Items where Division is "Current Faculties > Faculty of Medicine > Cancer Sciences > Southampton Clinical Trials Unit
Cancer Sciences > Southampton Clinical Trials Unit" and Year is 2022
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Number of items: 59.
Article
DEPEND study protocol: early detection of patients with pancreatic cancer - a pilot study to evaluate the utility of faecal elastase-1 and 13C-mixed triglyceride breath test as screening tools in high-risk individuals - Paul Remi Afolabi, Declan McDonnell, Christopher D Byrne, Sam Wilding, Victoria Goss, Jocelyn Walters and Zaed Z Hamady
Type: Article
| 2022
Studies within a trial priorities to improve the evidence to inform recruitment and retention practice in clinical trials - Cherish Boxall, Shaun Treweek and Katie Gillies
Type: Article
| 2022
SCOPE 2 – still answering the unanswered questions in oesophageal radiotherapy? SCOPE 2: a randomised phase II/III trial to study radiotherapy dose escalation in patients with oesophageal cancer treated with definitive chemoradiation with an embedded phase II trial for patients with a poor early response using positron emission tomography/computed tomography - S. Bridges, B. Thomas, G. Radhakrishna, M. Hawkins, A. Holborow, C. Hurt, S. Mukherjee, L. Nixon, T. Crosby and S. Gwynne
Type: Article
| 2022
| Item not available on this server.
A road map for designing phase I clinical trials of radiotherapy–novel agent combinations - Sarah R. Brown, Samantha Hinsley and Emma Hall
Type: Article
| 2022
Type: Article
| 2022
| Item not available on this server.
Cluster randomised controlled trial to assess a tailored intervention to reduce antibiotic prescribing in rural China: study protocol - Wenjuan Cong, Jing Chai, Linhai Zhao, Christie Cabral, Lucy Yardley, Guiqing Lily Yao, Tingting Zhang, Jing Cheng, XingRong Shen, Rong Liu, Paul Little, Beth Stuart, Xiaowen Hu, Ye-Huan Sun, Isabel Oliver, Bo Zheng, Helen Lambert and DeBin Wang
Type: Article
| 2022
Overall survival update for patients with metastatic castration-resistant prostate cancer treated with Capivasertib and docetaxel in the Phase 2 ProCAID clinical trial - Simon J Crabb, Gareth Griffiths, Denise Dunkley, Nichola Downs, Mary Ellis, Mike Radford, Michelle Light, Josh Northey, Amy Whitehead, Sam Wilding, Alison J Birtle, Vincent Khoo and Robert J Jones
Type: Article
| 2022
Quality of life and health status in older adults (≥65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study - Amanda Cummings, Rebecca Foster, Lynn Calman, Natalia V. Permyakova, Jackie Bridges, Theresa Wiseman, Teresa Corbett, Peter W. F. Smith and Claire Foster
Type: Article
| 2022
ACCEPT - combining acalabrutinib with rituximab, cyclophosphamide, doxorubicin, vincristine and prednisolone (R-CHOP) for Diffuse Large B-cell Lymphoma (DLBCL): study protocol for a Phase Ib/II open-label non-randomised clinical trial - Andrew Davies, Sharon Barrans, Cathy Burton, Katy Mercer, Joshua Caddy, Fay Chinnery, Laura Day, Diana Fernando, Kirit Ardeshna, Graham Collins, John Radford, Simon Rule, Andrew Mcmillan, Peter Johnson and Gareth Griffiths
Type: Article
| 2022
Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial - I'ah Donovan-Banfield, Rebekah Penrice-Randal, Hannah Goldswain, Aleksandra M Rzeszutek, Jack Pilgrim, Katie Bullock, Geoffrey Saunders, Josh Northey, Xiaofeng Dong, Yan Ryan, Helen Reynolds, Michelle Tetlow, Lauren E Walker, Richard FitzGerald, Colin Hale, Rebecca Lyon, Christie Woods, Shazaad Ahmad, Dennis Hadjiyiannakis, Jimstan Periselneris, Emma Knox, Calley Middleton, Lara Lavelle-Langham, Victoria Shaw, William Greenhalf, Thomas Edwards, David G Lalloo, Christopher J Edwards, Alistair C Darby, Miles W Carroll, Gareth Griffiths, Saye H Khoo, Julian A Hiscox and Thomas Fletcher
Type: Article
| 2022
Body composition and chemotherapy toxicity in women with early breast cancer (CANDO-3): protocol for an observational cohort study - Kesta Durkin, Mohammad, Adam Heetun, Sean Ewings, Richard Munday, Stephen Wootton, Lesley Turner, Ellen Copson and Ramsey Cutress
Type: Article
| 2022
Planning a digital intervention for adolescents with asthma (BREATHE4T): a, theory-, evidence- and Person-Based Approach to identify key behavioural issues - Stephanie Easton, Ben Ainsworth, Mike Thomas, Sue Latter, Rebecca Knibb, Amber Cook, Sam Wilding, Michael Bahrami-Hessari, Erika J. Kennington, Denise Gibson, Hannah Wilkins, Lucy Yardley and Graham Roberts
Type: Article
| 2022
Parallel randomized controlled feasibility trials of the "Active Brains" digital intervention to protect cognitive health in adults aged 60-85 - Rosie Essery, Sebastien Pollet, Katherine Bradbury, Max J. J. Western, Elisabeth Grey, James Denison-Day, Kirsten A. Smith, Victoria Hayter, Joanne Kelly, Jane Somerville, Beth Stuart, Taeko Becque, Jin Zhang, Joanna Slodkowska-Barabasz, Fiona Mowbray, Anne Ferrey, Guiqing Yao, Shihua Zhu, Tony Kendrick, Simon Griffin, Nanette Mutrie, Sian Robinson, Helen Brooker, Gareth Griffiths, Louise Robinson, Martin Rossor, Clive Ballard, John Gallacher, Shanaya Rathod, Bernard Gudgin, Rosemary Phillips, Tom Stokes, John Niven, Paul Little and Lucy Yardley
Type: Article
| 2022
Practical recommendations for implementing a Bayesian adaptive phase I design during a pandemic - Sean Ewings, Geoffrey Saunders, Thomas Jaki and Pavel Mozgunov
Type: Article
| 2022
Pharmacokinetics of ß-d-N4-hydroxycytidine, the parent nucleoside of prodrug molnupiravir, in non-plasma compartments of patients with SARS-CoV-2 infection - Richard FitzGerald, Laura Dickinson, Laura Else, Thomas Fletcher, Colin Hale, Alieu Amara, Lauren Walker, Sujan Dilly Penchala, Rebecca Lyon, Victoria Shaw, William Greenhalf, Katie Bullock, Lara Lavelle-Langham, Helen Reynolds, Wendy Painter, Wayne Holman, Sean Ewings, Gareth Griffiths and Saye Khoo
Type: Article
| 2022
“Eczema shouldn’t control you; you should control eczema”: qualitative process evaluation of online behavioural interventions to support young people and parents/carers of children with eczema - Kate Greenwell, Katy Sivyer, Laura Howells, Mary Steele, Matthew J. Ridd, Amanda Roberts, Amina Ahmed, Sandra Lawton, Sinéad M. Langan, Julie Hooper, Sylvia Wilczynska, Paul Leighton, Gareth Griffiths, Tracey Sach, Paul Little, Hywel C. Williams, Kim S. Thomas, Lucy Yardley, Miriam Santer and Ingrid Muller
Type: Article
| 2022
| Item not available on this server.
CONFIRM trial: what is the real efficacy of second-line immunotherapy in mesothelioma? - Authors' reply - Gareth Griffiths
Type: Article
| 2022
| Item availability restricted.
Platinum-based chemotherapy ‘Rechallenge’ in advanced non-ovarian solid malignancies - Joanna Hack and Simon Crabb
Type: Article
| 2022
Does variation in swallowing organs-at-risk (SWOAR) delineation impact on predicted swallowing dysfunction for PATHOS trial patients? - Emma Higgins, Nachi Palaniappan and Zohal Nabi
Type: Article
| 2022
| Item not available on this server.
Co-living with migrant domestic workers is associated with a lower level of loneliness among community-dwelling older adults: a cross-sectional study - Ken Hok Man Ho, Daphne Sze Ki Cheung, Paul Hong Lee, Simon Ching Lam and Rick Yiu Cho Kwan
Type: Article
| 2022
| Item not available on this server.
Primary care service utilisation and outcomes in type 2 diabetes: a longitudinal cohort analysis - Sam Hodgson, Jeffrey Morgan-Harrisskit, Hilda Hounkpatin, Beth Stuart and Hajira Dambha-Miller
Type: Article
| 2022
Multiomics links global surfactant dysregulation with airflow obstruction and emphysema in COPD - Ventzislava A. Hristova, Alastair Watson, Raghothama Chaerkady, Matthew S. Glover, Jodie Ackland, Bastian Angermann, Graham Belfield, Maria Belvisi, Hannah Burke, Doriana Cellura, Howard W. Clark, Damla Etal, Anna Freeman, Ashley Heinson, S. Hess, Michael Hühn, Emily Hall, Alex Mackay, Jens Madsen, Christopher McCrae, Daniel Muthas, Steven Novick, Kristoffer Ostridge, Lisa Oberg, Adam Platt, Anthony Postle, Cosma Mirella Spalluto, Outi Vaarala, Junmin Wang, Karl J. Staples and Tom MA Wilkinson
Type: Article
| 2022
| Item availability restricted.
Treating Acute EXacerbations of COPD with Chinese HerbAL MedIcine to aid AntiBiotic Use Reduction (EXCALIBUR): study protocol of a randomised double-blind, placebo-controlled feasibility trial - Xiao-Yang Hu, Tom Oliver, Merlin Willcox, Catherine Simpson, Kerensa Thorne, Jeanne Trill, Nick Francis, Beth Stuart, Michael Thomas, Paul Little, Jian-Ping Liu, Gareth Griffiths and Michael Moore
Type: Article
| 2022
Combined HPV 16 E2 and L1 methylation predict response to treatment with cidofovir and imiquimod in patients with vulval intraepithelial neoplasia - Christopher Nicholas Hurt, Belinda Nedjai, Carlos Alvarez-Mendoza, Ned Powell, Amanda Tristram and Sadie Jones
Type: Article
| 2022
Blinding of study statisticians in clinical trials: a qualitative study in UK clinical trials units - Mais Iflaifel, Christopher Partlett, Jennifer Bell, Andrew Cook, Carrol Gamble, Steven Julious, Edmund Juszczak, Louise Linsell, Alan Montgomery and Kirsty Sprange
Type: Article
| 2022
| Item not available on this server.
Molnupiravir versus placebo in unvaccinated and vaccinated patients with early SARS-CoV-2 infection in the UK (AGILE CST-2): a randomised, placebo-controlled, double-blind, phase 2 trial - Saye H. Khoo, Richard FitzGerald and Geoffrey Saunders
Type: Article
| 2022
A randomised -controlled Phase 2 trial of molnupiravir in unvaccinated and vaccinated individuals with early SARS-CoV-2 - Saye H. Khoo, Richard FitzGerald and Geoffrey Saunders
Type: Article
| 2022
Whole-genome sequencing reveals host factors underlying critical COVID-19 - Athanasios Kousathanas, Erola Pairo-Castineira and Konrad Rawlik
Type: Article
| 2022
Sarcopenia and its association with objectively measured life-space mobility and moderate-to-vigorous physical activity in the oldest-old amid the COVID-19 pandemic when a physical distancing policy is in force - Rick Yiu Cho Kwan, Justina Yat Wa Liu, Yue Heng Yin, Paul Hong Lee, Siu Ying Ng, Daphne Sze Ki Cheung, Patrick Pui Kin Kor, Simon Ching Lam, Shirley Ka Lai Lo, Lin Yang, Siu Kay Chan and Vico Chung Lim Chiang
Type: Article
| 2022
Myopia control effect of defocus incorporated multiple segments (DIMS) spectacle lens in Chinese children: results of a 3-year follow-up study - Carly S.Y. Lam, Wing Chun Tang, Paul H. Lee, Han Yu Zhang, Hua Qi, Keigo Hasegawa and Chi Ho To
Type: Article
| 2022
| Item not available on this server.
Bedtime smart device usage and accelerometer-measured sleep outcomes in children and adolescents - Paul H. Lee, Andy C.Y. Tse, Teris Cheung, C. W. Do, Grace P.Y. Szeto, Billy C.L. So and Regina L.T. Lee
Type: Article
| 2022
Five-step hand hygiene programme for students with mild intellectual disability: abridged secondary publication - R.L.T. Lee, C. Leung, H. Chen, W. K. Tong and P. H. Lee
Type: Article
| 2022
| Item not available on this server.
Immune responses to SARS-CoV-2 variants after two and three doses of vaccine in B-cell malignancies: UK PROSECO Study - Sean H. Lim, Beth Stuart, Debora Joseph-Pietras, Marina Johnson, Nicola Campbell, Adam Kelly, Danielle Jeffrey, Anna H Turaj, Kate Rolfvondenbaumen, Celine Galloway, Thomas Wynn, Adam R. Coleman, Benjamin Ward, Karen Long, Helen Coleman, Carina Mundy, Andrew T. Bates, Diana Ayres, Robert Lown, Janlyn Falconer, Oliver Brake, James Batchelor, Victoria Willimott, Anna Bowzyk Al-Naeeb, Lisa Robinson, Ann O'Callaghan, Graham P Collins, Tobias Menne, Saul N Faust, Christopher P Fox, Matthew Ahearne, Peter W M Johnson, Andrew J Davies and David Goldblatt
Type: Article
| 2022
Self-sampling to identify pathogens and inflammatory markers in patients with acute sore throat: feasibility study - Mark Lown, Elizabeth A. Miles and Helena L. Fisk
Type: Article
| 2022
A digital intervention for respiratory tract infections (Internet Dr): process evaluation to understand how to support self-care for minor ailments - Sascha Miller, Lucy Yardley, Peter W.F. Smith, Mark Weal, Alexander MC Milton, Beth Stuart, Paul Little and Leanne Morrison
Type: Article
| 2022
Antenatal couples' counselling in Uganda (ACCU): study protocol for a randomised controlled feasibility trial - Vincent Mubangizi, Nuala McGrath, Jerome Kahuma Kabakyenga, Ingrid Muller, Beth L. Stuart, James P. Raftery, Sylvia Natukunda, Joseph Ngonzi, Clare Goodhart and Merlin Luke Willcox
Type: Article
| 2022
Patient acceptability of home monitoring for neovascular age-related macular degeneration reactivation: A qualitative study - Sean R. O'Connor, Andrew Lotery, Charlene Treanor, Elizabeth Ward, Robin Wickens, Abby O'Connell, Lucy A. Culliford, Chris A. Rogers, Eleanor A. Gidman, Tunde Peto, Paul C. Knox, Benjamin J.L. Burton, Andrew J. Lotery, Sobha Sivaprasad, Barnaby C. Reeves, Ruth E. Hogg and Michael Anthony Donnellan
Type: Article
| 2022
The COVID-19 pandemic and ophthalmic care: A qualitative study of patients with neovascular Age-Related Macular Degeneration (nAMD) - Sean R. O'Connor, Charlene Treanor, Elizabeth Ward, Robin Wickens, Abby O'Connel, Lucy A. Culliford, Chris A Rogers, Elanor A. Gidman, Tunde Peto, Paul C. Knox, Benjamin J.L. Burton, Andrew Lotery, Sobha Sivaprasad, Barnaby C Reeves, Ruth E. Hogg and Michael Donnelly
Type: Article
| 2022
Active symptom control with or without oral vinorelbine in patients with relapsed malignant pleural mesothelioma (VIM): a randomised, phase 2 trial - Catharine Porter, Jason Lester, Sarah Danson, Paul Taylor, Michael Sheaff, Robin M. Rudd, Aarti Gaba, Sara Busacca, Lisette Nixon, Georgina Gardner, Liz Darlison, Charlotte Poile, Cathy Richards, Peter-Wells Jordan, Gareth Griffiths and Angela Casbard
Type: Article
| 2022
The association between iron deficiency and outcomes: a secondary analysis of the intravenous iron therapy to treat iron deficiency anaemia in patients undergoing major abdominal surgery (PREVENTT) trial - T. Richards, L.F. Miles, B. Clevenger, A. Keegan, S. Abeysiri, R. Rao Baikady, M.W. Besser, J.P. Browne, Andrew Klein, I.C. Macdougall, G.J. Murphy, S.D. Anker and Darren Dahly
Type: Article
| 2022
Eczema Care Online behavioural interventions to support self-care for children and young people: two independent, pragmatic, randomised controlled trials - Miriam Santer, Ingrid Muller, Taeko Becque, Beth Stuart, Julie Hooper, Mary Steele, Sylvia Wilczynska, Tracey H Sach, Matthew J. Ridd, Amanda Roberts, Amina Ahmed, Lucy Yardley, Paul Little, Kate Greenwell, Katy Sivyer, Jacqueline Nuttall, Gareth Griffiths, Sandra Lawton, Sinéad Langan, Laura M Howells, Paul Leighton, Hywel Williams and Kim S. Thomas
Type: Article
| 2022
| Item not available on this server.
Type: Article
| 2022
Endovascular stent grafting and open surgical replacement for chronic thoracic aortic aneurysms: a systematic review and prospective cohort study - Linda Sharples, Priya Sastry, Carol Freeman, Joanne Gray, Andrew McCarthy, Yi-Da Chiu, Colin Bicknell, P. McMeekin, Srinivasa Rao Vallabhaneni, Andrew Cook, Luke Vale and Stephen Large
Type: Article
| 2022
ELEVATE - evaluating Temozolomide and Nivolumab in patients with advanced unresectable previously treated oesophagogastric adenocarcinoma with MGMT methylation: study protocol for a single arm phase II trial - Elizabeth Smyth, Kelly Cozens, Daniel Griffiths, Kathryn L Clark, Sean Ewings, Russell Petty, Tim Underwood, Rebecca C Fitzgerald, James Tanner, Olivier Giger, Shubha Anand and Gareth Griffiths
Type: Article
| 2022
Managing Parkinson’s during the COVID‐19 pandemic: perspectives from people living with Parkinson’s and health professionals - Dia Soilemezi, Helen C. Roberts, Maria Victoria Navarta‐sánchez, Dorit Kunkel, Sean Ewings, Claire Reidy and Mari Carmen Portillo
Type: Article
| 2022
Prediction of problem gambling by demographics, gaming behavior and psychological correlates among gacha gamers: A cross-sectional online survey in Chinese young adults - Anson Chui Yan Tang, Paul Hong Lee, Simon Ching Lam, Summer Cho Ngan Siu, Carmen Jiawen Ye and Regina Lai-Tong Lee
Type: Article
| 2022
Effects of exercise on sleep, melatonin level, and behavioral functioning in children with autism - Andy C.Y. Tse, Paul H. Lee, Jihui Zhang, Roy C.Y. Chan, Amy W.Y. Ho and Elvis W.H. Lai
Type: Article
| 2022
Study protocol for a randomized controlled trial comparing the effectiveness of physical exercise and melatonin supplement on treating sleep disturbance in children with autism spectrum disorders - Andy Choi Yeung Tse, Paul Hong Lee, Esther Yuet Ying Lau, James Ching Hei Cheng, Amy Wing Yin Ho and Elvis Wing Him Lai
Type: Article
| 2022
| Item not available on this server.
A dyadic pain management program for community-dwelling older adults with chronic pain: study protocol for a cluster randomized controlled trial - Mimi M. Y. Tse, Shamay S. M. Ng, Vivian Lou, Raymond Lo, Daphne Sze Ki Cheung, Paul Lee and Angel S. K. Tang
Type: Article
| 2022
Physical restraint events in psychiatric hospitals in Hong Kong: a cohort register study - Maritta Välimäki, Yuen Ting Joyce Lam, Kirsi Hipp and Paul Lee
Type: Article
| 2022
| Item not available on this server.
Digital interventions for hypertension and asthma to support patient self-management in primary care: the DIPSS research programme including two RCTs - Lucy Yardley, Kate Morton, Kate Greenwell, Beth Stuart, Cathy Rice, Katherine Bradbury, Ben Ainsworth, Rebecca Band, Elizabeth Murray, Frances Mair, Carl May, Susan Michie, Samantha Richards-Hall, Peter W.F. Smith, Anne Bruton, James Raftery, Shihua Zhu, Mike Thomas, Richard J. McManus and Paul Little
Type: Article
| 2022
Myopia control effect Is influenced by baseline relative peripheral refraction in children wearing Defocus Incorporated Multiple Segments (DIMS) Spectacle Lenses - Hanyu Zhang, Carly S.Y. Lam, Wing Chun Tang, Myra Leung, Hua Qi, Paul H. Lee and Chi Ho To
Type: Article
| 2022
Psychometric properties of the Mindsets of Depression, Anxiety, and Stress Scale (MDASS) in Chinese young adults and adolescents - Shimin Zhu, Yanqiong Zhuang and Paul Lee
Type: Article
| 2022
| Item not available on this server.
Monograph
Improving access to medicines to support palliative care at home: challenges and opportunities - Sue Latter, Natasha Campling, Jacqueline Birtwistle, Alison Richardson, Michael I Bennett, David Meads, Alison Blenkinsopp, Liz Breen, Zoe Edwards, Claire Sloan, Elizabeth Miller, Sean Ewings, Miriam Santer and Lesley Roberts
Type: Monograph
| 2022
| University of Southampton
Dataset
Type: Dataset
| 2022
| figshare
| Item not available on this server.
Editorial
Editorial: Adverse health consequences of excessive smartphone usage, volume II - Uichin Lee and Paul H. Lee
Type: Editorial
| 2022
| Item not available on this server.
Meeting abstract
Results of two online randomized controlled trials of the eczema care online intervention for parents/carers of children and young people with eczema - Kim S. Thomas, Miriam Santer, Ingrid Muller, Taeko Becque, Beth Stuart, Julie Hooper, Tracey H. Sach, Matthew J. Ridd, Amanda Roberts, Amina Ahmed, Mary Steele, Kate Greenwell, Katy Sivyer, Sylvia Wilczynska, Hywel C. Williams, Joanne R. Chalmers, Paul Leighton, Laura M. Howells, Sandra Lawton, Gareth Griffiths, Jacqui Nuttall, Hayden Kirk, Sinead M. Langan, Lucy Yardley and Paul Little
Type: Meeting abstract
| 2022
| Item not available on this server.