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Placental size is associated differently with postnatal bone size and density

Placental size is associated differently with postnatal bone size and density
Placental size is associated differently with postnatal bone size and density
We investigated relationships between placental size and offspring adolescent bone indices using a population-based mother-offspring cohort. The Avon Longitudinal Study of Parents and Children (ALSPAC) recruited pregnant women from the South West of England between 1991 and 1993. 12,942 singleton babies were born at term and survived at least the first 12-months and from these, 8933 placentas were preserved in formaldehyde, with maternal permission for their use in research studies. At approximately 15.5 years the children underwent a DXA [Dual energy X-ray Absorptiometry) scan (measurements taken of whole body minus head bone area (BA), bone mineral content (BMC), and areal bone mineral density (aBMD)]. A pQCT (peripheral quantitative computed tomography) scan (Stratec XCT2000L) at the 50% tibial site was performed at this visit and at approximately 17.7 years. In 2010 a sample of 1,680 placentas were measured and photographed. To enable comparison of effect size across different variables, predictor and outcome variables were standardised to z-scores and therefore results may be interpreted as partial correlation coefficients. Complete placental, DXA and pQCT data were available for 518 children at 15.5 years. After adjustment for sex, gestational age at birth and age at time of pQCT, placental area was positively associated with endosteal circumference [? (95% CI): 0.21 (0.13, 0.30), p?<?0.001], periosteal circumference [? (95% CI): 0.19 (0.10, 0.27), p?<?0.001] and cortical area [? (95%CI): 0.10 (0.01, 0.18), p?=?0.03], and was negatively associated with cortical density [? (95%CI): -0.11 (-0.20, -0.03), p?=?0.01] at age 15.5 years. Similar relationships were observed for placental volume, and after adjustment for additional maternal and offspring covariates. These results suggest that previously observed associations between placental size and offspring bone development persist into older childhood, even during puberty, and that placental size is differentially related to bone size and volumetric density
epidemiology, osteoporosis, alspac, placenta, pqct, dxa, bones mass
0884-0431
1855-1864
Holroyd, C.R.
bd50c028-34f5-493c-86da-eeb5f7ea9e78
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Ring, S.
e19e1875-ffd0-4499-87f2-55ea20579115
Lawlor, D.A.
666139b1-03b8-4d92-bee7-98b5913fcb31
Tobias, J.H.
de2ae2cb-8547-475a-98e0-9d5169b8deb7
Davey Smith, G.
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Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145
Holroyd, C.R.
bd50c028-34f5-493c-86da-eeb5f7ea9e78
Osmond, C.
2677bf85-494f-4a78-adf8-580e1b8acb81
Barker, D.J.
cabc3433-b628-43e5-9fd7-e6ff5769bf44
Ring, S.
e19e1875-ffd0-4499-87f2-55ea20579115
Lawlor, D.A.
666139b1-03b8-4d92-bee7-98b5913fcb31
Tobias, J.H.
de2ae2cb-8547-475a-98e0-9d5169b8deb7
Davey Smith, G.
0de6af8f-976a-477d-a944-a98d0c8c1ebb
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Harvey, N.C.
ce487fb4-d360-4aac-9d17-9466d6cba145

Holroyd, C.R., Osmond, C., Barker, D.J., Ring, S., Lawlor, D.A., Tobias, J.H., Davey Smith, G., Cooper, C. and Harvey, N.C. (2016) Placental size is associated differently with postnatal bone size and density. Journal of Bone and Mineral Research, 31 (10), 1855-1864. (doi:10.1002/jbmr.2840). (PMID:26999363)

Record type: Article

Abstract

We investigated relationships between placental size and offspring adolescent bone indices using a population-based mother-offspring cohort. The Avon Longitudinal Study of Parents and Children (ALSPAC) recruited pregnant women from the South West of England between 1991 and 1993. 12,942 singleton babies were born at term and survived at least the first 12-months and from these, 8933 placentas were preserved in formaldehyde, with maternal permission for their use in research studies. At approximately 15.5 years the children underwent a DXA [Dual energy X-ray Absorptiometry) scan (measurements taken of whole body minus head bone area (BA), bone mineral content (BMC), and areal bone mineral density (aBMD)]. A pQCT (peripheral quantitative computed tomography) scan (Stratec XCT2000L) at the 50% tibial site was performed at this visit and at approximately 17.7 years. In 2010 a sample of 1,680 placentas were measured and photographed. To enable comparison of effect size across different variables, predictor and outcome variables were standardised to z-scores and therefore results may be interpreted as partial correlation coefficients. Complete placental, DXA and pQCT data were available for 518 children at 15.5 years. After adjustment for sex, gestational age at birth and age at time of pQCT, placental area was positively associated with endosteal circumference [? (95% CI): 0.21 (0.13, 0.30), p?<?0.001], periosteal circumference [? (95% CI): 0.19 (0.10, 0.27), p?<?0.001] and cortical area [? (95%CI): 0.10 (0.01, 0.18), p?=?0.03], and was negatively associated with cortical density [? (95%CI): -0.11 (-0.20, -0.03), p?=?0.01] at age 15.5 years. Similar relationships were observed for placental volume, and after adjustment for additional maternal and offspring covariates. These results suggest that previously observed associations between placental size and offspring bone development persist into older childhood, even during puberty, and that placental size is differentially related to bone size and volumetric density

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More information

Accepted/In Press date: 11 March 2016
e-pub ahead of print date: 21 March 2016
Published date: 1 October 2016
Keywords: epidemiology, osteoporosis, alspac, placenta, pqct, dxa, bones mass
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 390328
URI: http://eprints.soton.ac.uk/id/eprint/390328
ISSN: 0884-0431
PURE UUID: 9dbf94b7-86ed-4d7e-bcf7-5186541a93f2
ORCID for C. Osmond: ORCID iD orcid.org/0000-0002-9054-4655
ORCID for C. Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for N.C. Harvey: ORCID iD orcid.org/0000-0002-8194-2512

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Date deposited: 23 Mar 2016 16:36
Last modified: 18 Feb 2021 17:02

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Contributors

Author: C.R. Holroyd
Author: C. Osmond ORCID iD
Author: D.J. Barker
Author: S. Ring
Author: D.A. Lawlor
Author: J.H. Tobias
Author: G. Davey Smith
Author: C. Cooper ORCID iD
Author: N.C. Harvey ORCID iD

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