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In-silico wear prediction for knee replacements - methodology and corroboration

Strickland, M.A. and Taylor, M. (2009) In-silico wear prediction for knee replacements - methodology and corroboration Journal of Biomechanics, 42, (10), pp. 1469-1474. (doi:10.1016/j.jbiomech.2009.04.022). (PMID:19464013).

Record type: Article

Abstract

The capability to predict in-vivo wear of knee replacements is a valuable pre-clinical analysis tool for implant designers. Traditionally, time-consuming experimental tests provided the principal means of investigating wear. Today, computational models offer an alternative. However, the validity of these models has not been demonstrated across a range of designs and test conditions, and several different formulas are in contention for estimating wear rates, limiting confidence in the predictive power of these in-silico models.

This study collates and retrospectively simulates a wide range of experimental wear tests using fast rigid-body computational models with extant wear prediction algorithms, to assess the performance of current in-silico wear prediction tools.

The number of tests corroborated gives a broader, more general assessment of the performance of these wear-prediction tools, and provides better estimates of the wear ‘constants’ used in computational models. High-speed rigid-body modelling allows a range of alternative algorithms to be evaluated. Whilst most cross-shear (CS)-based models perform comparably, the ‘A/A+B’ wear model appears to offer the best predictive power amongst existing wear algorithms. However, the range and variability of experimental data leaves considerable uncertainty in the results. More experimental data with reduced variability and more detailed reporting of studies will be necessary to corroborate these models with greater confidence. With simulation times reduced to only a few minutes, these models are ideally suited to large-volume ‘design of experiment’ or probabilistic studies (which are essential if pre-clinical assessment tools are to begin addressing the degree of variation observed clinically and in explanted components)

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More information

Published date: 22 July 2009
Keywords: knee, tkr, wear, mechanics, computational, experimental, validation, corroboration
Organisations: Bioengineering Group

Identifiers

Local EPrints ID: 72074
URI: http://eprints.soton.ac.uk/id/eprint/72074
ISSN: 0021-9290
PURE UUID: 841660cb-c277-4cec-90fe-3ee22379e011

Catalogue record

Date deposited: 20 Jan 2010
Last modified: 18 Jul 2017 23:56

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