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Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A population-based cohort study

Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A population-based cohort study
Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A population-based cohort study
Objective: Previous cohorts have reported associations between overweight/obesity and knee and hand osteoarthritis (OA). However, no data on the effect of these on the OA burden are available. We aimed to analyse the effect of overweight and obesity on the incidence of routinely diagnosed knee, hip, and hand OA.

Methods:

Design: population-based cohort

Setting: primary care records from the SIDIAP database (>5.5 million subjects) covering >80% of the population of Catalonia, Spain.

Participants: ?40 years old with no OA on 01/01/2006 and with body mass index (BMI) data available. Follow-up: from 01/01/2006 to 12/31/2010, loss to follow-up, or death.

Measures: BMI World Health Organization categories (exposure), and incident clinical diagnoses of knee, hip, or hand OA (ICD-10 codes).

Results: 1,764,061 subjects were observed for a median (inter-quartile range) of 4.45 (4.19 to 4.98) years. Incidence rates (per 1000 PY) of knee, hip and hand OA ranged from 3.7 (3.6 to 3.8), 1.7 (1.7 to 1.8) and 2.6 (2.5 to 2.7) amongst normal-weight, to 19.5 (19.1 to 19.9), 3.8 (3.7 to 4.0) and 4.0 (3.9 to 4.2) in the grade II obese respectively.

Compared to normal-weight subjects, being overweight or obese increased the risk of OA at all three sites, especially at the knee: overweight and (grade I, II) obesity increased knee OA risk by a factor of 2, 3.1 and 4.7 fold respectively.

Conclusions: Both overweight and obesity increase the risk of hand, hip, and knee OA, especially for the latter, with a dose-response gradient with increasing BMI.
0004-3591
1-28
Reyes, Carlen
1170cc74-1d60-44c6-a365-eca4c8b4b22e
Leyland, Kirsten M.
1fa50316-86aa-43f9-b37e-d9d0111de19c
Peat, George
e7056312-3bd0-430e-8ee7-f81f4c064c85
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, Nigel K.
23af958d-835c-4d79-be54-4bbe4c68077f
Prieto-Alhambra, Daniel
e596722a-2f01-4201-bd9d-be3e180e76a9
Reyes, Carlen
1170cc74-1d60-44c6-a365-eca4c8b4b22e
Leyland, Kirsten M.
1fa50316-86aa-43f9-b37e-d9d0111de19c
Peat, George
e7056312-3bd0-430e-8ee7-f81f4c064c85
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Arden, Nigel K.
23af958d-835c-4d79-be54-4bbe4c68077f
Prieto-Alhambra, Daniel
e596722a-2f01-4201-bd9d-be3e180e76a9

Reyes, Carlen, Leyland, Kirsten M., Peat, George, Cooper, Cyrus, Arden, Nigel K. and Prieto-Alhambra, Daniel (2016) Association between overweight and obesity and risk of clinically diagnosed knee, hip, and hand osteoarthritis: A population-based cohort study. Arthritis & Rheumatism, 1-28. (doi:10.1002/art.39707). (PMID:27059260)

Record type: Article

Abstract

Objective: Previous cohorts have reported associations between overweight/obesity and knee and hand osteoarthritis (OA). However, no data on the effect of these on the OA burden are available. We aimed to analyse the effect of overweight and obesity on the incidence of routinely diagnosed knee, hip, and hand OA.

Methods:

Design: population-based cohort

Setting: primary care records from the SIDIAP database (>5.5 million subjects) covering >80% of the population of Catalonia, Spain.

Participants: ?40 years old with no OA on 01/01/2006 and with body mass index (BMI) data available. Follow-up: from 01/01/2006 to 12/31/2010, loss to follow-up, or death.

Measures: BMI World Health Organization categories (exposure), and incident clinical diagnoses of knee, hip, or hand OA (ICD-10 codes).

Results: 1,764,061 subjects were observed for a median (inter-quartile range) of 4.45 (4.19 to 4.98) years. Incidence rates (per 1000 PY) of knee, hip and hand OA ranged from 3.7 (3.6 to 3.8), 1.7 (1.7 to 1.8) and 2.6 (2.5 to 2.7) amongst normal-weight, to 19.5 (19.1 to 19.9), 3.8 (3.7 to 4.0) and 4.0 (3.9 to 4.2) in the grade II obese respectively.

Compared to normal-weight subjects, being overweight or obese increased the risk of OA at all three sites, especially at the knee: overweight and (grade I, II) obesity increased knee OA risk by a factor of 2, 3.1 and 4.7 fold respectively.

Conclusions: Both overweight and obesity increase the risk of hand, hip, and knee OA, especially for the latter, with a dose-response gradient with increasing BMI.

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Accepted/In Press date: 29 March 2016
e-pub ahead of print date: 5 April 2016
Organisations: Faculty of Medicine

Identifiers

Local EPrints ID: 393106
URI: http://eprints.soton.ac.uk/id/eprint/393106
ISSN: 0004-3591
PURE UUID: debdd1cd-fc9c-47b9-97ea-1ec482a04116
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709

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Date deposited: 21 Apr 2016 08:45
Last modified: 17 Dec 2019 06:51

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Contributors

Author: Carlen Reyes
Author: Kirsten M. Leyland
Author: George Peat
Author: Cyrus Cooper ORCID iD
Author: Nigel K. Arden
Author: Daniel Prieto-Alhambra

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