Bioactive metabolites: a clue to the link between MASLD and CKD?
Bioactive metabolites: a clue to the link between MASLD and CKD?
Metabolites produced as intermediaries or end-products of microbial metabolism provide crucial signals for health and diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD). These metabolites include products of the bacterial metabolism of dietary substrates, modification of host molecules (such as bile acids [BAs], trimethylamine-N-oxide, and short-chain fatty acids), or products directly derived from bacteria. Recent studies have provided new insights into the association between MASLD and the risk of developing chronic kidney disease (CKD). Furthermore, alterations in microbiota composition and metabolite profiles, notably altered BAs, have been described in studies investigating the association between MASLD and the risk of CKD. This narrative review discusses alterations of specific classes of metabolites, BAs, fructose, vitamin D, and microbiota composition that may be implicated in the link between MASLD and CKD.
Bile acids, Bioactive metabolites, Chronic kidney disease, Gut microbiota, Metabolic dysfunction-associated steatotic liver disease
56-73
Chen, Wen-Ying
51152fbe-1ec6-48a6-b29b-83a76f5bd0ee
Zhang, Jia-Hui
89e44615-0ce5-471a-afb0-d1f2357c5e1b
Chen, Li-Li
8154c9b9-b607-42dd-be23-7233a1da5d69
Byrne, Chrisopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
fb906185-aa1c-4154-9b4c-b0cd0ece8e01
Luo, Liangjun
edc3d9e6-c39a-4f75-ae66-494cec9de7dc
Ni, Yan
8f051a88-3003-4949-b599-0aa184f965a7
Zheng, Ming-Hua
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Sun, Dan-Qin
a09afd7d-74e7-4f6f-a517-615fa908fab7
1 January 2025
Chen, Wen-Ying
51152fbe-1ec6-48a6-b29b-83a76f5bd0ee
Zhang, Jia-Hui
89e44615-0ce5-471a-afb0-d1f2357c5e1b
Chen, Li-Li
8154c9b9-b607-42dd-be23-7233a1da5d69
Byrne, Chrisopher D.
1370b997-cead-4229-83a7-53301ed2a43c
Targher, Giovanni
fb906185-aa1c-4154-9b4c-b0cd0ece8e01
Luo, Liangjun
edc3d9e6-c39a-4f75-ae66-494cec9de7dc
Ni, Yan
8f051a88-3003-4949-b599-0aa184f965a7
Zheng, Ming-Hua
3ef6b7f2-3a66-42d5-af48-1e0323f1f741
Sun, Dan-Qin
a09afd7d-74e7-4f6f-a517-615fa908fab7
Chen, Wen-Ying, Zhang, Jia-Hui, Chen, Li-Li, Byrne, Chrisopher D., Targher, Giovanni, Luo, Liangjun, Ni, Yan, Zheng, Ming-Hua and Sun, Dan-Qin
(2025)
Bioactive metabolites: a clue to the link between MASLD and CKD?
Clinical and Molecular Hepatology, 31 (1), .
(doi:10.3350/cmh.2024.0782).
Abstract
Metabolites produced as intermediaries or end-products of microbial metabolism provide crucial signals for health and diseases, such as metabolic dysfunction-associated steatotic liver disease (MASLD). These metabolites include products of the bacterial metabolism of dietary substrates, modification of host molecules (such as bile acids [BAs], trimethylamine-N-oxide, and short-chain fatty acids), or products directly derived from bacteria. Recent studies have provided new insights into the association between MASLD and the risk of developing chronic kidney disease (CKD). Furthermore, alterations in microbiota composition and metabolite profiles, notably altered BAs, have been described in studies investigating the association between MASLD and the risk of CKD. This narrative review discusses alterations of specific classes of metabolites, BAs, fructose, vitamin D, and microbiota composition that may be implicated in the link between MASLD and CKD.
Text
manuscript 202401008
- Accepted Manuscript
Text
Supplementary table 1
- Accepted Manuscript
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Supplementary table 2
- Accepted Manuscript
Text
cmh-2024-0782
- Version of Record
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Accepted/In Press date: 18 October 2024
e-pub ahead of print date: 21 October 2024
Published date: 1 January 2025
Keywords:
Bile acids, Bioactive metabolites, Chronic kidney disease, Gut microbiota, Metabolic dysfunction-associated steatotic liver disease
Identifiers
Local EPrints ID: 500559
URI: http://eprints.soton.ac.uk/id/eprint/500559
ISSN: 2287-2728
PURE UUID: 80a4192f-6c91-4982-8aa0-d90c2245fd31
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Date deposited: 06 May 2025 16:40
Last modified: 28 Aug 2025 01:39
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Contributors
Author:
Wen-Ying Chen
Author:
Jia-Hui Zhang
Author:
Li-Li Chen
Author:
Giovanni Targher
Author:
Liangjun Luo
Author:
Yan Ni
Author:
Ming-Hua Zheng
Author:
Dan-Qin Sun
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