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Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months

Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months
Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months
Summary - Background  Evidence that atopic eczema partly originates in utero is increasing, with some studies linking the risk of developing the condition with aspects of maternal diet during pregnancy. Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of some skin conditions including atopic eczema.
Objective To examine the relation of maternal serum concentrations of nicotinamide and related tryptophan metabolites to the risk of atopic eczema in the offspring.
Methods Within the UK Southampton Women Survey, infantile atopic eczema at ages 6 and 12 months was ascertained (modified UK Working Party Criteria for the Definition of Atopic Dermatitis). Maternal serum levels of kynurenine, kynurenic acid, anthranilic acid, tryptophan, nicotinamide and N1-methylnicotinamide were measured in late pregnancy by mass spectrometry (n = 497) and related to the odds ratio of infantile atopic eczema.
Results Maternal nicotinamide and related metabolite concentrations were not associated with offspring atopic eczema at age 6 months. Higher concentrations of nicotinamide and anthranilic acid were, however, associated with a lower risk of eczema at age 12 months (odds ratios 0.69, 95% CI 0.53–0.91/SD change, P = 0.007 and 0.63, 0.48–0.83, P = 0.001, respectively). The associations were robust to adjustment for potentially confounding variables.
Conclusion and clinical relevance This is the first study linking maternal serum concentrations of nicotinamide and related metabolites to the risk of atopic eczema in the offspring. The findings point to potentially modifiable maternal influences on this complex and highly prevalent condition
0954-7894
1337-1343
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Robinson, Sian
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

El-Heis, Sarah, Crozier, Sarah, Robinson, Sian, Harvey, Nicholas, Cooper, Cyrus, Inskip, Hazel and Godfrey, Keith (2016) Higher maternal serum concentrations of nicotinamide and related metabolites in late pregnancy are associated with a lower risk of offspring atopic eczema at age 12 months. Clinical & Experimental Allergy, 46 (10), 1337-1343. (doi:10.1111/cea.12782). (PMID:27517618)

Record type: Article

Abstract

Summary - Background  Evidence that atopic eczema partly originates in utero is increasing, with some studies linking the risk of developing the condition with aspects of maternal diet during pregnancy. Nicotinamide, a naturally occurring nutrient that is maintained through the dietary intakes of vitamin B3 and tryptophan, has been used in the treatment of some skin conditions including atopic eczema.
Objective To examine the relation of maternal serum concentrations of nicotinamide and related tryptophan metabolites to the risk of atopic eczema in the offspring.
Methods Within the UK Southampton Women Survey, infantile atopic eczema at ages 6 and 12 months was ascertained (modified UK Working Party Criteria for the Definition of Atopic Dermatitis). Maternal serum levels of kynurenine, kynurenic acid, anthranilic acid, tryptophan, nicotinamide and N1-methylnicotinamide were measured in late pregnancy by mass spectrometry (n = 497) and related to the odds ratio of infantile atopic eczema.
Results Maternal nicotinamide and related metabolite concentrations were not associated with offspring atopic eczema at age 6 months. Higher concentrations of nicotinamide and anthranilic acid were, however, associated with a lower risk of eczema at age 12 months (odds ratios 0.69, 95% CI 0.53–0.91/SD change, P = 0.007 and 0.63, 0.48–0.83, P = 0.001, respectively). The associations were robust to adjustment for potentially confounding variables.
Conclusion and clinical relevance This is the first study linking maternal serum concentrations of nicotinamide and related metabolites to the risk of atopic eczema in the offspring. The findings point to potentially modifiable maternal influences on this complex and highly prevalent condition

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More information

Accepted/In Press date: 1 August 2016
e-pub ahead of print date: 12 August 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 399567
URI: http://eprints.soton.ac.uk/id/eprint/399567
ISSN: 0954-7894
PURE UUID: a1ab0fb8-6e5c-4875-8042-6a84efdef068
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Sian Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 19 Aug 2016 12:58
Last modified: 18 Feb 2021 17:02

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Contributors

Author: Sarah El-Heis
Author: Sarah Crozier ORCID iD
Author: Sian Robinson ORCID iD
Author: Nicholas Harvey ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Hazel Inskip ORCID iD
Author: Keith Godfrey ORCID iD

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