Childhood food allergy and food allergen sensitisation are associated with adult airways disease: a birth cohort study
Childhood food allergy and food allergen sensitisation are associated with adult airways disease: a birth cohort study
Background: Childhood food allergy (FA) and food allergen sensitization (FAS) are associated with allergic airway disease(s) [AAD] (asthma and rhinitis) in childhood. However, the associations between childhood FA/FAS and AAD in adulthood are not well described. Methods: We investigated the longitudinal relationship between childhood FA/FAS to common food allergens and AAD at 18 and 26 years, in the Isle of Wight birth cohort. Study subjects (N = 1456) were followed up at fixed time points from ages 1–26 years for FA/FAS status. AAD were evaluated from 4 years onwards. The associations between FA/FAS and AAD were assessed with univariate analyses and then multivariable logistic regression, adjusting for clinically relevant co-variates. Results: Food allergy at 4 years was significantly associated with asthma at 18 years [adjusted odds ratio (aOR): 2.75, 95% CI: 1.53–4.92, p =.001] and 26 years (aOR: 2.62, 95% CI: 1.32–5.20, p =.006). Conversely, childhood FA was not associated with adulthood rhinitis whatsoever. While FAS at ages 4 and 10 were associated with both AAD, the associations between FAS and rhinitis were less robust relative to asthma. Conclusion: Childhood FA increased the odds of asthma during adulthood by nearly threefold. Additionally, childhood FAS was also associated with increased odds of asthma in adulthood. Conversely, FAS but not FA in childhood was associated with rhinitis in adulthood. We suggest that children with FA/FAS should be followed up to facilitate early detection and intervention of subsequent AAD, particularly asthma.
asthma, cohort studies, food hypersensitivity, longitudinal studies, respiratory hypersensitivity, rhinitis
1764-1772
Fong, Wei Chern Gavin
dde77f6c-3b15-4d09-aadd-89985eaa3491
Chan, Adrian
efaa9cf7-300c-4458-9d3d-45dc47ebbe85
Zhang, Hongmei
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Holloway, John W
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958
November 2021
Fong, Wei Chern Gavin
dde77f6c-3b15-4d09-aadd-89985eaa3491
Chan, Adrian
efaa9cf7-300c-4458-9d3d-45dc47ebbe85
Zhang, Hongmei
9f774048-54d6-4321-a252-3887b2c76db0
Holloway, John W
4bbd77e6-c095-445d-a36b-a50a72f6fe1a
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Kurukulaaratchy, Ramesh
9c7b8105-2892-49f2-8775-54d4961e3e74
Arshad, Syed Hasan
917e246d-2e60-472f-8d30-94b01ef28958
Fong, Wei Chern Gavin, Chan, Adrian, Zhang, Hongmei, Holloway, John W, Roberts, Graham, Kurukulaaratchy, Ramesh and Arshad, Syed Hasan
(2021)
Childhood food allergy and food allergen sensitisation are associated with adult airways disease: a birth cohort study.
Pediatric Allergy and Immunology, 32 (8), .
(doi:10.1111/pai.13592).
Abstract
Background: Childhood food allergy (FA) and food allergen sensitization (FAS) are associated with allergic airway disease(s) [AAD] (asthma and rhinitis) in childhood. However, the associations between childhood FA/FAS and AAD in adulthood are not well described. Methods: We investigated the longitudinal relationship between childhood FA/FAS to common food allergens and AAD at 18 and 26 years, in the Isle of Wight birth cohort. Study subjects (N = 1456) were followed up at fixed time points from ages 1–26 years for FA/FAS status. AAD were evaluated from 4 years onwards. The associations between FA/FAS and AAD were assessed with univariate analyses and then multivariable logistic regression, adjusting for clinically relevant co-variates. Results: Food allergy at 4 years was significantly associated with asthma at 18 years [adjusted odds ratio (aOR): 2.75, 95% CI: 1.53–4.92, p =.001] and 26 years (aOR: 2.62, 95% CI: 1.32–5.20, p =.006). Conversely, childhood FA was not associated with adulthood rhinitis whatsoever. While FAS at ages 4 and 10 were associated with both AAD, the associations between FAS and rhinitis were less robust relative to asthma. Conclusion: Childhood FA increased the odds of asthma during adulthood by nearly threefold. Additionally, childhood FAS was also associated with increased odds of asthma in adulthood. Conversely, FAS but not FA in childhood was associated with rhinitis in adulthood. We suggest that children with FA/FAS should be followed up to facilitate early detection and intervention of subsequent AAD, particularly asthma.
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Accepted/In Press date: 5 July 2021
e-pub ahead of print date: 9 July 2021
Published date: November 2021
Additional Information:
Funding Information:
This work was funded by the National Institutes of Health [grant numbers R01 AI061471, R01 HL082925, R01 AI091905 and R01 HL132321], Asthma UK for 10-year assessment (grant no. 364. PI: S.H. Arshad) and the David Hide Asthma and Allergy Research Trust for 26-year assessment (PI: S.H. Arshad). The funders did not contribute to study design, data collection, analysis, interpretation of data or in the preparation of the manuscript. The authors gratefully acknowledge the staff at the David Hide Asthma and Allergy Research Centre for performing assessments and data collection for the IOW birth cohort. We also thank the help of all study participants and their families of the IOW cohort. Finally, we would like to highlight the role of the late Dr. David Hide, who made this study possible.
Funding Information:
This work was funded by the National Institutes of Health [grant numbers R01 AI061471, R01 HL082925, R01 AI091905 and R01 HL132321], Asthma UK for 10‐year assessment (grant no. 364. PI: S.H. Arshad) and the David Hide Asthma and Allergy Research Trust for 26‐year assessment (PI: S.H. Arshad). The funders did not contribute to study design, data collection, analysis, interpretation of data or in the preparation of the manuscript.
Publisher Copyright:
© 2021 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.
Keywords:
asthma, cohort studies, food hypersensitivity, longitudinal studies, respiratory hypersensitivity, rhinitis
Identifiers
Local EPrints ID: 450907
URI: http://eprints.soton.ac.uk/id/eprint/450907
ISSN: 0905-6157
PURE UUID: 0f506057-1f77-4ff5-baea-42c9a46786d6
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Date deposited: 20 Aug 2021 16:30
Last modified: 17 Mar 2024 06:43
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Author:
Wei Chern Gavin Fong
Author:
Adrian Chan
Author:
Hongmei Zhang
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