A call for doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitis
A call for doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitis
Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly important contributor to morbidity and mortality. Little emphasis has been placed on its timely diagnosis and interventions to prevent adverse disease outcomes. The principal determinant of MASH outcomes is the liver fibrosis stage. The prevalence of MASH is higher among people living with obesity and/or type 2 diabetes, with MASH with moderate to advanced fibrosis affecting one in six adults. Delivering a paradigm shift in MASH diagnosis in the four countries studied will require an expansion of community-based diagnostic capability that will also foster prevention efforts and provide opportunities for treatment and care.
Diagnostic rate, Health policy, Health systems, MASH, MASLD, Public health
Lazarus, Jeffrey V.
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Brennan, Paul N.
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Mark, Henry E.
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Alazawi, William
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Allen, Alina M.
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Byrne, Christopher D.
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Castera, Laurent
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Caussy, Cyrielle
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Cusi, Kenneth
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Grajower, Martin M.
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Kopka, Christopher J.
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Massoels, Jo
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Roden, Michael
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Spearman, C. Wendy
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Tacke, Frank
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Wai-Sun Wong, Vincent
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Noureddin, Mazen
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1 July 2025
Lazarus, Jeffrey V.
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Brennan, Paul N.
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Mark, Henry E.
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Alazawi, William
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Allen, Alina M.
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Byrne, Christopher D.
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Castera, Laurent
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Caussy, Cyrielle
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Cusi, Kenneth
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Grajower, Martin M.
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Kopka, Christopher J.
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Massoels, Jo
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Roden, Michael
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Spearman, C. Wendy
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Tacke, Frank
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Wai-Sun Wong, Vincent
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Noureddin, Mazen
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Lazarus, Jeffrey V., Brennan, Paul N., Mark, Henry E., Alazawi, William, Allen, Alina M., Byrne, Christopher D., Castera, Laurent, Caussy, Cyrielle, Cusi, Kenneth, Grajower, Martin M., Kopka, Christopher J., Massoels, Jo, Roden, Michael, Spearman, C. Wendy, Tacke, Frank, Wai-Sun Wong, Vincent and Noureddin, Mazen
(2025)
A call for doubling the diagnostic rate of at-risk metabolic dysfunction-associated steatohepatitis.
The Lancet Regional Health – Europe, 54, [101320].
(doi:10.1016/j.lanepe.2025.101320).
Abstract
Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly important contributor to morbidity and mortality. Little emphasis has been placed on its timely diagnosis and interventions to prevent adverse disease outcomes. The principal determinant of MASH outcomes is the liver fibrosis stage. The prevalence of MASH is higher among people living with obesity and/or type 2 diabetes, with MASH with moderate to advanced fibrosis affecting one in six adults. Delivering a paradigm shift in MASH diagnosis in the four countries studied will require an expansion of community-based diagnostic capability that will also foster prevention efforts and provide opportunities for treatment and care.
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MASH Dx_ms_LRHE_18April2025_clean_FINAL
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MASH Dx_supp material_LRHE_14March2025_FINAL
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MASH Dx_table 1_LRHE_14March2025_FINAL
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Accepted/In Press date: 24 April 2025
e-pub ahead of print date: 4 June 2025
Published date: 1 July 2025
Additional Information:
© 2025 The Author(s).
Keywords:
Diagnostic rate, Health policy, Health systems, MASH, MASLD, Public health
Identifiers
Local EPrints ID: 501953
URI: http://eprints.soton.ac.uk/id/eprint/501953
ISSN: 2666-7762
PURE UUID: 7005816b-d33d-4c7c-ab4b-8b85f33e6995
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Date deposited: 12 Jun 2025 16:54
Last modified: 22 Aug 2025 01:45
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Contributors
Author:
Jeffrey V. Lazarus
Author:
Paul N. Brennan
Author:
Henry E. Mark
Author:
William Alazawi
Author:
Alina M. Allen
Author:
Laurent Castera
Author:
Cyrielle Caussy
Author:
Kenneth Cusi
Author:
Martin M. Grajower
Author:
Christopher J. Kopka
Author:
Jo Massoels
Author:
Michael Roden
Author:
C. Wendy Spearman
Author:
Frank Tacke
Author:
Vincent Wai-Sun Wong
Author:
Mazen Noureddin
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