The University of Southampton
University of Southampton Institutional Repository

High burden of respiratory allergy in children warrants early identification and treatment with allergen immunotherapy

High burden of respiratory allergy in children warrants early identification and treatment with allergen immunotherapy
High burden of respiratory allergy in children warrants early identification and treatment with allergen immunotherapy

Respiratory allergy often begins in childhood and most commonly manifests as allergic rhinitis (upper airways) and/or asthma (lower airways).) Children with upper respiratory allergy often suffer from coexisting asthma, and other comorbidities ranging from gastrointestinal disorders to emotional/mental health disorders. Consequently, the disease burden is considerable and profoundly impacts a child's daily life. Early identification and appropriate management are important to reduce disease burden, lower the risk of disease progression and additional comorbidities, and protect the child's future well-being. A window of opportunity for halting disease progression may open in the early stages of allergic disease and underlines the importance of early diagnosis and treatment of children at risk. This review offers advice on identifying children with a high disease burden who would benefit from early intervention. Allergen immunotherapy (AIT) modifies the cause of respiratory allergy and prevents disease progression. In clinical practice, AIT could be considered as an early treatment for eligible children, to achieve long-term symptom control and disease modification.

Allergy, Immunology, Paediatrics, Primary healthcare, Respiratory medicine, Therapeutics
0954-6111
Hamelmann, Eckard
9d833300-a54e-4424-859b-cec91fba97e5
Csonka, Péter
48f91e69-cb9a-4829-994c-2017b2fdd9d1
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Vogelberg, Christian
ebc4dc4c-ad5c-4b6f-9ab1-44bcbba7f71d
Cichocka-Jarosz, Ewa
a6f68812-548f-43cf-95c8-ece315847806
Just, Jocelyne
ae1fd282-3151-40c8-810b-5d57988e305b
Jeseňák, Miloš
b6059029-eef5-47ec-80b5-b3197de10c31
Hamelmann, Eckard
9d833300-a54e-4424-859b-cec91fba97e5
Csonka, Péter
48f91e69-cb9a-4829-994c-2017b2fdd9d1
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Vogelberg, Christian
ebc4dc4c-ad5c-4b6f-9ab1-44bcbba7f71d
Cichocka-Jarosz, Ewa
a6f68812-548f-43cf-95c8-ece315847806
Just, Jocelyne
ae1fd282-3151-40c8-810b-5d57988e305b
Jeseňák, Miloš
b6059029-eef5-47ec-80b5-b3197de10c31

Hamelmann, Eckard, Csonka, Péter, Roberts, Graham, Vogelberg, Christian, Cichocka-Jarosz, Ewa, Just, Jocelyne and Jeseňák, Miloš (2024) High burden of respiratory allergy in children warrants early identification and treatment with allergen immunotherapy. Respiratory Medicine, 234, [107812]. (doi:10.1016/j.rmed.2024.107812).

Record type: Article

Abstract

Respiratory allergy often begins in childhood and most commonly manifests as allergic rhinitis (upper airways) and/or asthma (lower airways).) Children with upper respiratory allergy often suffer from coexisting asthma, and other comorbidities ranging from gastrointestinal disorders to emotional/mental health disorders. Consequently, the disease burden is considerable and profoundly impacts a child's daily life. Early identification and appropriate management are important to reduce disease burden, lower the risk of disease progression and additional comorbidities, and protect the child's future well-being. A window of opportunity for halting disease progression may open in the early stages of allergic disease and underlines the importance of early diagnosis and treatment of children at risk. This review offers advice on identifying children with a high disease burden who would benefit from early intervention. Allergen immunotherapy (AIT) modifies the cause of respiratory allergy and prevents disease progression. In clinical practice, AIT could be considered as an early treatment for eligible children, to achieve long-term symptom control and disease modification.

Text
Hamelmann et al. manuscript 13-Sep-24 clean - Accepted Manuscript
Available under License Creative Commons Attribution.
Download (121kB)
Text
PIIS0954611124002877 - Version of Record
Available under License Creative Commons Attribution.
Download (3MB)
Text
Hamelmann et al. 2-Aug-23 - Other
Available under License Creative Commons Attribution.
Download (399kB)

More information

Accepted/In Press date: 19 September 2024
e-pub ahead of print date: 24 September 2024
Keywords: Allergy, Immunology, Paediatrics, Primary healthcare, Respiratory medicine, Therapeutics

Identifiers

Local EPrints ID: 496454
URI: http://eprints.soton.ac.uk/id/eprint/496454
ISSN: 0954-6111
PURE UUID: 64ac71fc-3f1c-44fa-b253-69ba5fa24366
ORCID for Graham Roberts: ORCID iD orcid.org/0000-0003-2252-1248

Catalogue record

Date deposited: 16 Dec 2024 17:32
Last modified: 17 Dec 2024 02:40

Export record

Altmetrics

Contributors

Author: Eckard Hamelmann
Author: Péter Csonka
Author: Graham Roberts ORCID iD
Author: Christian Vogelberg
Author: Ewa Cichocka-Jarosz
Author: Jocelyne Just
Author: Miloš Jeseňák

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×