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Integrated optical fluorescence multi-sensor system

Integrated optical fluorescence multi-sensor system
Integrated optical fluorescence multi-sensor system
Research on fluorescence-based integrated optical immunoassay multisensing systems has gained growing interest in the last ten years. This is because the systems have the potential to simultaneously detect multiple analytes in a single measurement, and the techniques involved are fast, robust and cost-effective. Therefore they have the potential to replace conventional chromatographic techniques, as the monitoring systems for the rapid assessment of water or food samples. Other areas, such as clinical diagnostics or forensic science also have a demand for highly multiplexed analytical systems. This thesis presents a novel 32-analyte integrated optical fluorescence-based multisensor, and its integration to an automated multi-bio-sensing system. This system is primarily used for detecting organic pollutants in river water. A detailed study was also carried out with a CCD detector system, used to replace the fibre collection and photodiode array system and allow straight forward extension to more than 32 analytes. A direct comparison between these two systems is also presented.
Hua, Ping
92fa76e2-970b-45f5-a459-d9f95e735303
Hua, Ping
92fa76e2-970b-45f5-a459-d9f95e735303

Hua, Ping (2009) Integrated optical fluorescence multi-sensor system. University of Southampton, Optoelectronic Research Centre, Doctoral Thesis, 164pp.

Record type: Thesis (Doctoral)

Abstract

Research on fluorescence-based integrated optical immunoassay multisensing systems has gained growing interest in the last ten years. This is because the systems have the potential to simultaneously detect multiple analytes in a single measurement, and the techniques involved are fast, robust and cost-effective. Therefore they have the potential to replace conventional chromatographic techniques, as the monitoring systems for the rapid assessment of water or food samples. Other areas, such as clinical diagnostics or forensic science also have a demand for highly multiplexed analytical systems. This thesis presents a novel 32-analyte integrated optical fluorescence-based multisensor, and its integration to an automated multi-bio-sensing system. This system is primarily used for detecting organic pollutants in river water. A detailed study was also carried out with a CCD detector system, used to replace the fibre collection and photodiode array system and allow straight forward extension to more than 32 analytes. A direct comparison between these two systems is also presented.

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Published date: 2009
Organisations: University of Southampton

Identifiers

Local EPrints ID: 70934
URI: http://eprints.soton.ac.uk/id/eprint/70934
PURE UUID: d1caa80f-3ae1-4580-baba-4e099a2d2399

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Date deposited: 11 Dec 2009
Last modified: 29 Jan 2020 13:04

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