Maternal body mass: relation with infant respiratory symptoms and infections
Maternal body mass: relation with infant respiratory symptoms and infections
Background Maternal obesity is increasingly prevalent in many westernised countries. Many studies report associations between maternal obesity and childhood wheeze or asthma but few have considered maternal obesity in relation to respiratory infections or symptoms other than wheeze during infancy. This study assesses the relationship between maternal BMI and reported wheeze, cough and respiratory infections during the first year of life.
Methods In 2799 mother-child pairs we examined the relations between maternal pre-pregnancy BMI and pregnancy weight gain and reported offspring wheeze, prolonged cough, lower respiratory tract infection, croup and ear infection before age one year, along with reported diarrhoea or vomiting. Maternally-reported paternal BMI was included in the models as a proxy for unmeasured confounding by shared familial factors.
Results Higher maternal BMI was associated with increased risks of offspring wheeze, prolonged cough and lower respiratory tract infection (relative risks (95% CI) per 5 kg m-2 1.09 (1.05-1.13), 1.09 (1.03-1.14) and 1.13 (1.07-1.20), respectively). These associations remained after adjusting for maternally-reported paternal BMI. No associations were found with croup, ear infection, or diarrhoea or vomiting. Pregnancy weight gain was not associated with any of the offspring symptoms or illnesses.
Discussion Higher maternal BMI is associated with increased risk of wheeze, cough and maternally reported lower respiratory tract infection in infancy. These associations were independent of maternally-reported paternal BMI. These observations might be explained by intrauterine effects of maternal obesity upon respiratory or immune development.
1291-1299
Rajappan, Ashley
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Pearce, Anna
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Inskip, Hazel
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Baird, Janis
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Crozier, Sarah
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Cooper, Cyrus
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Godfrey, Keith
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Roberts, Graham
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Lucas, Jane
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Pike, Katharine
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October 2017
Rajappan, Ashley
9c33fbbf-abfa-452a-8bca-2d5b210aa9db
Pearce, Anna
df369e6a-4a9a-41a0-a8fe-8d248d28c595
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Baird, Janis
f4bf2039-6118-436f-ab69-df8b4d17f824
Crozier, Sarah
9c3595ce-45b0-44fa-8c4c-4c555e628a03
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Roberts, Graham
ea00db4e-84e7-4b39-8273-9b71dbd7e2f3
Lucas, Jane
5cb3546c-87b2-4e59-af48-402076e25313
Pike, Katharine
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Rajappan, Ashley, Pearce, Anna, Inskip, Hazel, Baird, Janis, Crozier, Sarah, Cooper, Cyrus, Godfrey, Keith, Roberts, Graham, Lucas, Jane and Pike, Katharine
(2017)
Maternal body mass: relation with infant respiratory symptoms and infections.
Pediatric Pulmonology, 52 (10), .
(doi:10.1002/ppul.23779).
Abstract
Background Maternal obesity is increasingly prevalent in many westernised countries. Many studies report associations between maternal obesity and childhood wheeze or asthma but few have considered maternal obesity in relation to respiratory infections or symptoms other than wheeze during infancy. This study assesses the relationship between maternal BMI and reported wheeze, cough and respiratory infections during the first year of life.
Methods In 2799 mother-child pairs we examined the relations between maternal pre-pregnancy BMI and pregnancy weight gain and reported offspring wheeze, prolonged cough, lower respiratory tract infection, croup and ear infection before age one year, along with reported diarrhoea or vomiting. Maternally-reported paternal BMI was included in the models as a proxy for unmeasured confounding by shared familial factors.
Results Higher maternal BMI was associated with increased risks of offspring wheeze, prolonged cough and lower respiratory tract infection (relative risks (95% CI) per 5 kg m-2 1.09 (1.05-1.13), 1.09 (1.03-1.14) and 1.13 (1.07-1.20), respectively). These associations remained after adjusting for maternally-reported paternal BMI. No associations were found with croup, ear infection, or diarrhoea or vomiting. Pregnancy weight gain was not associated with any of the offspring symptoms or illnesses.
Discussion Higher maternal BMI is associated with increased risk of wheeze, cough and maternally reported lower respiratory tract infection in infancy. These associations were independent of maternally-reported paternal BMI. These observations might be explained by intrauterine effects of maternal obesity upon respiratory or immune development.
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Accepted/In Press date: 10 July 2017
e-pub ahead of print date: 16 August 2017
Published date: October 2017
Identifiers
Local EPrints ID: 412121
URI: http://eprints.soton.ac.uk/id/eprint/412121
ISSN: 8755-6863
PURE UUID: 46ff4149-556a-4e8d-b71f-3233f7d2c52a
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Date deposited: 11 Jul 2017 16:31
Last modified: 18 Mar 2024 05:08
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Author:
Ashley Rajappan
Author:
Anna Pearce
Author:
Katharine Pike
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