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Faltering of prenatal growth precedes the development of atopic eczema in infancy:: cohort study

Faltering of prenatal growth precedes the development of atopic eczema in infancy:: cohort study
Faltering of prenatal growth precedes the development of atopic eczema in infancy:: cohort study
Background: infants with atopic eczema have an increased risk of impaired growth, but the origin of this impairment is unclear. The aim of this study was to examine fetal and infant growth in relation to infantile atopic eczema.

Methods: within the UK Southampton Women’s Survey, 1759 infants with known maternal menstrual data had anthropometric measurements at 11, 19, and 34 weeks’ gestation, birth and ages 6 and 12 months, enabling derivation of growth velocity standard deviation scores. Infantile atopic eczema at ages 6 and/or 12 months was ascertained using modified UK Working Party diagnostic criteria.

Results: expressed per SD increase, higher femur length and abdominal circumference at 34 weeks gestation were associated with decreased risks of atopic eczema (eczema OR /SD increase 0.81 (95%CI 0.69-0.96), p= 0.017; 0.78 (0.65-0.93), p=0.006, respectively), while, every SD increase in head to abdominal circumference ratio (indicating disproportionate growth) was associated with an increase in risk of atopic eczema (1.37(1.15-1.63), p= 0.001). . Lower velocities of linear growth from 11 weeks’ gestation to birth, and birth to age 6 months were associated with atopic eczema age 6 months (atopic eczema OR/SD increase 0.80, 0.65-0.98, p= 0.034; 0.81, 0.66-1.00, p= 0.051, respectively). Infants with atopic eczema age 12 months had a larger head circumference in early gestation and faltering of abdominal growth velocity from 19-34 weeks gestation (atopic eczema OR/SD increase 0.67 (0.51-0.88), p=0.003).

Conclusion: infants with atopic eczema demonstrate altered patterns of fetal growth, including faltering of linear growth in utero, prior to the clinical onset of atopic eczema. The findings suggest growth falters prior to the start of clinical atopic eczema and its treatment.
1179-1349
1851-1864
El-Heis, Sarah
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Crozier, Sarah R.
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Healy, Eugene
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Robinson, Sian M.
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Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
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Inskip, Hazel M.
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Baird, Janis
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Godfrey, Keith M.
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El-Heis, Sarah
6d7d2e03-3d63-4510-8b7e-fcbe4653db13
Crozier, Sarah R.
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Healy, Eugene
400fc04d-f81a-474a-ae25-7ff894be0ebd
Robinson, Sian M.
ba591c98-4380-456a-be8a-c452f992b69b
Harvey, Nicholas C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Inskip, Hazel M.
5fb4470a-9379-49b2-a533-9da8e61058b7
Baird, Janis
f4bf2039-6118-436f-ab69-df8b4d17f824
Godfrey, Keith M.
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd

El-Heis, Sarah, Crozier, Sarah R., Healy, Eugene, Robinson, Sian M., Harvey, Nicholas C., Cooper, Cyrus, Inskip, Hazel M., Baird, Janis and Godfrey, Keith M. (2018) Faltering of prenatal growth precedes the development of atopic eczema in infancy:: cohort study. Clinical Epidemiology, 10, 1851-1864. (doi:10.2147/CLEP.S175878).

Record type: Article

Abstract

Background: infants with atopic eczema have an increased risk of impaired growth, but the origin of this impairment is unclear. The aim of this study was to examine fetal and infant growth in relation to infantile atopic eczema.

Methods: within the UK Southampton Women’s Survey, 1759 infants with known maternal menstrual data had anthropometric measurements at 11, 19, and 34 weeks’ gestation, birth and ages 6 and 12 months, enabling derivation of growth velocity standard deviation scores. Infantile atopic eczema at ages 6 and/or 12 months was ascertained using modified UK Working Party diagnostic criteria.

Results: expressed per SD increase, higher femur length and abdominal circumference at 34 weeks gestation were associated with decreased risks of atopic eczema (eczema OR /SD increase 0.81 (95%CI 0.69-0.96), p= 0.017; 0.78 (0.65-0.93), p=0.006, respectively), while, every SD increase in head to abdominal circumference ratio (indicating disproportionate growth) was associated with an increase in risk of atopic eczema (1.37(1.15-1.63), p= 0.001). . Lower velocities of linear growth from 11 weeks’ gestation to birth, and birth to age 6 months were associated with atopic eczema age 6 months (atopic eczema OR/SD increase 0.80, 0.65-0.98, p= 0.034; 0.81, 0.66-1.00, p= 0.051, respectively). Infants with atopic eczema age 12 months had a larger head circumference in early gestation and faltering of abdominal growth velocity from 19-34 weeks gestation (atopic eczema OR/SD increase 0.67 (0.51-0.88), p=0.003).

Conclusion: infants with atopic eczema demonstrate altered patterns of fetal growth, including faltering of linear growth in utero, prior to the clinical onset of atopic eczema. The findings suggest growth falters prior to the start of clinical atopic eczema and its treatment.

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Clin Epi El-Heis et al Faltering of prenatal growth precedes the development of atopic eczema 220918 - Accepted Manuscript
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More information

Accepted/In Press date: 25 September 2018
e-pub ahead of print date: 12 December 2018
Published date: 12 December 2018

Identifiers

Local EPrints ID: 423696
URI: http://eprints.soton.ac.uk/id/eprint/423696
ISSN: 1179-1349
PURE UUID: 93905cce-259c-4e1e-91b7-a1c061e7fe83
ORCID for Sarah R. Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Sian M. Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Nicholas C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Hazel M. Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Janis Baird: ORCID iD orcid.org/0000-0002-4039-4361
ORCID for Keith M. Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 27 Sep 2018 16:30
Last modified: 26 Nov 2021 07:10

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Contributors

Author: Sarah El-Heis
Author: Eugene Healy
Author: Sian M. Robinson ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Hazel M. Inskip ORCID iD
Author: Janis Baird ORCID iD

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