Modelling enzyme electrodes – what do we learn and how is it useful?
Modelling enzyme electrodes – what do we learn and how is it useful?
There has been an enormous increase in the computational power readily available since the first numerical treatments of electrochemical problems in the early 1960s. This development has been accompanied by the development of powerful, widely available, commercial software modelling tools. Despite this, approximate analytical treatments remain extremely useful in the modelling of coupled diffusion/reaction problems in electrochemistry because of the insights they provide into the different possible behaviours of the system. In this paper we discuss the modelling of amperometric enzyme electrodes, taking as our exemplar redox hydrogel-based enzyme electrodes in which the enzyme is immobilized in a redox active polymer which wires the enzyme to the electrode. In this system the measured current is related to many different experimental variables including substrate concentration and diffusion coefficient, reaction rate constants, and film properties and thickness. The interplay of these factors is described and the role of Case diagrams in understanding coupled diffusion/reaction problems of this type is discussed.
Case diagram, Enzyme electrode, Modelling, Redox-hydrogel
Bartlett, Philip N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Khan, M. Hashim
50ef163a-21c0-4ba8-a21f-2c4fa473e19d
27 February 2025
Bartlett, Philip N.
d99446db-a59d-4f89-96eb-f64b5d8bb075
Khan, M. Hashim
50ef163a-21c0-4ba8-a21f-2c4fa473e19d
Bartlett, Philip N. and Khan, M. Hashim
(2025)
Modelling enzyme electrodes – what do we learn and how is it useful?
Bioelectrochemistry, 165, [108941].
(doi:10.1016/j.bioelechem.2025.108941).
Abstract
There has been an enormous increase in the computational power readily available since the first numerical treatments of electrochemical problems in the early 1960s. This development has been accompanied by the development of powerful, widely available, commercial software modelling tools. Despite this, approximate analytical treatments remain extremely useful in the modelling of coupled diffusion/reaction problems in electrochemistry because of the insights they provide into the different possible behaviours of the system. In this paper we discuss the modelling of amperometric enzyme electrodes, taking as our exemplar redox hydrogel-based enzyme electrodes in which the enzyme is immobilized in a redox active polymer which wires the enzyme to the electrode. In this system the measured current is related to many different experimental variables including substrate concentration and diffusion coefficient, reaction rate constants, and film properties and thickness. The interplay of these factors is described and the role of Case diagrams in understanding coupled diffusion/reaction problems of this type is discussed.
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Accepted/In Press date: 10 February 2025
e-pub ahead of print date: 22 February 2025
Published date: 27 February 2025
Keywords:
Case diagram, Enzyme electrode, Modelling, Redox-hydrogel
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Local EPrints ID: 499957
URI: http://eprints.soton.ac.uk/id/eprint/499957
ISSN: 1567-5394
PURE UUID: 1c8bcd75-9256-4e57-bb92-3d649404bdcb
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Date deposited: 09 Apr 2025 18:47
Last modified: 22 Aug 2025 01:36
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Author:
M. Hashim Khan
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