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Kidney Beam - a cost-effective digital intervention to improve mental health

Kidney Beam - a cost-effective digital intervention to improve mental health
Kidney Beam - a cost-effective digital intervention to improve mental health
Introduction: there is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD.

Methods: in a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention.

Results: at 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained.

Conclusion: the Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).
chronic kidney disease, cost-effectiveness, digital health intervention, physical activity, quality of life
2468-0249
Greenwood, Sharlene A.
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Briggs, Juliet
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Walklin, Christy G.
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Mangahis, Emmanuel
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Young, Hannah M.
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Castle, Ellen M.
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Billany, Roseanne
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Asgari, Elham
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Bhandari, Sunil
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Bishop, Nicolette
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Bramham, Kate
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Burton, James
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Campbell, Jackie
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Campbell, Jackie
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Chilcot, Joseph
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Cooper, Nicola
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Deelchand, Vashist
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Graham-Brown, Matthew
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Haggis, Lynda
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Hamilton, Alexander J.
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Jesky, Mark
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Kalra, Phillip A.
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Koufaki, Pelagia
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Mccafferty, Kieran
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Nixon, Andrew C.
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Noble, Helen R.
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Saynor, Zoe
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Taal, Maarten W.
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Tolitt, James
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Wheeler, David C.
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Wilkinson, Thomas
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Worboys, Hannah
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Macdonald, Jamie H.
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Greenwood, Sharlene A.
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Briggs, Juliet
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Walklin, Christy G.
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Mangahis, Emmanuel
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Young, Hannah M.
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Castle, Ellen M.
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Billany, Roseanne
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Asgari, Elham
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Bhandari, Sunil
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Bishop, Nicolette
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Bramham, Kate
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Burton, James
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Campbell, Jackie
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Campbell, Jackie
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Chilcot, Joseph
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Cooper, Nicola
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Deelchand, Vashist
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Graham-Brown, Matthew
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Haggis, Lynda
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Hamilton, Alexander J.
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Jesky, Mark
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Kalra, Phillip A.
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Koufaki, Pelagia
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Mccafferty, Kieran
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Nixon, Andrew C.
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Noble, Helen R.
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Saynor, Zoe
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Taal, Maarten W.
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Tolitt, James
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Wheeler, David C.
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Wilkinson, Thomas
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Worboys, Hannah
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Macdonald, Jamie H.
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Greenwood, Sharlene A., Briggs, Juliet, Walklin, Christy G., Mangahis, Emmanuel, Young, Hannah M., Castle, Ellen M., Billany, Roseanne, Asgari, Elham, Bhandari, Sunil, Bishop, Nicolette, Bramham, Kate, Burton, James, Campbell, Jackie, Campbell, Jackie, Chilcot, Joseph, Cooper, Nicola, Deelchand, Vashist, Graham-Brown, Matthew, Haggis, Lynda, Hamilton, Alexander J., Jesky, Mark, Kalra, Phillip A., Koufaki, Pelagia, Mccafferty, Kieran, Nixon, Andrew C., Noble, Helen R., Saynor, Zoe, Taal, Maarten W., Tolitt, James, Wheeler, David C., Wilkinson, Thomas, Worboys, Hannah and Macdonald, Jamie H. (2024) Kidney Beam - a cost-effective digital intervention to improve mental health. Kidney International Reports. (doi:10.1016/j.ekir.2024.08.030).

Record type: Article

Abstract

Introduction: there is inequity in the provision of physical rehabilitation services for people living with chronic kidney disease (CKD). The Kidney BEAM trial evaluated the clinical value and cost effectiveness of a physical activity digital health intervention (DHI) in CKD.

Methods: in a single-blind, 11 center, randomized controlled trial, 340 adult participants with CKD were randomly assigned to either the Kidney BEAM physical activity DHI or a waitlist control. This study assessed the difference in the Kidney Disease Quality of Life Short Form 1.3 Mental Component Summary (KDQoL-SF1.3 MCS) between intervention and control groups at 6-months, and cost-effectiveness of the intervention.

Results: at 6-months, there was a significant difference in mean adjusted change in KDQoL MCS score between Kidney BEAM and waitlist control (intention-to-treat adjusted mean: 5.9 [95% confidence interval, CI: 4.4–7.5] arbitrary units [AU], P < 0.0001), and a 93% and 98% chance of the intervention being cost-effective at a willingness-to-pay threshold of £20,000 and £30,000 per quality-adjusted life year gained.

Conclusion: the Kidney BEAM physical activity DHI is a clinically valuable and cost-effective means to improve mental health-related quality of life (HRQoL) in people with CKD (trial registration no. NCT04872933).

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Accepted/In Press date: 25 August 2024
e-pub ahead of print date: 2 September 2024
Keywords: chronic kidney disease, cost-effectiveness, digital health intervention, physical activity, quality of life
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Identifiers

Local EPrints ID: 493875
URI: http://eprints.soton.ac.uk/id/eprint/493875
DOI: doi:10.1016/j.ekir.2024.08.030
ISSN: 2468-0249
PURE UUID: f74a71e3-9eaa-46d8-908b-50c6d77a6f9a
ORCID for Zoe Saynor: ORCID iD orcid.org/0000-0003-0674-8477

Catalogue record

Date deposited: 16 Sep 2024 16:47
Last modified: 01 Oct 2024 02:13

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Contributors

Author: Sharlene A. Greenwood
Author: Juliet Briggs
Author: Christy G. Walklin
Author: Emmanuel Mangahis
Author: Hannah M. Young
Author: Ellen M. Castle
Author: Roseanne Billany
Author: Elham Asgari
Author: Sunil Bhandari
Author: Nicolette Bishop
Author: Kate Bramham
Author: James Burton
Author: Jackie Campbell
Author: Jackie Campbell
Author: Joseph Chilcot
Author: Nicola Cooper
Author: Vashist Deelchand
Author: Matthew Graham-Brown
Author: Lynda Haggis
Author: Alexander J. Hamilton
Author: Mark Jesky
Author: Phillip A. Kalra
Author: Pelagia Koufaki
Author: Kieran Mccafferty
Author: Andrew C. Nixon
Author: Helen R. Noble
Author: Zoe Saynor ORCID iD
Author: Maarten W. Taal
Author: James Tolitt
Author: David C. Wheeler
Author: Thomas Wilkinson
Author: Hannah Worboys
Author: Jamie H. Macdonald

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