Associations between skeletal muscle strength and chronic kidney disease in patients with MASLD
Associations between skeletal muscle strength and chronic kidney disease in patients with MASLD
Background: A skeletal muscle strength (SMS) decline is associated with metabolic diseases, but whether SMS also declines with chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is uncertain. This study examined the associations between SMS and the risk of CKD in MASLD population. Method: We performed a large-scale study with four cohorts: PERSONS and NHANES 2011–2014 cohorts for the cross-sectional investigation, and TCLSIH and UK Biobank cohorts for the longitudinal investigation. A handgrip dynamometer measured handgrip strength as a proxy for overall SMS. Participants were stratified according to CKD status [non-CKD vs. CKD (stages 1–5) groups]. Results: In the PERSONS cohort, the CKD group has a lower handgrip strength than the non-CKD group (27.14 ± 9.19 vs. 33.59 ± 11.92 kg, P < 0.001). Higher handgrip strength is associated with lower odds of abnormal albuminuria or CKD (OR: 0.96, 95%CI:0.92-0.99 and OR:0.95, 95%CI: 0.91-0.99 respectively). The highest handgrip strength tertile is associated with the lowest risk of having abnormal albuminuria or CKD (compared with the lowest or middle tertile). Results are similar in NHANES cohort. Furthermore, the highest handgrip strength is independently associated with the lowest risk of incident CKD in MASLD (HR: 0.95, 95%CI: 0.92-0.99 and HR:0.99, 95%CI: 0.98-0.99 in TCLSIH and UK Biobank cohorts). In Kaplan-Meier curve analysis, the cumulative incidence of CKD is lowest in the highest handgrip strength tertile compared to the lowest or the middle tertile. Conclusions: Higher handgrip/muscle strength is independently associated with a lower risk of CKD and abnormal albuminuria in MASLD population.
Zhang, Xin-Lei
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Gu, Yeqing
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Zhao, Jing
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Zhu, Pei-Wu
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Chen, Wen-Ying
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Li, Gang
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Liu, Wen-Yue
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Zheng, Wen
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Zhang, Ni
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Chen, Li-Li
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Targher, Giovanni
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Byrne, Christopher D.
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Niu, Kaijun
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Sun, Dan-Qin
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Zheng, Ming-Hua
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16 April 2025
Zhang, Xin-Lei
93ba6998-dfcc-485f-b0e8-497a60f489da
Gu, Yeqing
78c07c5d-c547-4771-8988-5ef9aae26865
Zhao, Jing
63b67512-a3f7-4a3e-9402-773bc0771f05
Zhu, Pei-Wu
dbeb95f5-b42b-4d3f-b61d-5e5d4fa6ce9e
Chen, Wen-Ying
f929aaa4-bec8-4acb-be17-67089efd0b63
Li, Gang
23622dc5-8a16-4900-b594-3145472baaf0
Liu, Wen-Yue
9e89b64b-acf2-4fef-a77c-2600b3484ede
Zheng, Wen
93888214-b3f7-46b2-82ea-40f3ef7148a6
Zhang, Ni
a9ff9ebe-a763-4532-9d8b-e6b0708d95c5
Chen, Li-Li
e1d4e6a0-fa4d-451f-82c6-f5ef0a83b882
Targher, Giovanni
fcb61590-29bf-44e6-8efe-fed0be4de30c
Byrne, Christopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Niu, Kaijun
61bcc038-6f85-475f-91ea-39df117c9017
Sun, Dan-Qin
e85ad26b-c94b-4388-a0eb-c21c1fc5d55f
Zheng, Ming-Hua
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Zhang, Xin-Lei, Gu, Yeqing, Zhao, Jing, Zhu, Pei-Wu, Chen, Wen-Ying, Li, Gang, Liu, Wen-Yue, Zheng, Wen, Zhang, Ni, Chen, Li-Li, Targher, Giovanni, Byrne, Christopher D., Niu, Kaijun, Sun, Dan-Qin and Zheng, Ming-Hua
(2025)
Associations between skeletal muscle strength and chronic kidney disease in patients with MASLD.
Communications Medicine, 5 (1), [118].
(doi:10.1038/s43856-025-00821-x).
Abstract
Background: A skeletal muscle strength (SMS) decline is associated with metabolic diseases, but whether SMS also declines with chronic kidney disease (CKD) in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) is uncertain. This study examined the associations between SMS and the risk of CKD in MASLD population. Method: We performed a large-scale study with four cohorts: PERSONS and NHANES 2011–2014 cohorts for the cross-sectional investigation, and TCLSIH and UK Biobank cohorts for the longitudinal investigation. A handgrip dynamometer measured handgrip strength as a proxy for overall SMS. Participants were stratified according to CKD status [non-CKD vs. CKD (stages 1–5) groups]. Results: In the PERSONS cohort, the CKD group has a lower handgrip strength than the non-CKD group (27.14 ± 9.19 vs. 33.59 ± 11.92 kg, P < 0.001). Higher handgrip strength is associated with lower odds of abnormal albuminuria or CKD (OR: 0.96, 95%CI:0.92-0.99 and OR:0.95, 95%CI: 0.91-0.99 respectively). The highest handgrip strength tertile is associated with the lowest risk of having abnormal albuminuria or CKD (compared with the lowest or middle tertile). Results are similar in NHANES cohort. Furthermore, the highest handgrip strength is independently associated with the lowest risk of incident CKD in MASLD (HR: 0.95, 95%CI: 0.92-0.99 and HR:0.99, 95%CI: 0.98-0.99 in TCLSIH and UK Biobank cohorts). In Kaplan-Meier curve analysis, the cumulative incidence of CKD is lowest in the highest handgrip strength tertile compared to the lowest or the middle tertile. Conclusions: Higher handgrip/muscle strength is independently associated with a lower risk of CKD and abnormal albuminuria in MASLD population.
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Accepted/In Press date: 24 March 2025
e-pub ahead of print date: 16 April 2025
Published date: 16 April 2025
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Local EPrints ID: 500574
URI: http://eprints.soton.ac.uk/id/eprint/500574
ISSN: 2730-664X
PURE UUID: 1a8896d2-5b54-4d1f-ba3c-f826e71fa9b0
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Date deposited: 06 May 2025 16:50
Last modified: 22 Aug 2025 01:45
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Author:
Xin-Lei Zhang
Author:
Yeqing Gu
Author:
Jing Zhao
Author:
Pei-Wu Zhu
Author:
Wen-Ying Chen
Author:
Gang Li
Author:
Wen-Yue Liu
Author:
Wen Zheng
Author:
Ni Zhang
Author:
Li-Li Chen
Author:
Giovanni Targher
Author:
Kaijun Niu
Author:
Dan-Qin Sun
Author:
Ming-Hua Zheng
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