adulthood.
Absorptiometry, Photon, Adolescent, Adult, Bone Density, Cohort Studies, Female, Femur Neck/diagnostic imaging, Humans, Longitudinal Studies, Male, Norway/epidemiology, Prospective Studies, Young Adult, Peak bone mass, Population-based study, Young adulthood, Bone mineral density, Adolescents
Sagelv, Edvard H.
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Emaus, Nina
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Evensen, Elin
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Christoffersen, Tore
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Dennison, Elaine
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Furberg, Anne-Sofie
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Grimnes, Guri
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Johansson, Jonas
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Nielsen, Christopher Sivert
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Nilsen, Ole Andreas
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Winther, Anne
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Sagelv, Edvard H.
925569d5-3f49-4e7a-82e6-133f45a2a344
Emaus, Nina
fa8b8643-dc1b-462c-9e69-e8923b2115fd
Evensen, Elin
345ede1e-a343-468c-92bf-aabd1a1bb071
Christoffersen, Tore
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Dennison, Elaine
ee647287-edb4-4392-8361-e59fd505b1d1
Furberg, Anne-Sofie
1a5a184e-be6d-4559-a706-9e4703bba170
Grimnes, Guri
a51f752e-ee2a-4033-9691-66b6f35a544d
Johansson, Jonas
ebab2ebf-9464-4eb3-8ddb-9d0eaefdefcc
Nielsen, Christopher Sivert
dfc9f7c2-86b2-458e-8191-7db271a0bc60
Nilsen, Ole Andreas
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Winther, Anne
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Sagelv, Edvard H., Emaus, Nina, Evensen, Elin, Christoffersen, Tore, Dennison, Elaine, Furberg, Anne-Sofie, Grimnes, Guri, Johansson, Jonas, Nielsen, Christopher Sivert, Nilsen, Ole Andreas and Winther, Anne
(2024)
Acquisition of peak bone mass in a Norwegian youth cohort: longitudinal findings from the Fit Futures study 2010-2022.
Archives of Osteoporosis, 19 (1), [58].
(doi:10.1007/s11657-024-01414-2).
Abstract
Summary : in a Norwegian youth cohort followed from adolescence to young adulthood, bone mineral density (BMD) levels declined at the femoral neck and total hip from 16 to 27 years but continued to increase at the total body indicating a site-specific attainment of peak bone mass.
Purpose: to examine longitudinal trends in bone mineral density (BMD) levels in Norwegian adolescents into young adulthood.
Method: in a prospective cohort design, we followed 980 adolescents (473 (48%) females) aged 16–19 years into adulthood (age of 26–29) on three occasions: 2010–2011 (Fit Futures 1 (FF1)), 2012–2013 (FF2), and 2021–2022 (FF3), measuring BMD (g/cm 2) at the femoral neck, total hip, and total body with dual x-ray absorptiometry (DXA). We used linear mixed models to examine longitudinal BMD changes from FF1 to FF3.
Results: from the median age of 16 years (FF1), femoral neck BMD (mean g/cm 2 (95% CI)) slightly increased in females from 1.070 (1.059–1.082) to 1.076 (1.065–1.088, p = 0.015) at the median age of 18 years (FF2) but declined to 1.041 (1.029–1.053, p < 0.001) at the median age of 27 years (FF3). Similar patterns were observed in males: 16 years, 1.104 (1.091–1.116); 27 years, 1.063 (1.050–1.077, p < 0.001); and for the total hip in both sexes (both p < 0.001). Total body BMD increased from age 16 to 27 years in both sexes (females: 16 years, 1.141 (1.133–1.148); 27 years, 1.204 (1.196–1.212), p < 0.001; males: 16 years, 1.179 (1.170–1.188); 27 years, 1.310 (1.296–1.315), p < 0.001).
Conclusion: BMD levels increased from 16 to 18 years at the femoral and total hip sites in young Norwegian females and males, and a small decline was observed at the femoral sites when the participants were followed up to 27 years. Total body BMD continued to increase from adolescence to young adulthood.
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s11657-024-01414-2
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Accepted/In Press date: 20 June 2024
e-pub ahead of print date: 3 July 2024
Keywords:
Absorptiometry, Photon, Adolescent, Adult, Bone Density, Cohort Studies, Female, Femur Neck/diagnostic imaging, Humans, Longitudinal Studies, Male, Norway/epidemiology, Prospective Studies, Young Adult, Peak bone mass, Population-based study, Young adulthood, Bone mineral density, Adolescents
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Local EPrints ID: 492465
URI: http://eprints.soton.ac.uk/id/eprint/492465
ISSN: 1862-3522
PURE UUID: 3b6cbb1c-d598-4268-b27f-78aaeefa3d1f
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Date deposited: 29 Jul 2024 16:54
Last modified: 13 Aug 2024 01:34
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Contributors
Author:
Edvard H. Sagelv
Author:
Nina Emaus
Author:
Elin Evensen
Author:
Tore Christoffersen
Author:
Anne-Sofie Furberg
Author:
Guri Grimnes
Author:
Jonas Johansson
Author:
Christopher Sivert Nielsen
Author:
Ole Andreas Nilsen
Author:
Anne Winther
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