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When load doesn’t tell the whole story: acute effects of effort matched resistance training protocols on arterial stiffness

When load doesn’t tell the whole story: acute effects of effort matched resistance training protocols on arterial stiffness
When load doesn’t tell the whole story: acute effects of effort matched resistance training protocols on arterial stiffness
This study examined acute vascular responses to three resistance training (RT) protocols differing in load and volume but matched for proximity to failure. Eleven adults (6 males and 5 females) performed three RT protocols consisting of the hexagonal deadlift and bench pull exercises with the following: (i). Low-volume, moderate-load, and high-repetition (Condition A: 2 × 10 repetitions), (ii). Low-volume, high-load, and low-repetition (Condition B: 2 × 4 repetitions), and (iii). Moderate-volume, high-load, and low-repetition (Condition C: 5 × 4 repetitions). Proximity to failure was set at 2 repetitions in reserve. Measurements of carotid-femoral pulse wave velocity (cfPWV) and pulse wave analysis (e.g., augmentation index) were collected at baseline, immediately post, and 15 min posttraining, whereas muscle oxygenation was monitored during performance the hexagonal deadlift. Condition A induced significantly greater increases in cfPWV (6.2 ± 0.6 to 6.9 ± 0.8 m/s) when compared to both Condition B (6.5 ± 0.8 to 6.4 ± 0.7 m/s) and Condition C (6.3 ± 0.8 to 6.4 ± 0.6 m/s), (all p < 0.05). No significant changes were observed in muscle oxygenation variables across conditions. These findings suggest that the number of repetitions per set and total time under tension (Condition A), rather than absolute load or set volume, play a more important role in mediating acute hemodynamic responses following RT.
central haemodynamics, proximity to failure, pulse wave velocity, repetitions in reserve
1746-1391
Karanasios, Eleftherios
d6f3963c-092c-473b-97f5-880cd065f154
Faulkner, James
b2bd38c9-667c-42e8-ad1e-6df58d1e3f7a
Scott, Hannah
44ee45c4-6259-4948-9d3b-60f0fc135137
Karanasios, Eleftherios
d6f3963c-092c-473b-97f5-880cd065f154
Faulkner, James
b2bd38c9-667c-42e8-ad1e-6df58d1e3f7a
Scott, Hannah
44ee45c4-6259-4948-9d3b-60f0fc135137

Karanasios, Eleftherios, Faulkner, James and Scott, Hannah (2026) When load doesn’t tell the whole story: acute effects of effort matched resistance training protocols on arterial stiffness. European Journal of Sport Science, 26 (4), [e70164]. (doi:10.1002/ejsc.70164).

Record type: Article

Abstract

This study examined acute vascular responses to three resistance training (RT) protocols differing in load and volume but matched for proximity to failure. Eleven adults (6 males and 5 females) performed three RT protocols consisting of the hexagonal deadlift and bench pull exercises with the following: (i). Low-volume, moderate-load, and high-repetition (Condition A: 2 × 10 repetitions), (ii). Low-volume, high-load, and low-repetition (Condition B: 2 × 4 repetitions), and (iii). Moderate-volume, high-load, and low-repetition (Condition C: 5 × 4 repetitions). Proximity to failure was set at 2 repetitions in reserve. Measurements of carotid-femoral pulse wave velocity (cfPWV) and pulse wave analysis (e.g., augmentation index) were collected at baseline, immediately post, and 15 min posttraining, whereas muscle oxygenation was monitored during performance the hexagonal deadlift. Condition A induced significantly greater increases in cfPWV (6.2 ± 0.6 to 6.9 ± 0.8 m/s) when compared to both Condition B (6.5 ± 0.8 to 6.4 ± 0.7 m/s) and Condition C (6.3 ± 0.8 to 6.4 ± 0.6 m/s), (all p < 0.05). No significant changes were observed in muscle oxygenation variables across conditions. These findings suggest that the number of repetitions per set and total time under tension (Condition A), rather than absolute load or set volume, play a more important role in mediating acute hemodynamic responses following RT.

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Accepted/In Press date: 17 March 2026
e-pub ahead of print date: 24 March 2026
Published date: 24 March 2026
Keywords: central haemodynamics, proximity to failure, pulse wave velocity, repetitions in reserve

Identifiers

Local EPrints ID: 510958
URI: http://eprints.soton.ac.uk/id/eprint/510958
ISSN: 1746-1391
PURE UUID: 068bb67a-2dca-4233-bd60-109d8a20c38a
ORCID for James Faulkner: ORCID iD orcid.org/0000-0002-3704-6737

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Date deposited: 28 Apr 2026 16:30
Last modified: 29 Apr 2026 02:15

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Contributors

Author: Eleftherios Karanasios
Author: James Faulkner ORCID iD
Author: Hannah Scott

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