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Optical biosensors based on refractometric sensing schemes: A review

Optical biosensors based on refractometric sensing schemes: A review
Optical biosensors based on refractometric sensing schemes: A review

Biosensor technology is an active field of research and development presenting rapid progress in recent decades, and the subfield of optical biosensors based on refractometric sensing schemes has developed dramatically during this time. This review focuses on advances in the refractometric sensing-based guided-wave optical biosensors particularly in the last two decades. It starts with a concise discussion on the underlying principles of label-free refractometric biosensor. Subsequently, advances in biosensor design, especially the transducer configuration and the integration of the sensing device are reviewed, highlighting the challenges and efforts dedicated to improving this technology. Various surface functionalization strategies designed to produce well-defined and reproducible surface properties are introduced for evaluation. Refractometric sensing scheme-based optical biosensors have found versatile applications varying from environmental monitoring and food safety to clinical diagnostics, together with advances in these applications and others are described. This paper concludes with a brief discussion on the outlook for integrating biosensors with emerging technologies.

Applications, Guided-wave optical biosensor, Label-free biosensing, Refractive index
0956-5663
Chen, Yangyang
b0fb5b7b-25b8-48d6-8d24-5cf32a339ae0
Liu, Jinchuan
9fbe56b2-bfe5-4048-b62b-8a221a4e03fb
Yang, Zhenchuan
f2e74f2e-0e39-41b7-baf9-5acbfee16b29
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Zhou, Xiaohong
bb88cffe-e54d-4ff8-827a-1d549f8ab376
Chen, Yangyang
b0fb5b7b-25b8-48d6-8d24-5cf32a339ae0
Liu, Jinchuan
9fbe56b2-bfe5-4048-b62b-8a221a4e03fb
Yang, Zhenchuan
f2e74f2e-0e39-41b7-baf9-5acbfee16b29
Wilkinson, James S.
73483cf3-d9f2-4688-9b09-1c84257884ca
Zhou, Xiaohong
bb88cffe-e54d-4ff8-827a-1d549f8ab376

Chen, Yangyang, Liu, Jinchuan, Yang, Zhenchuan, Wilkinson, James S. and Zhou, Xiaohong (2019) Optical biosensors based on refractometric sensing schemes: A review. Biosensors and Bioelectronics, 144, [111693]. (doi:10.1016/j.bios.2019.111693).

Record type: Review

Abstract

Biosensor technology is an active field of research and development presenting rapid progress in recent decades, and the subfield of optical biosensors based on refractometric sensing schemes has developed dramatically during this time. This review focuses on advances in the refractometric sensing-based guided-wave optical biosensors particularly in the last two decades. It starts with a concise discussion on the underlying principles of label-free refractometric biosensor. Subsequently, advances in biosensor design, especially the transducer configuration and the integration of the sensing device are reviewed, highlighting the challenges and efforts dedicated to improving this technology. Various surface functionalization strategies designed to produce well-defined and reproducible surface properties are introduced for evaluation. Refractometric sensing scheme-based optical biosensors have found versatile applications varying from environmental monitoring and food safety to clinical diagnostics, together with advances in these applications and others are described. This paper concludes with a brief discussion on the outlook for integrating biosensors with emerging technologies.

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Optical biosensors based on refractometric sensing schemes_A review - Accepted Manuscript
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Supplementary Information_Optical biosensors based on refractometric sensing schemes - Other
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More information

Accepted/In Press date: 6 September 2019
e-pub ahead of print date: 11 September 2019
Published date: 1 November 2019
Keywords: Applications, Guided-wave optical biosensor, Label-free biosensing, Refractive index

Identifiers

Local EPrints ID: 434794
URI: http://eprints.soton.ac.uk/id/eprint/434794
ISSN: 0956-5663
PURE UUID: b738128e-cc95-44cb-9e3a-043a21db0354
ORCID for James S. Wilkinson: ORCID iD orcid.org/0000-0003-4712-1697

Catalogue record

Date deposited: 09 Oct 2019 16:30
Last modified: 07 Oct 2020 06:39

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Contributors

Author: Yangyang Chen
Author: Jinchuan Liu
Author: Zhenchuan Yang
Author: Xiaohong Zhou

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