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Maternal body mass: relation with infant respiratory symptoms and infections

Maternal body mass: relation with infant respiratory symptoms and infections
Maternal body mass: relation with infant respiratory symptoms and infections
Background Maternal obesity is increasingly prevalent in many westernised countries. Many studies report associations between maternal obesity and childhood wheeze or asthma but few have considered maternal obesity in relation to respiratory infections or symptoms other than wheeze during infancy. This study assesses the relationship between maternal BMI and reported wheeze, cough and respiratory infections during the first year of life.

Methods In 2799 mother-child pairs we examined the relations between maternal pre-pregnancy BMI and pregnancy weight gain and reported offspring wheeze, prolonged cough, lower respiratory tract infection, croup and ear infection before age one year, along with reported diarrhoea or vomiting. Maternally-reported paternal BMI was included in the models as a proxy for unmeasured confounding by shared familial factors.

Results Higher maternal BMI was associated with increased risks of offspring wheeze, prolonged cough and lower respiratory tract infection (relative risks (95% CI) per 5 kg m-2 1.09 (1.05-1.13), 1.09 (1.03-1.14) and 1.13 (1.07-1.20), respectively). These associations remained after adjusting for maternally-reported paternal BMI. No associations were found with croup, ear infection, or diarrhoea or vomiting. Pregnancy weight gain was not associated with any of the offspring symptoms or illnesses.

Discussion Higher maternal BMI is associated with increased risk of wheeze, cough and maternally reported lower respiratory tract infection in infancy. These associations were independent of maternally-reported paternal BMI. These observations might be explained by intrauterine effects of maternal obesity upon respiratory or immune development.
8755-6863
1291-1299
Rajappan, Ashley
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Pearce, Anna
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Inskip, Hazel
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Baird, Janis
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Crozier, Sarah
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Cooper, Cyrus
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Godfrey, Keith
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Roberts, Graham
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Lucas, Jane
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Pike, Katharine
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Rajappan, Ashley
9c33fbbf-abfa-452a-8bca-2d5b210aa9db
Pearce, Anna
df369e6a-4a9a-41a0-a8fe-8d248d28c595
Inskip, Hazel
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Baird, Janis
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Crozier, Sarah
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Cooper, Cyrus
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Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Roberts, Graham
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Lucas, Jane
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Pike, Katharine
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Rajappan, Ashley, Pearce, Anna, Inskip, Hazel, Baird, Janis, Crozier, Sarah, Cooper, Cyrus, Godfrey, Keith, Roberts, Graham, Lucas, Jane and Pike, Katharine (2017) Maternal body mass: relation with infant respiratory symptoms and infections. Pediatric Pulmonology, 52 (10), 1291-1299. (doi:10.1002/ppul.23779).

Record type: Article

Abstract

Background Maternal obesity is increasingly prevalent in many westernised countries. Many studies report associations between maternal obesity and childhood wheeze or asthma but few have considered maternal obesity in relation to respiratory infections or symptoms other than wheeze during infancy. This study assesses the relationship between maternal BMI and reported wheeze, cough and respiratory infections during the first year of life.

Methods In 2799 mother-child pairs we examined the relations between maternal pre-pregnancy BMI and pregnancy weight gain and reported offspring wheeze, prolonged cough, lower respiratory tract infection, croup and ear infection before age one year, along with reported diarrhoea or vomiting. Maternally-reported paternal BMI was included in the models as a proxy for unmeasured confounding by shared familial factors.

Results Higher maternal BMI was associated with increased risks of offspring wheeze, prolonged cough and lower respiratory tract infection (relative risks (95% CI) per 5 kg m-2 1.09 (1.05-1.13), 1.09 (1.03-1.14) and 1.13 (1.07-1.20), respectively). These associations remained after adjusting for maternally-reported paternal BMI. No associations were found with croup, ear infection, or diarrhoea or vomiting. Pregnancy weight gain was not associated with any of the offspring symptoms or illnesses.

Discussion Higher maternal BMI is associated with increased risk of wheeze, cough and maternally reported lower respiratory tract infection in infancy. These associations were independent of maternally-reported paternal BMI. These observations might be explained by intrauterine effects of maternal obesity upon respiratory or immune development.

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Accepted/In Press date: 10 July 2017
e-pub ahead of print date: 16 August 2017
Published date: October 2017

Identifiers

Local EPrints ID: 412121
URI: https://eprints.soton.ac.uk/id/eprint/412121
ISSN: 8755-6863
PURE UUID: 46ff4149-556a-4e8d-b71f-3233f7d2c52a
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Janis Baird: ORCID iD orcid.org/0000-0002-4039-4361
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 11 Jul 2017 16:31
Last modified: 10 Dec 2019 05:56

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Contributors

Author: Ashley Rajappan
Author: Anna Pearce
Author: Hazel Inskip ORCID iD
Author: Janis Baird ORCID iD
Author: Sarah Crozier ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Keith Godfrey ORCID iD
Author: Graham Roberts
Author: Jane Lucas
Author: Katharine Pike

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