IL-4 enhances expression and function of surface IgM in CLL cells -
Maria M. Aguilar-Hernandez,
Matthew Blunt,
Rachel Dobson,
Alison Yeomans,
Stephen Thirdborough,
Marta Larrayoz,
Lindsay Smith,
Adam Linley,
Jonathan C. Strefford,
Andrew Davies,
Peter Johnson,
Natalia Savelyeva,
Mark Cragg,
Francesco Forconi,
Graham Packham,
Freda K. Stevenson and
Andrew J. Steele
Type: Article
| 2016
Clinical importance of DNA methylation signatures in chronic lymphocytic leukaemia patients treated with chemo-immunotherapy -
Harindra Amarasinghe,
Tomasz K. Wojdacz,
Matthew John Jerome Rose-Zerilli,
Alice Beattie,
Jade Forster,
Latha Kadalayil,
Stuart Blakemore,
Helen Parker,
Marta Larrayoz,
Ruth Clifford,
Zadie Davis,
Monica Else,
Dena Cohen,
Andrew J. Steele,
Richard Rosenquist,
Andrew Collins,
Andrew Pettitt,
Peter Hillmen,
Pauline Robbe,
Christopher Plass,
Anna Schuh,
Daniel Catovsky,
David Oscier,
Christopher C. Oakes and
Jonathan C. Strefford
Type: Meeting abstract
| 2017
| Item not available on this server.
The contribution of gene mutations to long-term clinical outcomes: data from the randomised UK LRF CLL4 trial -
Stuart Blakemore,
Ruth Clifford,
Pavlos Antoniou,
Helen Parker,
Pauline Robbe,
Marta Larrayoz,
Zadie Davis,
Latha Kadalyayil,
Andrew Collins,
Jade Forster,
Monica Else,
Andrew J. Steele,
Jacqueline Chan,
Graham Speight,
Mark Cragg,
Matthew John Jerome Rose-Zerilli,
Daniel Catovsky,
David Oscier,
Anna Schuh and
Jonathan C. Strefford
Type: Meeting abstract
| 2017
| Item not available on this server.
The PI3K/mTOR inhibitor PF-04691502 induces apoptosis and inhibits microenvironmental signaling in CLL and the E?-TCL1 mouse model -
Matthew D. Blunt,
Matthew J. Carter,
Marta Larrayoz,
Lindsay D. Smith,
Maria Aguilar-Hernandez,
Kerry L. Cox,
Thomas R.W. Tipton,
Mark Reynolds,
Sarah Murphy,
Elizabeth Lemm,
Samantha Dias,
Andrew S. Duncombe,
Jonathan C. Strefford,
Peter W.M. Johnson,
Francesco Forconi,
Freda K. Stevenson,
Graham Packham,
Mark S. Cragg and
Andrew J. Steele
Type: Article
| 2015
The dual Syk/JAK inhibitor cerdulatinib antagonizes B-cell receptor and microenvironmental signaling in chronic lymphocytic leukemia -
Matthew D. Blunt,
Stefan Koehrer,
Rachel C. Dobson,
Marta Larrayoz,
Sarah Wilmore,
Alice Hayman,
Jack Parnell,
Lindsay D. Smith,
Andrew Davies,
Peter W.M. Johnson,
Pamela B. Conley,
Anjali Pandey,
Jonathan C. Strefford,
Freda K. Stevenson,
Graham Packham,
Francesco Forconi,
Greg P Coffey,
Jan A. Burger and
Andrew J. Steele
Type: Article
| 2017
Mycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology -
Patience T. Brace,
Liku B. Tezera,
Magdalena K. Bielecka,
Toby Mellows,
Diana Garay,
Shuye Tian,
Lucinda Rand,
Justin Green,
Sanjay Jogai,
Andrew J. Steele,
Timothy M. Millar,
Tilman Sanchez-Elsner,
Jon S. Friedland,
Christopher G. Proud and
Paul T. Elkington
Type: Article
| 2017
Type: Article
| 2013
| Item availability restricted.
Surface IgM expression and function associate with clinical behavior, genetic abnormalities and DNA methylation in CLL -
Annalisa D'Avola,
Samantha Drennan,
Ian Tracy,
Isla Henderson,
Laura Chiecchio,
Marta Larrayoz,
Matthew Rose-Zerilli,
Jonathan Strefford,
Christoph Plass,
Peter W. Johnson,
Andrew J. Steele,
Graham Packham,
Freda K. Stevenson,
Christopher C. Oakes and
Francesco Forconi
Type: Article
| 2016
STING activation reverses lymphoma-mediated resistance to antibody immunotherapy -
Lekh N Dahal,
Lang Dou,
Khiyam Hussain,
Rena Liu,
Alexander Earley,
Kerry L Cox,
Salome Murinello,
Ian Tracy,
Francesco Forconi,
Andrew J Steele,
Patrick Duriez,
Diego Gomez-Nicola,
Jessica L Teeling,
Martin J Glennie,
Mark S Cragg and
Stephen A Beers
Type: Article
| 2017
IL-10 production by CLL cells is enhanced in the anergic IGHV mutated subset and associates with reduced DNA methylation of the IL10 locus -
S. Drennan,
A. D'Avola,
Y. Gao,
C. Weigel,
E. Chrysostomou,
A.J. Steele,
T. Zenz,
C. Plass,
P.W. Johnson,
A.P. Williams,
G. Packham,
F.K. Stevenson,
C.C. Oakes and
F. Forconi
Type: Article
| 2017
Type: Article
| 2011
| Item not available on this server.
Tumour cells expressing single VEGF isoforms display distinct growth, survival and migration characteristics -
Chryso Kanthou,
Gabi U. Dachs,
Diane V. Lefley,
Andrew J. Steele,
Claudia Coralli-Foxon,
Sheila Harris,
Olga Greco,
Sofia A. Dos Santos,
Constantino C. Reyes-Aldasoro,
William R. English and
Gillian M. Tozer
Type: Article
| 2014
Stimulation of surface IgM of chronic lymphocytic leukemia cells induces an unfolded protein response dependent on BTK and SYK -
Sergey Krysov,
Andrew J. Steele,
Vania Coelho,
Adam Linley,
Marina Sanchez Hidalgo,
Matthew Carter,
Kathleen N. Potter,
Benjamin Kennedy,
Andrew S. Duncombe,
Margaret Ashton-Key,
Francesco Forconi,
Freda K. Stevenson and
Graham Packham
Type: Article
| 2014
The SF3B1 inhibitor spliceostatin A (SSA) elicits apoptosis in chronic lymphocytic leukemia cells through downregulation of Mcl-1 -
M. Larrayoz,
S.J. Blakemore,
R.C. Dobson,
M.D. Blunt,
M.J.J. Rose-Zerilli,
R. Walewska,
A. Duncombe,
D. Oscier,
K. Koide,
F. Forconi,
G. Packham,
M. Yoshida,
M.S. Cragg,
J.C. Strefford and
A.J. Steele
Type: Article
| 2015
Non-coding NOTCH1 mutations in chronic lymphocytic leukemia; their clinical impact in the UK CLL4 trial -
M. Larrayoz,
M.J.J. Rose-Zerilli,
L. Kadalayil,
H. Parker,
S. Blakemore,
J. Forster,
Z. Davis,
A.J. Steele,
A. Collins,
M. Else,
D. Catovsky,
D.G. Oscier and
J.C. Strefford
Type: Article
| 2017
Preclinical evaluation of a novel SHIP1 phosphatase activator for inhibition of PI3K signaling in malignant B-cells -
Elizabeth A. Lemm,
Beatriz Valle-Argos,
Lindsay D. Smith,
Johanna Richter,
Yohannes Gebreselassie,
Mathew J. Carter,
Jana Karolova,
Michael Svaton,
Karel Helman,
Nicola J. Weston-Bell,
Laura Karydis,
Chris T. Williamson,
Georg Lenz,
Jeremy Pettigrew,
Curtis Harwig,
Freda K. Stevenson,
Mark Cragg,
Francesco Forconi,
Andrew J. Steele,
Jennifer Cross,
Lloyd Mackenzie,
Pavel Klener and
Graham Packham
Type: Article
| 2019
Type: Dataset
| 2022
| University of Southampton
Genomic disruption of the histone methyltransferase SETD2 in chronic lymphocytic leukemia -
H. Parker,
M.J.J. Rose-Zerilli,
M. Larrayoz,
R. Clifford,
J. Edelmann,
S. Blakemore,
J. Gibson,
J. Wang,
V. Ljungström,
T.K. Wojdacz,
T. Chaplin,
A. Roghanian,
Z. Davis,
A. Parker,
E. Tausch,
S. Ntoufa,
S. Ramos,
P. Robbe,
R. Alsolami,
A.J. Steele,
G. Packham,
A.E. Rodriquez-Vicente,
L. Brown,
F. McNicholl,
F. Forconi,
A. Pettitt,
P. Hillmen,
M. Dyer,
M.S. Cragg,
C. Chelala,
C.C. Oakes,
R. Rosenquist,
K. Stamatopoulos,
S. Stilgenbauer,
S. Knight,
A. Schuh,
D.G. Oscier and
J.C. Strefford
Type: Article
| 2016
Differential cytopathology and kinetics of measles oncolysis in T=two primary B-cell malignancies provides mechanistic insights -
Bella Patel,
Aditi Dey,
Ehsan Ghorani,
Shaji Kumar,
Yogeshkumar Malam,
Lena Rai,
Andrew J. Steele,
Jennifer Thomson,
R. Gitendra Wickremasinghe,
Yu Zhang,
Anna Z. Castleton and
Adele K. Fielding
Type: Article
| 2011
| Item not available on this server.
Rewiring of sIgM-mediated intracellular signaling through the CD180 toll-like receptor -
Nino Porakishvili,
Ketki Vispute,
Andrew J. Steele,
Nadeeka Rajakaruna,
Nina Kulikova,
Tamar Tsertsvadze,
Amit Nathwani,
Rajendra N. Damle,
Edward A. Clark,
Kanti R. Rai,
Nicholas Chiorazzi and
Peter M. Lydyard
Type: Article
| 2015
Type: Book Section
| 2019
| Humana New York
| Item not available on this server.
Longitudinal copy number, whole exome and targeted deep
sequencing of 'good risk' IGHV-mutated CLL patients with
progressive disease -
Matthew Rose-Zerilli,
Jane Gibson,
Jun Wang,
Wi Tapper,
Zadie Davis,
Helen Parker,
Marta Larrayoz,
Helen McCarthy,
Renata Walewska,
Jade Forster,
Anne Gardiner,
Andrew Steele,
Claude Chelala,
Sarah Ennis,
Andrew Collins,
Christopher Oakes,
David Oscier and
Jonathan Strefford
Type: Article
| 2016
ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial -
Matthew J. Rose-Zerilli,
Jade Forster,
Helen Parker,
Anton Parker,
Ana E. Rodríguez,
Tracy Chaplin,
Anne Gardiner,
Andrew J. Steele,
A. Collins,
Bryan D. Young,
Anna Skowronska,
Daniel Catovsky,
Tanja Stankovic,
D.G. Oscier and
Jonathan C. Strefford
Type: Article
| 2014
| Item availability restricted.
Tracking subclonal mutations in IGHV-mutated CLL with progressive disease -
Matthew Jj Rose-Zerilli,
Gibson Jane,
Jun Wang,
William J. Tapper,
Helen Parker,
Anton Parker,
Zadie Davis,
Anne Catherine Gardiner,
Jade Forster,
Andrew J. Steele,
Renata Walewska,
Helen McCarthy,
Andrew Collins,
David G. Oscier and
Jonathan C. Strefford
Type: Meeting abstract
| 2014
| Item not available on this server.
BCR signaling contributes to autophagy regulation in chronic lymphocytic leukemia -
Lindsay Smith,
Annabel, Rachel Minton,
Matthew Blunt,
Laura Karydis,
David Dutton,
Karly-rai Rogers-broadway,
Rachel Dobson,
Rena Liu,
Faith Norster,
Elizabeth Hogg,
Margaret Ashton-Key,
Jonathan Strefford,
Li Jia,
Dimitar Efremov,
Helgason G. Vignir,
Peter Johnson,
Freda Stevenson,
Francesco Forconi,
Mark Cragg,
David Tumbarello,
Graham Packham and
Andrew Steele
Type: Article
| 2019
The sesquiterpene lactone parthenolide induces selective apoptosis of B-chronic lymphocytic leukemia cells in vitro. -
A.J. Steele,
D.T. Jones,
K. Ganeshaguru,
V.M. Duke,
B.C. Yogashangary,
J.M. North,
M.W. Lowdell,
P.D. Kottaridis,
A. Mehta,
A.G. Prentice,
A.V. Hoffbrand and
R.G. Wickremasinghe
Type: Article
| 2006
| Item not available on this server.
Type: Review
| 2018
| Item not available on this server.
Type: Article
| 2010
| Item not available on this server.
2-Phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells. -
Andrew J. Steele,
Archibald G. Prentice,
A. Victor Hoffbrand,
Birunthini C. Yogashangary,
Stephen M. Hart,
Mark W. Lowdell,
Edward R. Samuel,
Janet M. North,
Elisabeth P. Nacheva,
Anastasios Chanalaris,
Panagiotis Kottaridis,
Kate Cwynarski and
R. Gitendra Wickremasinghe
Type: Article
| 2009
| Item not available on this server.
p53-mediated apoptosis of CLL cells: evidence for a transcription-independent mechanism -
Andrew J. Steele,
Archibald G. Prentice,
A. Victor Hoffbrand,
Birunthini C. Yogashangary,
Stephen M. Hart,
Elisabeth P. Nacheva,
Julie D. Howard-Reeves,
Veronique M. Duke,
Panagiotis D. Kottaridis,
Kate Cwynarski,
Lyubomir T. Vassilev and
R. Gitendra. Wickremasinghe
Type: Article
| 2008
| Item not available on this server.
Type: Article
| 2011
| Item availability restricted.
Telomere length predicts progression and overall survival in chronic lymphocytic leukemia: data from the UK LRF CLL4 trial -
Jon Strefford,
Latha Kadalayil,
Jade forster,
Matthew Rose-Zerilli,
A. Parker,
T.T. Lin,
N. Heppel,
K. Norris,
A. Gardiner,
Z. Davies,
D. Gonzalez de Castro,
M. Else,
Andrew Steele,
Helen Parker,
T. Stankovic,
C. Pepper,
C. Fegan,
D. Baird,
Andrew Collins,
D. Catovsky and
David Oscier
Type: Article
| 2015
| Item availability restricted.
B-cell receptor signaling induces proteasomal degradation of PDCD4 via MEK1/2 and mTORC1 in malignant B cells -
Joe Taylor,
Sarah Wilmore,
Sophie Marriot,
Karly-Rai Rogers-Broadway,
Rachel Fell,
Annabel R. Minton,
Tom Branch,
Meg Ashton-Key,
Mark Coldwell,
Freda K. Stevenson,
Francesco Forconi,
Andrew J. Steele,
Graham Packham and
Alison Yeomans
Type: Article
| 2022
Type: Article
| 2011
| Item not available on this server.
Low frequency mutations independently predict poor treatment free survival in early stage chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis. -
Nils Winkelmann,
Matthew Rose-Zerilli,
Jade Forster,
Marina Parry,
Anton Parker,
Anne Gardiner,
Zadie Davis,
Andrew J Steele,
Helen Parker,
Nicholas C P Cross,
David G Oscier and
Jonathan C Strefford
Type: Article
| 2015
| Item not available on this server.
Clinical significance of DNA methylation in chronic lymphocytic leukaemia patients: results from three UK clinical trials -
Tomasz Wojdacz,
Harindra E. Amarasinghe,
Latha Kadalayil,
Alice Beattie,
Jade Forster,
Stuart Blakemore,
Helen Parker,
Dean Bryant,
Marta Larrayoz,
Ruth Clifford,
Pauline Robbe,
Zadie Davis,
Monica Else,
Dena R. Howard,
Basile Stamatopoulos,
Andrew Steele,
Richard Rosenquist,
Andrew Collins,
Andrew Pettitt,
Peter Hillmen,
Christoph Plass,
Anna Schuh,
Daniel Catovsky,
David G Oscier,
Matthew Rose-Zerilli,
Christopher C. Oakes and
Jonathan Strefford
Type: Article
| 2019
The clinical importance of DNA methylation signatures in chronic lymphocytic leukemia patients treated with chemo-immunotherapy -
Tomasz K. Wojdacz,
Harindra E. Amarasinghe,
Matthew J. J. Rose-Zerilli,
Alice Beattie,
Jade Forster,
Latha Kadalayil,
Stuart Blakemore,
Helen Parker,
Marta Larrayoz,
Ruth Clifford,
Zadie Davis,
Monica Else,
Dena Cohen,
Andrew J. Steele,
Richard Rosenquist,
Andrew Collins,
Andrew Pettitt,
Peter Hillmen,
Christoph Plass,
Anna Schuh,
Daniel Catovsky,
David G. Oscier,
Christopher C. Oakes and
Jonathan C. Strefford
Type: Meeting abstract
| 2018
| Item not available on this server.
PEITC-mediated inhibition of mRNA translation is associated with both inhibition of mTORC1 and increased eIF2alpha phosphorylation in established cell lines and primary human leukemia cells -
Alison Yeomans,
Elizabeth Lemm,
Sarah Wilmore,
Breeze Cavell,
Beatriz Valle-Argos,
Sergey Krysov,
Marina Hidalgo,
Elodie Leonard,
Anne E. Willis,
Francesco Forconi,
Freda Stevenson,
Andrew Steele,
Mark Coldwell and
Graham Packham
Type: Article
| 2016
Engagement of the B-cell receptor of chronic lymphocytic leukemia cells drives global and MYC-specific mRNA translation. -
Alison Yeomans,
Stephen M. Thirdborough,
Beatriz Valle-Argos,
Adam Linley,
Sergey Krysov,
Marina Sanchez Hidalgo,
Elodie Leonard,
Muhammad Ishfaq,
Simon D. Wagner,
Anne E. Willis,
Andrew Steele,
Freda Stevenson,
Francesco Forconi,
Mark J. Coldwell and
Graham Packham
Type: Article
| 2016
This list was generated on Mon Jan 19 04:33:37 2026 GMT.