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Prospective associations of maternal choline status with offspring body composition in the first five years of life in two larger mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort.

Prospective associations of maternal choline status with offspring body composition in the first five years of life in two larger mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort.
Prospective associations of maternal choline status with offspring body composition in the first five years of life in two larger mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort.
Background: Choline status has been positively associated with weight and fat mass in animal and human studies. As evidence examining maternal circulating choline concentrations and offspring body composition in human infants/children is lacking, we investigated this in two cohorts.
Methods: Maternal choline concentrations were measured in the UK Southampton Women’s Survey (SWS; serum, n=985, 11 weeks’ gestation) and Singapore Growing Up Towards healthy Outcomes (GUSTO); n=955, 26-28 weeks’ gestation) mother-offspring cohorts. Offspring anthropometry was measured at birth and age up to 5 years. Body fat mass was determined using DXA at birth and age 4 years for SWS, and using air displacement plethysmography at birth and age 5 years for GUSTO. Linear regression analyses were performed adjusting for confounders.
Results: In SWS, higher maternal choline concentrations were associated with higher neonatal total body fat mass [β=0.60 SD/5 µmol/L maternal choline (95% CI 0.04-1.16)] and higher subscapular skinfold thickness [β=0.55 mm/5 µmol/L (0.12-1.00)] at birth. In GUSTO, higher maternal choline concentrations were associated with higher neonatal BMI-for-age z-score [β=0.31 SD/5 µmol/L (0.10-0.51)], and higher triceps [β=0.38 mm/5 µmol/L (0.11-0.65)] and subscapular skinfold thicknesses [β=0.26 mm/5 µmol/L (0.01-0.50)] at birth. No consistent trends were observed between maternal choline and offspring gain in BMI, skinfold thicknesses, abdominal circumference, weight, length/height, and adiposity measures in later infancy and early childhood.
Conclusion: Our study provides evidence that maternal circulating choline concentrations during pregnancy are positively associated with offspring BMI, skinfold thicknesses and adiposity at birth, but not with growth and adiposity through infancy and early childhood to ages 5 years.
0300-5771
433-444
van Lee, Linda
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Crozier, Sarah
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Aris, Izzuddin M.
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Mya, Tint
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Sadananthan, Suresh
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Michael, Navin
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Quah, Phaik Ling
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Robinson, Sian M
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Inskip, Hazel
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Harvey, Nicholas
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Barker, Mary
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Cooper, Cyrus
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Velan, Sendhil
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Lee, Yung Seng
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Fortier, Marielle V.
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Yap, Fabian
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Gluckman, Peter D.
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Tan, Kok Hian
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Shek, Lynette Pei-Chi
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Chong, Yap-Seng
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Godfrey, Keith
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Chong, Mary F.F.
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van Lee, Linda
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Crozier, Sarah
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Aris, Izzuddin M.
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Mya, Tint
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Sadananthan, Suresh
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Michael, Navin
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Quah, Phaik Ling
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Robinson, Sian M
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Inskip, Hazel
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Harvey, Nicholas
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Barker, Mary
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Cooper, Cyrus
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Velan, Sendhil
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Lee, Yung Seng
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Fortier, Marielle V.
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Yap, Fabian
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Gluckman, Peter D.
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Tan, Kok Hian
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Shek, Lynette Pei-Chi
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Chong, Yap-Seng
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Godfrey, Keith
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Chong, Mary F.F.
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van Lee, Linda, Crozier, Sarah, Aris, Izzuddin M., Mya, Tint, Sadananthan, Suresh, Michael, Navin, Quah, Phaik Ling, Robinson, Sian M, Inskip, Hazel, Harvey, Nicholas, Barker, Mary, Cooper, Cyrus, Velan, Sendhil, Lee, Yung Seng, Fortier, Marielle V., Yap, Fabian, Gluckman, Peter D., Tan, Kok Hian, Shek, Lynette Pei-Chi, Chong, Yap-Seng, Godfrey, Keith and Chong, Mary F.F. (2019) Prospective associations of maternal choline status with offspring body composition in the first five years of life in two larger mother-offspring cohorts: the Southampton Women's Survey cohort and the Growing Up in Singapore Towards healthy Outcomes cohort. International Journal of Epidemiology, 48 (2), 433-444. (doi:10.1093/ije/dyy291).

Record type: Article

Abstract

Background: Choline status has been positively associated with weight and fat mass in animal and human studies. As evidence examining maternal circulating choline concentrations and offspring body composition in human infants/children is lacking, we investigated this in two cohorts.
Methods: Maternal choline concentrations were measured in the UK Southampton Women’s Survey (SWS; serum, n=985, 11 weeks’ gestation) and Singapore Growing Up Towards healthy Outcomes (GUSTO); n=955, 26-28 weeks’ gestation) mother-offspring cohorts. Offspring anthropometry was measured at birth and age up to 5 years. Body fat mass was determined using DXA at birth and age 4 years for SWS, and using air displacement plethysmography at birth and age 5 years for GUSTO. Linear regression analyses were performed adjusting for confounders.
Results: In SWS, higher maternal choline concentrations were associated with higher neonatal total body fat mass [β=0.60 SD/5 µmol/L maternal choline (95% CI 0.04-1.16)] and higher subscapular skinfold thickness [β=0.55 mm/5 µmol/L (0.12-1.00)] at birth. In GUSTO, higher maternal choline concentrations were associated with higher neonatal BMI-for-age z-score [β=0.31 SD/5 µmol/L (0.10-0.51)], and higher triceps [β=0.38 mm/5 µmol/L (0.11-0.65)] and subscapular skinfold thicknesses [β=0.26 mm/5 µmol/L (0.01-0.50)] at birth. No consistent trends were observed between maternal choline and offspring gain in BMI, skinfold thicknesses, abdominal circumference, weight, length/height, and adiposity measures in later infancy and early childhood.
Conclusion: Our study provides evidence that maternal circulating choline concentrations during pregnancy are positively associated with offspring BMI, skinfold thicknesses and adiposity at birth, but not with growth and adiposity through infancy and early childhood to ages 5 years.

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Accepted/In Press date: 20 December 2018
e-pub ahead of print date: 11 January 2019
Published date: April 2019

Identifiers

Local EPrints ID: 426873
URI: http://eprints.soton.ac.uk/id/eprint/426873
ISSN: 0300-5771
PURE UUID: af3377b2-7ddd-452f-98f9-5b4e991cb8d0
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Sian M Robinson: ORCID iD orcid.org/0000-0003-1766-7269
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Mary Barker: ORCID iD orcid.org/0000-0003-2976-0217
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 14 Dec 2018 17:30
Last modified: 10 Jan 2022 05:41

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Contributors

Author: Linda van Lee
Author: Sarah Crozier ORCID iD
Author: Izzuddin M. Aris
Author: Tint Mya
Author: Suresh Sadananthan
Author: Navin Michael
Author: Phaik Ling Quah
Author: Sian M Robinson ORCID iD
Author: Hazel Inskip ORCID iD
Author: Nicholas Harvey ORCID iD
Author: Mary Barker ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Sendhil Velan
Author: Yung Seng Lee
Author: Marielle V. Fortier
Author: Fabian Yap
Author: Peter D. Gluckman
Author: Kok Hian Tan
Author: Lynette Pei-Chi Shek
Author: Yap-Seng Chong
Author: Keith Godfrey ORCID iD
Author: Mary F.F. Chong

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