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Do components of adult height predict body composition and cardiometabolic risk in a young adult South Asian Indian population? Findings from a hospital-based cohort study in Pune, India: The PUNE Children's Study

Do components of adult height predict body composition and cardiometabolic risk in a young adult South Asian Indian population? Findings from a hospital-based cohort study in Pune, India: The PUNE Children's Study
Do components of adult height predict body composition and cardiometabolic risk in a young adult South Asian Indian population? Findings from a hospital-based cohort study in Pune, India: The PUNE Children's Study
Objectives: we investigated whether the relationship between components of height and CVD risk may be explained by body composition. We also examined relationships between parental heights and offspring CVD risk.

Design: a cohort study using cross-sectional data.

Setting: a secondary care hospital setting in Pune, India

Participants: we studied 357 young adults and their parents in the Pune Children’s Study. Primary and secondary outcomes: We measured weight, total height, leg length, sitting height, plasma glucose, insulin and lipids, and blood pressure. Total and regional lean and fat mass were measured by dual x-ray absorptiometry.

Results: leg length was inversely, and sitting height directly related to BMI. Total height and leg length were directly related to lean mass while sitting height was directly related to both lean and fat mass. Leg length was inversely related to systolic blood pressure and 120-minute glucose, independent of lean and fat mass. Sitting height was directly related to systolic blood pressure and triglycerides; these relationships were attenuated on adjustment for lean and fat mass. When examined simultaneously, greater leg length was protective and greater sitting height was associated with a more detrimental CVD risk profile.

Conclusions: shorter adult leg length and greater sitting height are associated with a more adverse CVD risk factor profile. The mechanisms need further study but our findings suggest a role for lean and fat mass.
2044-6055
Kumaran, Kalyanaraman
de6f872c-7339-4a52-be84-e3bbae707744
Joshi, S.M.
d479292a-5ad7-408d-bcaf-d1a5f2c829f9
Di Gravio, Chiara
4033fc31-5d17-4329-b741-aee8ba31d971
Lubree, Himangi
aa3fb2a8-81fb-4614-b136-3d04dfc3d85c
Joglekar, Charudutta
589c8367-aeb1-4858-9a2d-ee794c4463b0
Bhat, D.S.
75412cda-4b68-4286-82e2-8f9ea39fd842
Kinare, Arun S.
558ea0fd-7807-4c86-b6ab-d2465c24f8e4
Bavdekar, Ashish
6d4da828-7878-4dd0-b688-3726fd5bd12c
Bhave, Sheila A.
15b5d9ae-4a56-4d9a-a8fd-70353d8de978
Pandit, A.N.
425105e3-d008-4e1f-99d2-e1f4ef5bedaf
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Yajnik, Chittaranjan S.
f5777038-bba7-49bd-80b9-be4e586eecf4
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18
Kumaran, Kalyanaraman
de6f872c-7339-4a52-be84-e3bbae707744
Joshi, S.M.
d479292a-5ad7-408d-bcaf-d1a5f2c829f9
Di Gravio, Chiara
4033fc31-5d17-4329-b741-aee8ba31d971
Lubree, Himangi
aa3fb2a8-81fb-4614-b136-3d04dfc3d85c
Joglekar, Charudutta
589c8367-aeb1-4858-9a2d-ee794c4463b0
Bhat, D.S.
75412cda-4b68-4286-82e2-8f9ea39fd842
Kinare, Arun S.
558ea0fd-7807-4c86-b6ab-d2465c24f8e4
Bavdekar, Ashish
6d4da828-7878-4dd0-b688-3726fd5bd12c
Bhave, Sheila A.
15b5d9ae-4a56-4d9a-a8fd-70353d8de978
Pandit, A.N.
425105e3-d008-4e1f-99d2-e1f4ef5bedaf
Osmond, Clive
2677bf85-494f-4a78-adf8-580e1b8acb81
Yajnik, Chittaranjan S.
f5777038-bba7-49bd-80b9-be4e586eecf4
Fall, Caroline
7171a105-34f5-4131-89d7-1aa639893b18

Kumaran, Kalyanaraman, Joshi, S.M., Di Gravio, Chiara, Lubree, Himangi, Joglekar, Charudutta, Bhat, D.S., Kinare, Arun S., Bavdekar, Ashish, Bhave, Sheila A., Pandit, A.N., Osmond, Clive, Yajnik, Chittaranjan S. and Fall, Caroline (2020) Do components of adult height predict body composition and cardiometabolic risk in a young adult South Asian Indian population? Findings from a hospital-based cohort study in Pune, India: The PUNE Children's Study. BMJ Open. (In Press)

Record type: Article

Abstract

Objectives: we investigated whether the relationship between components of height and CVD risk may be explained by body composition. We also examined relationships between parental heights and offspring CVD risk.

Design: a cohort study using cross-sectional data.

Setting: a secondary care hospital setting in Pune, India

Participants: we studied 357 young adults and their parents in the Pune Children’s Study. Primary and secondary outcomes: We measured weight, total height, leg length, sitting height, plasma glucose, insulin and lipids, and blood pressure. Total and regional lean and fat mass were measured by dual x-ray absorptiometry.

Results: leg length was inversely, and sitting height directly related to BMI. Total height and leg length were directly related to lean mass while sitting height was directly related to both lean and fat mass. Leg length was inversely related to systolic blood pressure and 120-minute glucose, independent of lean and fat mass. Sitting height was directly related to systolic blood pressure and triglycerides; these relationships were attenuated on adjustment for lean and fat mass. When examined simultaneously, greater leg length was protective and greater sitting height was associated with a more detrimental CVD risk profile.

Conclusions: shorter adult leg length and greater sitting height are associated with a more adverse CVD risk factor profile. The mechanisms need further study but our findings suggest a role for lean and fat mass.

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Accepted/In Press date: 25 August 2020

Identifiers

Local EPrints ID: 443737
URI: http://eprints.soton.ac.uk/id/eprint/443737
ISSN: 2044-6055
PURE UUID: 3e8d1393-97b2-4bb1-8625-1692fd0d0d83
ORCID for Clive Osmond: ORCID iD orcid.org/0000-0002-9054-4655
ORCID for Caroline Fall: ORCID iD orcid.org/0000-0003-4402-5552

Catalogue record

Date deposited: 10 Sep 2020 16:46
Last modified: 17 Mar 2024 02:42

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Contributors

Author: S.M. Joshi
Author: Chiara Di Gravio
Author: Himangi Lubree
Author: Charudutta Joglekar
Author: D.S. Bhat
Author: Arun S. Kinare
Author: Ashish Bavdekar
Author: Sheila A. Bhave
Author: A.N. Pandit
Author: Clive Osmond ORCID iD
Author: Chittaranjan S. Yajnik
Author: Caroline Fall ORCID iD

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