Treatment considerations for severe osteoporosis in older adults
Treatment considerations for severe osteoporosis in older adults
Osteoporosis, a chronic metabolic bone disease, increases the predisposition to fragility fractures and is associated with considerable morbidity, high health care cost as well as mortality. An elevation in the rate of incident fragility fractures will be observed proportional with the increase in the number of older people worldwide. Severe osteoporosis is currently defined as having a bone density determined by dual-energy X-ray absorptiometry that is more than 2.5 standard deviations (SD) below the young adult mean with one or more past fractures due to osteoporosis. Nutrition, physical activity and adequate vitamin D are essential for optimal bone strength throughout life. Hormone (oestrogen/sex steroid) status is also a major determinant of bone health. This review explores mechanisms involved in bone homeostasis, followed by the assessment and management of severe osteoporosis, including an overview of several treatment options in older people that range from anti-resorptive to anabolic therapies.
395-412
See, Heidi
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Gowling, Emma
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Boswell, Evie
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Aggarwal, Pritti
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King, Katherine
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Smith, Nicola
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Lim, Stephen
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Baxter, Mark
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Patel, Harnish P.
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16 April 2025
See, Heidi
36be88aa-7c89-4ae2-a40f-24c71fff9c9b
Gowling, Emma
25a65c8b-48d8-4018-b3ad-459c84fad109
Boswell, Evie
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Aggarwal, Pritti
d13e6516-5b53-4789-b627-115fcebd0d2b
King, Katherine
6ad746d1-93b8-4ea0-bc20-bd8f9fe7fd8f
Smith, Nicola
923b9202-b626-4422-bd2f-529db992e98b
Lim, Stephen
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Baxter, Mark
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Patel, Harnish P.
e1c0826f-d14e-49f3-8049-5b945d185523
See, Heidi, Gowling, Emma, Boswell, Evie, Aggarwal, Pritti, King, Katherine, Smith, Nicola, Lim, Stephen, Baxter, Mark and Patel, Harnish P.
(2025)
Treatment considerations for severe osteoporosis in older adults.
Drugs & Aging, 42 (5), , [100097].
(doi:10.1007/s40266-025-01205-5).
Abstract
Osteoporosis, a chronic metabolic bone disease, increases the predisposition to fragility fractures and is associated with considerable morbidity, high health care cost as well as mortality. An elevation in the rate of incident fragility fractures will be observed proportional with the increase in the number of older people worldwide. Severe osteoporosis is currently defined as having a bone density determined by dual-energy X-ray absorptiometry that is more than 2.5 standard deviations (SD) below the young adult mean with one or more past fractures due to osteoporosis. Nutrition, physical activity and adequate vitamin D are essential for optimal bone strength throughout life. Hormone (oestrogen/sex steroid) status is also a major determinant of bone health. This review explores mechanisms involved in bone homeostasis, followed by the assessment and management of severe osteoporosis, including an overview of several treatment options in older people that range from anti-resorptive to anabolic therapies.
Text
CLEAN March 2025 Treatment Severe Osteoporosis HPP
- Accepted Manuscript
Text
s40266-025-01205-5
- Version of Record
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Accepted/In Press date: 26 March 2025
Published date: 16 April 2025
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For the purpose of Open Access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising from this submission.
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Local EPrints ID: 501421
URI: http://eprints.soton.ac.uk/id/eprint/501421
ISSN: 1170-229X
PURE UUID: 91ace506-5c9c-4f23-a282-bc38582cb306
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Date deposited: 30 May 2025 16:56
Last modified: 03 Sep 2025 01:47
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Author:
Heidi See
Author:
Emma Gowling
Author:
Evie Boswell
Author:
Katherine King
Author:
Nicola Smith
Author:
Mark Baxter
Author:
Harnish P. Patel
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