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Data is support of the thesis: Synthesis and Biological Characterisation of Cyclic Peptide PROTACs of Hypoxia Inducible Factor 1 alpha

Data is support of the thesis: Synthesis and Biological Characterisation of Cyclic Peptide PROTACs of Hypoxia Inducible Factor 1 alpha
Data is support of the thesis: Synthesis and Biological Characterisation of Cyclic Peptide PROTACs of Hypoxia Inducible Factor 1 alpha
This dataset contains: Luciferase data - contains luciferase assay data for both cell viability and activity assays that is recorded on GraphPad. MST - contains KDs for compounds that bound to HIF-1a, also recorded on GraphPad. qPCR - contains gene expression response in cancer cells to treatment with cyclic peptide PROTACs. Data analysed on GraphPad. Western blot - contains information about the degradation of HIF-1a in cancer cells. Measured using Empiria Studio and data analysed quantitatively on GraphPad. NMR characterisation - contains characterisation data of compounds analysed on ACD labs.
University of Southampton
McDermott, Alexander
2f71eef3-a08b-4699-bd2f-7c84c8e1a87e
McDermott, Alexander
2f71eef3-a08b-4699-bd2f-7c84c8e1a87e

McDermott, Alexander (2026) Data is support of the thesis: Synthesis and Biological Characterisation of Cyclic Peptide PROTACs of Hypoxia Inducible Factor 1 alpha. University of Southampton doi:10.5258/SOTON/D3512 [Dataset]

Record type: Dataset

Abstract

This dataset contains: Luciferase data - contains luciferase assay data for both cell viability and activity assays that is recorded on GraphPad. MST - contains KDs for compounds that bound to HIF-1a, also recorded on GraphPad. qPCR - contains gene expression response in cancer cells to treatment with cyclic peptide PROTACs. Data analysed on GraphPad. Western blot - contains information about the degradation of HIF-1a in cancer cells. Measured using Empiria Studio and data analysed quantitatively on GraphPad. NMR characterisation - contains characterisation data of compounds analysed on ACD labs.

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READ_ME_File_For_Dataset_Synthesis_and_biological_characterisation_of_cyclic_peptide_PROTACs_targeting_hypoxia_inducible_factor_1_alpha.txt - Dataset
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Thesis_SI.docx - Dataset
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Luciferase.zip - Dataset
Restricted to System admin until 3 June 2026.
Available under License Creative Commons Attribution.
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MST.zip - Dataset
Restricted to System admin until 3 June 2026.
Available under License Creative Commons Attribution.
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qPCR.zip - Dataset
Restricted to System admin until 3 June 2026.
Available under License Creative Commons Attribution.
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Western_Blot.zip - Dataset
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Available under License Creative Commons Attribution.
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NMR_Characterisation.zip - Dataset
Restricted to System admin until 3 June 2026.
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Published date: 10 June 2026
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Identifiers

Local EPrints ID: 502045
URI: http://eprints.soton.ac.uk/id/eprint/502045
DOI: doi:10.5258/SOTON/D3512
PURE UUID: 14e06acf-f3b1-4c92-af21-bb388ec1eabe

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Date deposited: 13 Jun 2025 17:42
Last modified: 13 Jun 2025 17:42

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Contributors

Creator: Alexander McDermott

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