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Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people

Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people
Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview of the commonly used pharmacological treatments for osteoporosis in older people.
Bone development, Older People, Osteoporosis, Osteosarcopenia, Pathophysiology, Treatment
1594-0667
759-773
Barnsley, J.
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Buckland, G.
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Chan, P.E.
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Ong, A.
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Ramos, A.S.
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Baxter, M.
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Laskou, F.
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Dennison, E.M.
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Cooper, C.
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Patel, H.P.
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Barnsley, J.
612cbba0-5384-4cec-9b3e-0f9189e84f64
Buckland, G.
3b86a553-c348-48d7-8f89-8e8052f58c30
Chan, P.E.
438e98a7-d8ae-458f-9fb4-4c93f4b40eba
Ong, A.
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Ramos, A.S.
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Baxter, M.
3415aa9a-8eb0-454e-9b7a-dadb1ce4e5c6
Laskou, F.
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Dennison, E.M.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Patel, H.P.
e1c0826f-d14e-49f3-8049-5b945d185523

Barnsley, J., Buckland, G., Chan, P.E., Ong, A., Ramos, A.S., Baxter, M., Laskou, F., Dennison, E.M., Cooper, C. and Patel, H.P. (2021) Pathophysiology and treatment of osteoporosis: challenges for clinical practice in older people. Aging Clinical and Experimental Research, 33 (4), 759-773. (doi:10.1007/s40520-021-01817-y).

Record type: Review

Abstract

Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview of the commonly used pharmacological treatments for osteoporosis in older people.

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Accepted/In Press date: 13 February 2021
e-pub ahead of print date: 20 March 2021
Published date: 20 March 2021
Additional Information: Funding Information: JB, GB, AO, PEC, ASR, MB and HPP are supported by the Department of Medicine for Older People, University Hospital Southampton, Southampton, UK. HPP and FL are supported by the NIHR Southampton Biomedical Research Centre, Nutrition and the University of Southampton. EMD and CC are supported by the MRC Lifecourse Epidemiology Centre. This report is independent research and the views expressed in this publication are those of the authors and not necessarily those of the NHS, the NIHR or the Department of Health. These funding bodies had no role in writing of the manuscript or decision to submit for publication. Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
Keywords: Bone development, Older People, Osteoporosis, Osteosarcopenia, Pathophysiology, Treatment
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Identifiers

Local EPrints ID: 448114
URI: http://eprints.soton.ac.uk/id/eprint/448114
DOI: doi:10.1007/s40520-021-01817-y
ISSN: 1594-0667
PURE UUID: ddcc0367-af40-4ba8-915f-f8aa6bafe127
ORCID for F. Laskou: ORCID iD orcid.org/0000-0002-8481-6343
ORCID for E.M. Dennison: ORCID iD orcid.org/0000-0002-3048-4961
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for H.P. Patel: ORCID iD orcid.org/0000-0002-0081-1802

Catalogue record

Date deposited: 01 Apr 2021 15:59
Last modified: 30 Nov 2024 02:43

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Contributors

Author: J. Barnsley
Author: G. Buckland
Author: P.E. Chan
Author: A. Ong
Author: A.S. Ramos
Author: M. Baxter
Author: F. Laskou ORCID iD
Author: E.M. Dennison ORCID iD
Author: C. Cooper ORCID iD
Author: H.P. Patel ORCID iD

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