High-resolution imaging of bone and joint architecture in rheumatoid arthritis
High-resolution imaging of bone and joint architecture in rheumatoid arthritis
INTRODUCTION: Rheumatoid arthritis (RA) is characterized by local and systemic bone loss caused by increased bone resorption. We describe the current utilization of high-resolution peripheral quantitative computed tomography (HR-pQCT) in the evaluation of bone and joint in RA.
SOURCES OF DATA: PubMed was searched for publications using keywords that included 'bone microarchitecture', 'high-resolution peripheral quantitative computed tomography' and 'rheumatoid arthritis'.
AREAS OF AGREEMENT: HR-pQCT may simultaneously allow assessment of trabecular and cortical bone parameters and be a useful method for depicting bone erosions.
AREAS OF CONTROVERSY: HR-pQCT only assesses bone microarchitecture at the distal radius and tibia. Controversy exists regarding the optimal way to differentiate cortical and trabecular regions.
GROWING POINTS: Although HR-pQCT is currently a research tool, there is potential for its use in the clinical diagnosis and management in RA. Further research is required to evaluate the clinical relevance of imaging abnormalities identified in RA patients.
rheumatoid arthritis, fracture, bone turnover markers, high-resolution peripheral quantitative computed tomography, volumetric bone mineral density, microarchitecture and bone erosions
107-118
Paccou, J.
1fea7730-cda7-4be3-a73e-a72e8ea09539
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Moss, C.
ae96895f-5c4a-49cd-a771-53bbd6f1d5fb
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
December 2014
Paccou, J.
1fea7730-cda7-4be3-a73e-a72e8ea09539
Edwards, M.H.
b81ff294-1d16-4a1b-af14-9374c5989d4c
Moss, C.
ae96895f-5c4a-49cd-a771-53bbd6f1d5fb
Dennison, E.M.
ee647287-edb4-4392-8361-e59fd505b1d1
Cooper, C.
e05f5612-b493-4273-9b71-9e0ce32bdad6
Paccou, J., Edwards, M.H., Moss, C., Dennison, E.M. and Cooper, C.
(2014)
High-resolution imaging of bone and joint architecture in rheumatoid arthritis.
British Medical Bulletin, 112 (1), .
(doi:10.1093/bmb/ldu033).
(PMID:25403741)
Abstract
INTRODUCTION: Rheumatoid arthritis (RA) is characterized by local and systemic bone loss caused by increased bone resorption. We describe the current utilization of high-resolution peripheral quantitative computed tomography (HR-pQCT) in the evaluation of bone and joint in RA.
SOURCES OF DATA: PubMed was searched for publications using keywords that included 'bone microarchitecture', 'high-resolution peripheral quantitative computed tomography' and 'rheumatoid arthritis'.
AREAS OF AGREEMENT: HR-pQCT may simultaneously allow assessment of trabecular and cortical bone parameters and be a useful method for depicting bone erosions.
AREAS OF CONTROVERSY: HR-pQCT only assesses bone microarchitecture at the distal radius and tibia. Controversy exists regarding the optimal way to differentiate cortical and trabecular regions.
GROWING POINTS: Although HR-pQCT is currently a research tool, there is potential for its use in the clinical diagnosis and management in RA. Further research is required to evaluate the clinical relevance of imaging abnormalities identified in RA patients.
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Accepted/In Press date: 10 October 2014
e-pub ahead of print date: 17 November 2014
Published date: December 2014
Keywords:
rheumatoid arthritis, fracture, bone turnover markers, high-resolution peripheral quantitative computed tomography, volumetric bone mineral density, microarchitecture and bone erosions
Organisations:
Human Development & Health
Identifiers
Local EPrints ID: 373791
URI: http://eprints.soton.ac.uk/id/eprint/373791
ISSN: 0007-1420
PURE UUID: aa5c2adf-72d3-443c-90da-31220c984c19
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Date deposited: 02 Feb 2015 14:28
Last modified: 18 Mar 2024 02:45
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Author:
J. Paccou
Author:
M.H. Edwards
Author:
C. Moss
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