Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom
Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom
Background:Fractures are common in childhood, and there is considerable variation in the reported incidence across European countries, but few data relating to ethnic and geographic differences within a single country. We therefore aimed to determine the incidence of childhood fractures in the United Kingdom (UK), and to describe age-, ethnicity- and region- specific variations.
Methods:The Clinical Practice Research Datalink (CPRD) contains anonymised electronic health records for approximately 7% of the UK population. The occurrence of a fracture between 1988 and 2012 was determined from the CPRD for all individuals < 18 years of age, and used to calculate fracture incidence rates for age, sex and ethnicity. Regional fracture incidence rates were also calculated based on general practitioner location within 14 Strategic Health Authorities (SHA) within the UK.
Results: The overall fracture incidence rate was 137 per 10,000 person-years (py). This was higher in boys (169 per 10,000 py) than girls (103 per 10,000 py) and white children (150 per 10,000 py) compared to those of black (64 per 10,000 py) and South Asian (81 per 10,000 py) ethnicity. Marked geographic variation in incidence was observed. The highest fracture rates were observed in Wales, where boys and girls had 1.82 and 1.97 times greater incidence, respectively, than those residing in Greater London.
Conclusion: In the period 1988–2012, there was marked geographic and ethnic variation in childhood fracture incidence across the UK. These findings also implicate lifestyle and socio-economic differences associated with location and ethnicity, and are relevant to policy makers in the UK and internationally.
fracture, children, epidemiology, osteoporosis, ethnicity, cprd
9-14
Moon, R.J.
954fb3ed-9934-4649-886d-f65944985a6b
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Curtis, E.M.
92beef1b-f012-4398-861c-e1156b2adfee
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
van Staa, T.
7e263d59-ecc2-41f2-8b20-3f934d09c2c9
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
April 2016
Moon, R.J.
954fb3ed-9934-4649-886d-f65944985a6b
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Curtis, E.M.
92beef1b-f012-4398-861c-e1156b2adfee
de Vries, F.
db4c0543-d6e7-476b-a10e-52d9d483f613
van Staa, T.
7e263d59-ecc2-41f2-8b20-3f934d09c2c9
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Moon, R.J., Harvey, N.C., Curtis, E.M., de Vries, F., van Staa, T. and Cooper, C.
(2016)
Ethnic and geographic variations in the epidemiology of childhood fractures in the United Kingdom.
Bone, 85, .
(doi:10.1016/j.bone.2016.01.015).
(PMID:26802259)
Abstract
Background:Fractures are common in childhood, and there is considerable variation in the reported incidence across European countries, but few data relating to ethnic and geographic differences within a single country. We therefore aimed to determine the incidence of childhood fractures in the United Kingdom (UK), and to describe age-, ethnicity- and region- specific variations.
Methods:The Clinical Practice Research Datalink (CPRD) contains anonymised electronic health records for approximately 7% of the UK population. The occurrence of a fracture between 1988 and 2012 was determined from the CPRD for all individuals < 18 years of age, and used to calculate fracture incidence rates for age, sex and ethnicity. Regional fracture incidence rates were also calculated based on general practitioner location within 14 Strategic Health Authorities (SHA) within the UK.
Results: The overall fracture incidence rate was 137 per 10,000 person-years (py). This was higher in boys (169 per 10,000 py) than girls (103 per 10,000 py) and white children (150 per 10,000 py) compared to those of black (64 per 10,000 py) and South Asian (81 per 10,000 py) ethnicity. Marked geographic variation in incidence was observed. The highest fracture rates were observed in Wales, where boys and girls had 1.82 and 1.97 times greater incidence, respectively, than those residing in Greater London.
Conclusion: In the period 1988–2012, there was marked geographic and ethnic variation in childhood fracture incidence across the UK. These findings also implicate lifestyle and socio-economic differences associated with location and ethnicity, and are relevant to policy makers in the UK and internationally.
Text
Paediatric fracture CRPD geog ethnicity 12012016 R1 clean.docx
- Accepted Manuscript
Slideshow
Figure 1 - fracture by age and sex.pptx
- Other
Slideshow
Figure 2 - geography of paediatric fractures.pptx
- Other
More information
Accepted/In Press date: 18 January 2016
e-pub ahead of print date: 21 January 2016
Published date: April 2016
Keywords:
fracture, children, epidemiology, osteoporosis, ethnicity, cprd
Organisations:
MRC Life-Course Epidemiology Unit
Identifiers
Local EPrints ID: 386683
URI: http://eprints.soton.ac.uk/id/eprint/386683
ISSN: 8756-3282
PURE UUID: 5102e50e-5dba-45bc-ba2e-7a60e4840fa8
Catalogue record
Date deposited: 03 Feb 2016 14:00
Last modified: 18 Mar 2024 02:58
Export record
Altmetrics
Contributors
Author:
R.J. Moon
Author:
E.M. Curtis
Author:
F. de Vries
Author:
T. van Staa
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics
