Osteoporosis and fracture risk: a practical guide for neurologists
Osteoporosis and fracture risk: a practical guide for neurologists
Many people with neurological disorders are at high risk of osteoporosis and fragility fractures. Such fractures are a leading cause of disability and premature mortality. There are various underlying mechanisms, including reduced bone mineral density from biomechanical factors (eg, reduced muscle strength), inflammation and/or medications such as glucocorticoids, together with an increased risk of falls. Neurologists are well placed to initiate measures to protect bone health. In this review, we address the epidemiological associations between bone health, fracture risk and different neurological disorders and elucidate the potential underlying mechanisms. We set out overarching principles for managing bone health in the context of neurological disorders, together with guidance for specific diseases.
CLINICAL NEUROLOGY, EPIDEMIOLOGY
Laskou, Faidra
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Curtis, Elizabeth M.
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Varatharaj, Aravinthan
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Dennison, Elaine M.
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Harvey, Nicholas C.
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2025
Laskou, Faidra
ea7e7a54-092d-4baf-8b18-e0d62c47b878
Curtis, Elizabeth M.
6e344d0a-3893-4dd5-88ca-4cad00558cce
Varatharaj, Aravinthan
33d833af-9459-4b21-8489-ce9c0b6a09e0
Dennison, Elaine M.
ee647287-edb4-4392-8361-e59fd505b1d1
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Laskou, Faidra, Curtis, Elizabeth M., Varatharaj, Aravinthan, Dennison, Elaine M. and Harvey, Nicholas C.
(2025)
Osteoporosis and fracture risk: a practical guide for neurologists.
Practical Neurology.
(doi:10.1136/pn-2024-004257).
Abstract
Many people with neurological disorders are at high risk of osteoporosis and fragility fractures. Such fractures are a leading cause of disability and premature mortality. There are various underlying mechanisms, including reduced bone mineral density from biomechanical factors (eg, reduced muscle strength), inflammation and/or medications such as glucocorticoids, together with an increased risk of falls. Neurologists are well placed to initiate measures to protect bone health. In this review, we address the epidemiological associations between bone health, fracture risk and different neurological disorders and elucidate the potential underlying mechanisms. We set out overarching principles for managing bone health in the context of neurological disorders, together with guidance for specific diseases.
Text
Practical neurology_osteoporosis_Pure
- Accepted Manuscript
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Accepted/In Press date: 29 May 2025
Published date: 2025
Keywords:
CLINICAL NEUROLOGY, EPIDEMIOLOGY
Identifiers
Local EPrints ID: 504163
URI: http://eprints.soton.ac.uk/id/eprint/504163
ISSN: 1474-7758
PURE UUID: afe3ba31-a310-4c46-8117-791c957b746d
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Date deposited: 28 Aug 2025 16:40
Last modified: 30 Sep 2025 02:16
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Author:
Faidra Laskou
Author:
Elizabeth M. Curtis
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