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Association of asthma and smoking with lung function impairment in adolescence and early adulthood; the Isle of Wight Birth Cohort Study

Association of asthma and smoking with lung function impairment in adolescence and early adulthood; the Isle of Wight Birth Cohort Study
Association of asthma and smoking with lung function impairment in adolescence and early adulthood; the Isle of Wight Birth Cohort Study
We investigated associations of asthma and smoking with lung function and airway reversibility from childhood to early adulthood. The population-based Isle of Wight Birth Cohort (n=1456) was assessed at birth, 1, 2, 4, 10, 18 and 26-years. Asthma was defined as physician diagnosis plus current wheeze and/or treatment. Spirometry was conducted at 10 (n=981), 18 (n=839) and 26 years (n=547). Individuals were subdivided into: non-smokers without asthma, non-smokers with asthma, smokers without asthma, and smokers with asthma, based on asthma and smoking status at age 26. Their lung function trajectories from 10 to 26 years were examined using longitudinal models. Non-smokers with asthma had smaller FEV1, FEF25–75 and FEV1/FVC ratio compared to non-smokers without asthma at age 10 and 18, with differences reduced after bronchodilator (pre-bronchodilator FEV1 at 26-years: 3.75 L versus 4.02 L, p<0.001, post-bronchodilator 4.02 L versus 4.16 L, p=0.08). This lung function deficit did not worsen after 18-years. Smokers without asthma had smaller FEF25–75 and FEV1/FVC ratio (but not FEV1) at 26-years compared to non-smokers without asthma with the deficit appearing after 18 years and persisting despite bronchodilator response (for FEV1/FVC ratio at 26-years: 0.80 versus 0.81, p=0.002; post-bronchodilator 0.83 versus 0.85, p=0.005). Smokers with asthma had worst lung function compared to other groups. Lung function deficits associated with asthma and smoking occur early in life. They are not fully responsive to bronchodilator indicating a risk for long term lung health, which highlights the need to institute preventive measures in adolescence and early adult life before irreversible damage occurs.
0903-1936
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Hodgekiss, Claire
2acd047b-8a18-4a79-abba-126da1dbdd3d
Holloway, John
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Karmaus, Wilfreid
2a7c519b-60a6-4f5c-a221-9726f800cd02
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Arshad, S. Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Hodgekiss, Claire
2acd047b-8a18-4a79-abba-126da1dbdd3d
Holloway, John
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Karmaus, Wilfreid
2a7c519b-60a6-4f5c-a221-9726f800cd02
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3

Arshad, S. Hasan, Hodgekiss, Claire, Holloway, John, Kurukulaaratchy, Ramesh, Karmaus, Wilfreid, Zhang, Hongmei and Roberts, Graham (2019) Association of asthma and smoking with lung function impairment in adolescence and early adulthood; the Isle of Wight Birth Cohort Study. European Respiratory Journal. (doi:10.1183/13993003.00477-2019).

Record type: Article

Abstract

We investigated associations of asthma and smoking with lung function and airway reversibility from childhood to early adulthood. The population-based Isle of Wight Birth Cohort (n=1456) was assessed at birth, 1, 2, 4, 10, 18 and 26-years. Asthma was defined as physician diagnosis plus current wheeze and/or treatment. Spirometry was conducted at 10 (n=981), 18 (n=839) and 26 years (n=547). Individuals were subdivided into: non-smokers without asthma, non-smokers with asthma, smokers without asthma, and smokers with asthma, based on asthma and smoking status at age 26. Their lung function trajectories from 10 to 26 years were examined using longitudinal models. Non-smokers with asthma had smaller FEV1, FEF25–75 and FEV1/FVC ratio compared to non-smokers without asthma at age 10 and 18, with differences reduced after bronchodilator (pre-bronchodilator FEV1 at 26-years: 3.75 L versus 4.02 L, p<0.001, post-bronchodilator 4.02 L versus 4.16 L, p=0.08). This lung function deficit did not worsen after 18-years. Smokers without asthma had smaller FEF25–75 and FEV1/FVC ratio (but not FEV1) at 26-years compared to non-smokers without asthma with the deficit appearing after 18 years and persisting despite bronchodilator response (for FEV1/FVC ratio at 26-years: 0.80 versus 0.81, p=0.002; post-bronchodilator 0.83 versus 0.85, p=0.005). Smokers with asthma had worst lung function compared to other groups. Lung function deficits associated with asthma and smoking occur early in life. They are not fully responsive to bronchodilator indicating a risk for long term lung health, which highlights the need to institute preventive measures in adolescence and early adult life before irreversible damage occurs.

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More information

Accepted/In Press date: 22 November 2019
e-pub ahead of print date: 12 December 2019

Identifiers

Local EPrints ID: 436683
URI: http://eprints.soton.ac.uk/id/eprint/436683
ISSN: 0903-1936
PURE UUID: 74e67f59-a810-4fdb-92c9-595fa9014c03
ORCID for John Holloway: ORCID iD orcid.org/0000-0001-9998-0464
ORCID for Ramesh Kurukulaaratchy: ORCID iD orcid.org/0000-0002-1588-2400
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

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Date deposited: 20 Dec 2019 18:30
Last modified: 18 Feb 2021 17:04

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