Preliminary considerations on principles for the determination of difficult bubble parameters in situ through Megafrexel high speed photographic observation

Abstract

An increasing number of laboratories have the facilities to take high speed
photographs of the pulsations of microbubbles to a degree not previously possible.
Together with the advent of ultrasonic contrast agents which are stable over a long
period, and the use of techniques to locate them within the field of view, these
experimental utilities enable movies to be made of the pulsation of bubbles with much
finer spatial and temporal scales. The quantitative analysis of such movies, if it
occurs, relies on fitting with models that contain several unknowns. This paper
discusses in a preliminary manner how such movies can be interpreted in a way which
reduces the reliance on uncertain fits of models to data, given that the movie provides
basic dynamic information in the form of a time step and a bubble size and shape. If
the driving acoustic field, including its phase with respect to the movie frames, is
recorded, then the movie data can be interpreted directly in terms of key bubble
parameters without fitting.

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ORCID for T.G. Leighton: orcid.org/0000-0002-1649-8750

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