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Cardiovascular magnetic resonance imaging in the UK Biobank: a major international health research resource

Cardiovascular magnetic resonance imaging in the UK Biobank: a major international health research resource
Cardiovascular magnetic resonance imaging in the UK Biobank: a major international health research resource
The UK Biobank (UKB) is a health research resource of major international importance, incorporating comprehensive characterisation of over 500,000 men and women recruited between 2006-2010 from across the UK. There is prospective tracking of health outcomes for all participants through linkages with national cohorts (death registers, cancer registers, electronic hospital records, primary care records). The dataset has been enhanced with the UKB imaging study, which aims to scan a subset of 100,000 participants. The imaging protocol includes magnetic resonance imaging of the brain, heart, and abdomen, carotid ultrasound, and whole-body dual x-ray absorptiometry (DXA). Since its launch in 2015, over 48,000 participants have completed the imaging study with scheduled completion in 2023. Repeat imaging of 10,000 participants has been approved and commenced in 2019. The cardiovascular magnetic resonance (CMR) scan provides detailed assessment of cardiac structure and function comprising bright blood anatomic assessment (sagittal, coronal, axial), left and right ventricular cine images (long and short axis), myocardial tagging, native T1 mapping, aortic flow, and imaging of the thoracic aorta. The UKB is an open access resource available to health researchers across all scientific disciplines from both academia and industry with no preferential access or exclusivity. In this paper, we consider how we may best utilise the UKB CMR data to advance cardiovascular research and review notable achievements to date.
0195-668X
Raisi-Estabragh, Zahra
43c85c5e-4574-476b-80d6-8fb1cdb3df0a
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Neubauer, Stefan
c8a34156-a4ed-4dfe-97cb-4f47627d927d
Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928
Raisi-Estabragh, Zahra
43c85c5e-4574-476b-80d6-8fb1cdb3df0a
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Neubauer, Stefan
c8a34156-a4ed-4dfe-97cb-4f47627d927d
Petersen, Steffen E.
04f2ce88-790d-48dc-baac-cbe0946dd928

Raisi-Estabragh, Zahra, Harvey, Nicholas, Neubauer, Stefan and Petersen, Steffen E. (2020) Cardiovascular magnetic resonance imaging in the UK Biobank: a major international health research resource. European Heart Journal. (In Press)

Record type: Article

Abstract

The UK Biobank (UKB) is a health research resource of major international importance, incorporating comprehensive characterisation of over 500,000 men and women recruited between 2006-2010 from across the UK. There is prospective tracking of health outcomes for all participants through linkages with national cohorts (death registers, cancer registers, electronic hospital records, primary care records). The dataset has been enhanced with the UKB imaging study, which aims to scan a subset of 100,000 participants. The imaging protocol includes magnetic resonance imaging of the brain, heart, and abdomen, carotid ultrasound, and whole-body dual x-ray absorptiometry (DXA). Since its launch in 2015, over 48,000 participants have completed the imaging study with scheduled completion in 2023. Repeat imaging of 10,000 participants has been approved and commenced in 2019. The cardiovascular magnetic resonance (CMR) scan provides detailed assessment of cardiac structure and function comprising bright blood anatomic assessment (sagittal, coronal, axial), left and right ventricular cine images (long and short axis), myocardial tagging, native T1 mapping, aortic flow, and imaging of the thoracic aorta. The UKB is an open access resource available to health researchers across all scientific disciplines from both academia and industry with no preferential access or exclusivity. In this paper, we consider how we may best utilise the UKB CMR data to advance cardiovascular research and review notable achievements to date.

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Accepted/In Press date: 7 October 2020

Identifiers

Local EPrints ID: 444372
URI: http://eprints.soton.ac.uk/id/eprint/444372
ISSN: 0195-668X
PURE UUID: c868c57c-58f0-4244-bcec-e50add075072
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512

Catalogue record

Date deposited: 14 Oct 2020 16:31
Last modified: 09 Oct 2021 04:01

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Contributors

Author: Zahra Raisi-Estabragh
Author: Nicholas Harvey ORCID iD
Author: Stefan Neubauer
Author: Steffen E. Petersen

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