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Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours

Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours
Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours
Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic ‘disinhibition’ phenotype. In a cohort of 117 subjects, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital, and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.
0007-1250
76-78
Chye, Yann
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Suo, Chao
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Romero-Garcia, Rafa
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Bethlehem, Richard
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Hook, Roxanne
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Tiego, Jeggan
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Goodyear, Ian
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Jones, Peter B
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Dolan, Ray
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Bullmore, Edward T
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Grant, Jon E
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Yucel, Murat
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Chamberlain, Samuel R.
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Chye, Yann
4d3c91bc-c9b5-43f0-a1fd-c50056d672f7
Suo, Chao
fb9c99cd-c388-4b99-974a-de4754e18cdc
Romero-Garcia, Rafa
c8441727-585a-4adf-b36c-7da0f8ef48cf
Bethlehem, Richard
6e3607aa-e770-447b-90e9-50c1abe2d36e
Hook, Roxanne
df1adf71-644e-413d-9b35-71264df83e0c
Tiego, Jeggan
ae9978d0-ca39-49db-a998-0421b8640f97
Goodyear, Ian
19f4c94c-7f02-4918-9e3a-1cbca13d477d
Jones, Peter B
8fb204a4-bd7f-4966-98e7-7b06a0af0958
Dolan, Ray
108b7c18-8d68-42d3-bba3-efb5e536ad02
Bullmore, Edward T
73492180-4e3f-4673-acf8-ad42ccc4e904
Grant, Jon E
07372bd5-8a0d-42b4-b41b-e376c652acf3
Yucel, Murat
3a9931b3-bc30-47ca-9646-6d6bbea3ec8b
Chamberlain, Samuel R.
8a0e09e6-f51f-4039-9287-88debe8d8b6f

Chye, Yann, Suo, Chao, Romero-Garcia, Rafa, Bethlehem, Richard, Hook, Roxanne, Tiego, Jeggan, Goodyear, Ian, Jones, Peter B, Dolan, Ray, Bullmore, Edward T, Grant, Jon E, Yucel, Murat and Chamberlain, Samuel R. (2021) Examining the relationship between altered brain functional connectome and disinhibition across 33 impulsive and compulsive behaviours. The British Journal of Psychiatry, 220 (2), 76-78. (doi:10.1192/bjp.2021.49).

Record type: Article

Abstract

Impulsive and compulsive problem behaviours are associated with a variety of mental disorders. Latent phenotyping indicates the expression of impulsive and compulsive problem behaviours is predominantly governed by a transdiagnostic ‘disinhibition’ phenotype. In a cohort of 117 subjects, recruited as part of the Neuroscience in Psychiatry Network (NSPN), we examined how brain functional connectome and network properties relate to disinhibition. Reduced functional connectivity within a subnetwork of frontal (especially right inferior frontal gyrus), occipital, and parietal regions was linked to disinhibition. Findings provide insights into neurobiological pathways underlying the emergence of impulsive and compulsive disorders.

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Accepted/In Press date: 28 March 2021
e-pub ahead of print date: 5 May 2021
Published date: 5 May 2021
Additional Information: This research was funded by a clinical fellowship from the Wellcome Trust to S.R.C. (reference 110049/Z/15/Z &/A). The study was supported by the Neuroscience in Psychiatry Network, a strategic award from the Wellcome Trust to the University of Cambridge and University College London (reference 095844/Z/11/Z); and by the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (Mental Health
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Identifiers

Local EPrints ID: 448297
URI: http://eprints.soton.ac.uk/id/eprint/448297
DOI: doi:10.1192/bjp.2021.49
ISSN: 0007-1250
PURE UUID: 0daf242f-eb56-445c-8de6-6e0f07c859c8
ORCID for Samuel R. Chamberlain: ORCID iD orcid.org/0000-0001-7014-8121

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Date deposited: 19 Apr 2021 16:31
Last modified: 30 Aug 2024 04:01

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Contributors

Author: Yann Chye
Author: Chao Suo
Author: Rafa Romero-Garcia
Author: Richard Bethlehem
Author: Roxanne Hook
Author: Jeggan Tiego
Author: Ian Goodyear
Author: Peter B Jones
Author: Ray Dolan
Author: Edward T Bullmore
Author: Jon E Grant
Author: Murat Yucel
Author: Samuel R. Chamberlain ORCID iD

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