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Genetic variants linked to education predict longevity

Genetic variants linked to education predict longevity
Genetic variants linked to education predict longevity
Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ?17,000; UK Biobank, n = ?115,000; and the Estonian Biobank, n = ?6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ?2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ?2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.
0027-8424
13366-13371
Marioni, R.E.
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Ritchie, S.J.
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Joshi, P.K.
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Hagenaars, S.K.
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Okbay, A.
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Fischer, K.
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Adams, M.J.
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Hill, W.D.
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Davies, G.
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Nagy, R.
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Amador, C.
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Lall, K.
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Metspalu, A.
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Liewald, D.C.
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Campbell, A.
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Wilson, J.F.
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Hayward, C.
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Esko, T.
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Porteous, D.J.
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Gale, C.R.
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Deary, I.J.
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Marioni, R.E.
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Ritchie, S.J.
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Joshi, P.K.
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Hagenaars, S.K.
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Okbay, A.
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Fischer, K.
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Adams, M.J.
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Hill, W.D.
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Davies, G.
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Nagy, R.
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Amador, C.
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Lall, K.
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Metspalu, A.
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Liewald, D.C.
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Campbell, A.
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Wilson, J.F.
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Hayward, C.
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Esko, T.
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Porteous, D.J.
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Gale, C.R.
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Deary, I.J.
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Marioni, R.E., Ritchie, S.J., Joshi, P.K., Hagenaars, S.K., Okbay, A., Fischer, K., Adams, M.J., Hill, W.D., Davies, G., Nagy, R., Amador, C., Lall, K., Metspalu, A., Liewald, D.C., Campbell, A., Wilson, J.F., Hayward, C., Esko, T., Porteous, D.J., Gale, C.R. and Deary, I.J. (2016) Genetic variants linked to education predict longevity. Proceedings of the National Academy of Sciences, 113 (47), 13366-13371. (doi:10.1073/pnas.1605334113). (PMID:27799538)

Record type: Article

Abstract

Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ?17,000; UK Biobank, n = ?115,000; and the Estonian Biobank, n = ?6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using cohort members’ polygenic profile score for education to predict their parents’ longevity. Across the three cohorts, meta-analysis showed that a 1 SD higher polygenic education score was associated with ?2.7% lower mortality risk for both mothers (total ndeaths = 79,702) and ?2.4% lower risk for fathers (total ndeaths = 97,630). On average, the parents of offspring in the upper third of the polygenic score distribution lived 0.55 y longer compared with those of offspring in the lower third. Overall, these results indicate that the genetic contributions to educational attainment are useful in the prediction of human longevity.

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More information

Accepted/In Press date: 20 September 2016
e-pub ahead of print date: 22 November 2016
Additional Information: Social Science Genetic Association Consortium
Organisations: MRC Life-Course Epidemiology Unit

Identifiers

Local EPrints ID: 404610
URI: http://eprints.soton.ac.uk/id/eprint/404610
ISSN: 0027-8424
PURE UUID: 3b11e171-7c12-4116-a301-3b123a3ee834
ORCID for C.R. Gale: ORCID iD orcid.org/0000-0002-3361-8638

Catalogue record

Date deposited: 13 Jan 2017 13:52
Last modified: 16 Mar 2024 02:49

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Contributors

Author: R.E. Marioni
Author: S.J. Ritchie
Author: P.K. Joshi
Author: S.K. Hagenaars
Author: A. Okbay
Author: K. Fischer
Author: M.J. Adams
Author: W.D. Hill
Author: G. Davies
Author: R. Nagy
Author: C. Amador
Author: K. Lall
Author: A. Metspalu
Author: D.C. Liewald
Author: A. Campbell
Author: J.F. Wilson
Author: C. Hayward
Author: T. Esko
Author: D.J. Porteous
Author: C.R. Gale ORCID iD
Author: I.J. Deary

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